2^2H (3^3He,t) 2p reaction at 2 GeV

E

Universal DNA methylation age across mammalian tissues

DATA AVAILABILITY STATEMENT : The individual-level data from the Mammalian Methylation Consortium can be accessed from several online locations. All data from the Mammalian Methylation Consortium are posted on Gene Expression Omnibus (complete dataset, GSE223748). Subsets of the datasets can also be downloaded from accession numbers GSE174758, GSE184211, GSE184213, GSE184215, GSE184216, GSE184218, GSE184220, GSE184221, GSE184224, GSE190660, GSE190661, GSE190662, GSE190663, GSE190664, GSE174544, GSE190665, GSE174767, GSE184222, GSE184223, GSE174777, GSE174778, GSE173330, GSE164127, GSE147002, GSE147003, GSE147004, GSE223943 and GSE223944. Additional details can be found in Supplementary Note 2. The mammalian data can also be downloaded from the Clock Foundation webpage: https://clockfoundation.org/MammalianMethylationConsortium. The mammalian methylation array is available through the non-profit Epigenetic Clock Development Foundation (https://clockfoundation.org/). The manifest file of the mammalian array and genome annotations of CpG sites can be found on Zenodo (10.5281/zenodo.7574747). All other data supporting the findings of this study are available from the corresponding author upon reasonable request. The chip manifest files, genome annotations of CpG sites and the software code for universal pan-mammalian clocks can be found on GitHub95 at https://github.com/shorvath/MammalianMethylationConsortium/tree/v2.0.0. The individual R code for the universal pan-mammalian clocks, EWAS analysis and functional enrichment studies can be also found in the Supplementary Code.SUPPLEMENTARY MATERIAL 1 : Supplementary Tables 1–3 and Notes 1–6.SUPPLEMENTARY MATERIAL 2 : Reporting SummarySUPPLEMENTARY MATERIAL 3 : Supplementary Data 1–14.SUPPLEMENTARY MATERIAL 4 : Supplementary Code.Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.https://www.nature.com/nataginghj2024Zoology and EntomologySDG-15:Life on lan

LA RÉACTION 16O(π+, p)15O A 70 MeV

Des premiers résultats ont été obtenus dans l'étude de la réaction 16O(π+, p)15O. Les niveaux trous (p 3/2)-1 et (p ½)-1 de 15O sont peuplés dans un rapport supérieur ou égal à 10. On observe un pic dans la région du premier niveau T = 3/2 de 15O. Ceci paraît en faveur d'un mécanisme de réaction mettant en jeu au moins deux nucléons du noyau-cible.First results have been obtained for the reaction 16O(π+, p)15O at 70 MeV. The hole-states (p 3/2)-1 and (p ½)-1 of 15O are excited with a ratio larger or equal to 10. A peak is observed which might be the first T = 3/2 level of 15O. This favours a two nucleon reaction mechanism

DIFFUSION QUASI LIBRE (p, pα) SUR LES NOYAUX PAIR-PAIR 24Mg, 28Si, 40Ca ET 58Ni

Une étude de la diffusion quasi libre (p, pα) a été faite, à 157 MeV, sur les noyaux pair-pair 24Mg, 28Si, 40Ca et 58Ni. Les facteurs spectroscopiques α pour les états fondamentaux 0+ des noyaux de recul 20Ne et 36A ont pu être extraits à partir des distributions d3σ/dEp dΩp dΩα en fonction de leur quantité de mouvement.Quasi-free (p, pα) scattering has been studied, at 157 MeV, on the even-even nuclei 24Mg, 28Si, 40Ca and 58Ni. α-spectroscopic factors have been extracted for the 0+ ground states of the 20Ne and 36A recoil nuclei, from the d3σ/dEp dΩp dΩα distributions as functions of the recoil momentum