Foreign-currency bonds: currency choice and the role of uncovered and covered interest parity

Using count-data techniques, this paper studies the determinants of currency choice in the issuance of foreign-currency-denominated bonds. In particular, we investigate whether bond issuers choose their issuance currency in order to exploit the borrowing-cost savings associated with deviations from uncovered and covered interest parity. Our sample includes issuers from both the public sector and private sector. Our findings show that the choice of issuance currency is sensitive to deviations from uncovered interest parity but insensitive, in general, to deviations from covered interest parity. Furthermore, the influence of deviations from uncovered interest parity is stronger for financial issuers than for nonfinancial issuers. JEL Classification: F31, F36, G14, G15, G32bonds, currency choice, foreign exchange, interest-rate parity, international debt securities

Three essays on exchange-rate misalignment

Theories of exchange-rate determination have generated a vast theoretical and empirical literature. This thesis adds to that body of literature by asking three questions. (i) How do policymakers respond to exchange-rate misalignment? (ii) How does misalignment affect the decisions of financial-market participants? (iii) What do exchange-rate dynamics reveal about the choices of investors in the face of currency risk? These three questions are tackled with studies that offer broad and tractable conclusions and contribute to furthering the current field of research

Review of \u3ci\u3ePrairie Republic: The Political Culture of Dakota Territory, 1879-1889\u3c/i\u3e by Jon K. Lauck

The Dakotas are often an overlooked and underexamined part of the United States. No one seems to know whether the region is part of the Midwest or the Real West, and so it often falls between the historiographical cracks. In this excellent study, Jon Lauck examines the political culture of the eastern region of South Dakota in the last decade before statehood. This period has been neglected by recent scholars, in part because it was often assumed that the standard work, Howard Lamar\u27s Dakota Territory, 1861-1889: A Study of Frontier Politics, published in 1956, had said the last word on the subject. But Lauck, while recognizing the strengths and contributions of Lamar\u27s study, also notes that, like all history, it was influenced by the preconceptions and the reigning historical orthodoxy of the era in which it was written and thus may merit reexamination more than a half-century later

Combating Childhood Obesity Through Nurse Practitioner-Led School Wellness Program

Overweight children and childhood obesity have been identified as an area of national and global concern. The prevalence of childhood obesity has been described as one of the most common chronic childhood conditions (Faguy, 2016). During the past decade, childhood obesity has been on the rise throughout the nation with an estimated childhood rate of 42 million to 70 million by 2025 (World Health Organization [WHO], 2014). The purpose of this prospective, quantitative study was to develop and implement a family nurse practitioner-led wellness intervention program in the school setting that incorporated nutrition and physical activity for adolescents. The review of literature revealed a lack of evidence regarding effectiveness of FNP-led wellness initiative in the school setting. Specific aims were to evaluate the pre- and post-intervention activity level and self-efficacy for diet and exercise of adolescents ages 14 to 17 during a 4-week FNP led school-based initiatives. Activity level was assessed through the use of Jawbone UP Move and Patient-Centered Assessment & Counseling for Exercise (PACE+) surveys. Participants experienced a significant improvement in their perspectives related to limiting the consumption of dietary when comparing baseline data to 4 weeks. Participants showed an increase in physical activity through the Jawbone UP Move from baseline to the end of the program. Participants demonstrated a reduction in diastolic blood pressure from baseline to completion of study. This translational childhood obesity school based project will contribute to the body of knowledge regarding FNPs and their role in reducing the prevalence and incidence of childhood obesity

Foreign-currency bonds: currency choice and the role of uncovered and covered interest parity

Using count-data techniques, this paper studies the determinants of currency choice in the issuance of foreign-currency-denominated bonds. In particular, we investigate whether bond issuers choose their issuance currency in order to exploit the borrowing-cost savings associated with deviations from uncovered and covered interest parity. Our sample includes issuers from both the public sector and private sector. Our findings show that the choice of issuance currency is sensitive to deviations from uncovered interest parity but insensitive, in general, to deviations from covered interest parity. Furthermore, the influence of deviations from uncovered interest parity is stronger for financial issuers than for nonfinancial issuers

Scoliosis treatment using spinal manipulation and the Pettibon Weighting System™: a summary of 3 atypical presentations

BACKGROUND: Given the relative lack of treatment options for mild to moderate scoliosis, when the Cobb angle measurements fall below the 25–30° range, conservative manual therapies for scoliosis treatment have been increasingly investigated in recent years. In this case series, we present 3 specific cases of scoliosis. CASE PRESENTATION: Patient presentation, examination, intervention and outcomes are detailed for each case. The types of scoliosis presented here are left thoracic, idiopathic scoliosis after Harrington rod instrumentation, and a left thoracic scoliosis secondary to Scheuermann's Kyphosis. Each case carries its own clinical significance, in relation to clinical presentation. The first patient presented for chiropractic treatment with a 35° thoracic dextroscoliosis 18 years following Harrington Rod instrumentation and fusion. The second patient presented with a 22° thoracic levoscoliosis and concomitant Scheuermann's Disease. Finally, the third case summarizes the treatment of a patient with a primary 37° idiopathic thoracic levoscoliosis. Each patient was treated with a novel active rehabilitation program for varying lengths of time, including spinal manipulation and a patented external head and body weighting system. Following a course of treatment, consisting of clinic and home care treatments, post-treatment radiographs and examinations were conducted. Improvement in symptoms and daily function was obtained in all 3 cases. Concerning Cobb angle measurements, there was an apparent reduction in Cobb angle of 13°, 8°, and 16° over a maximum of 12 weeks of treatment. CONCLUSION: Although mild to moderate reductions in Cobb angle measurements were achieved in these cases, these improvements may not be related to the symptomatic and functional improvements. The lack of a control also includes the possibility of a placebo effect. However, this study adds to the growing body of literature investigating methods by which mild to moderate cases of scoliosis can be treated conservatively. Further investigation is necessary to determine whether curve reduction and/or manipulation and/or placebo was responsible for the symptomatic and functional improvements noted in these cases

A novel method of non-clinical dispatch is associated with a higher rate of critical Helicopter Emergency Medical Service intervention

Background - Helicopter Emergency Medical Services (HEMS) are a scarce resource that can provide advanced emergency medical care to unwell or injured patients. Accurate tasking of HEMS is required to incidents where advanced pre-hospital clinical care is needed. We sought to evaluate any association between non-clinically trained dispatchers, following a bespoke algorithm, compared with HEMS paramedic dispatchers with respect to incidents requiring a critical HEMS intervention. Methods - Retrospective analysis of prospectively collected data from two 12-month periods was performed (Period one: 1st April 2014 – 1st April 2015; Period two: 1st April 2016 – 1st April 2017). Period 1 was a Paramedic-led dispatch process. Period 2 was a non-clinical HEMS dispatcher assisted by a bespoke algorithm. Kent, Surrey & Sussex HEMS (KSS HEMS) is tasked to approximately 2500 cases annually and operates 24/7 across south-east England. The primary outcome measure was incidence of a HEMS intervention.Results - A total of 4703 incidents were included; 2510 in period one and 2184 in period two. Variation in tasking was reduced by introducing non-clinical dispatchers. There was no difference in median time from 999 call to HEMS activation between period one and two (period one; median 7 min (IQR 4–17) vs period two; median 7 min (IQR 4–18). Non-clinical dispatch improved accuracy of HEMS tasking to a mission where a critical care intervention was required (OR 1.25, 95% CI 1.04–1.51, p = 0.02).Conclusion - The introduction of non-clinical, HEMS-specific dispatch, aided by a bespoke algorithm improved accuracy of HEMS tasking. Further research is warranted to explore where this model could be effective in other HEMS services.Peer reviewedFinal Published versio

A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment

OBJECTIVE: The objective of this study was to examine clinicians\u27 patient selection and result interpretation of a clinically validated mass spectrometry test measuring amyloid beta and ApoE blood biomarkers combined with patient age (PrecivityAD® blood test) in symptomatic patients evaluated for Alzheimer\u27s disease (AD) or other causes of cognitive decline. METHODS: The Quality Improvement and Clinical Utility PrecivityAD Clinician Survey (QUIP I, ClinicalTrials.gov Identifier: NCT05477056) was a prospective, single-arm cohort study among 366 patients evaluated by neurologists and other cognitive specialists. Participants underwent blood biomarker testing and received an amyloid probability score (APS), indicating the likelihood of a positive result on an amyloid positron emission tomography (PET) scan. The primary study outcomes were appropriateness of patient selection as well as result interpretation associated with PrecivityAD blood testing. RESULTS: A 95% (347/366) concordance rate was noted between clinicians\u27 patient selection and the test\u27s intended use criteria. In the final analysis including these 347 patients (median age 75 years, 56% women), prespecified test result categories incorporated 133 (38%) low APS, 162 (47%) high APS, and 52 (15%) intermediate APS patients. Clinicians\u27 pretest and posttest AD diagnosis probability changed from 58% to 23% in low APS patients and 71% to 89% in high APS patients (p \u3c 0.0001). Anti-AD drug therapy decreased by 46% in low APS patients (p \u3c 0.0001) and increased by 57% in high APS patients (p \u3c 0.0001). INTERPRETATION: These findings demonstrate the clinical utility of the PrecivityAD blood test in clinical care and may have added relevance as new AD therapies are introduced

The Role of Trust in Social Entrepreneurship: A Case Study of Global Brigades

This article aims to begin filling this gap by utilizing a specific social entrepreneurship initiative to illustrate the role of trust in social entrepreneurship efforts