3 research outputs found
Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease
The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological
components, including oxidative stress, acetylcholinesterase, amyloid-b, and metal ions, all playing
a role. Here we report a strategic approach to designing flavonoids that can effectively tackle multiple
pathological elements involved in AD. Our systematic investigations revealed key structural features for
flavonoids to simultaneously target and regulate pathogenic targets. Our findings led to the development
of a highly promising flavonoid that exhibits a range of functions, based on a complete structure–activity
relationship analysis. Furthermore, our mechanistic studies confirmed that this flavonoid's versatile
reactivities are driven by its redox potential and direct interactions with pathogenic factors. This work
highlights the potential of multi-target-directed flavonoids as a novel solution in the fight against AD