A VELOUR post hoc subset analysis: prognostic groups and treatment outcomes in patients with metastatic colorectal cancer treated with aflibercept and FOLFIRI

The VELOUR study demonstrated a survival benefit for FOLFIRI + aflibercept versus FOLFIRI + placebo in metastatic colorectal cancer (mCRC) patients who progressed on oxaliplatin-based chemotherapy. Continued divergence of overall survival (OS) curves in the intension to treat (ITT) population, with the survival advantage persisting beyond median survival time, suggested subpopulations might have different magnitudes of survival gain. Additionally, 10% of patients within VELOUR had recurrence during or within 6 months of completing oxaliplatin-based adjuvant therapy (adjuvant fast relapsers) - previously identified as having poorer survival outcomes

SWAS and Arecibo observations of H2O and OH in a diffuse cloud along the line-of-sight to W51

Observations of W51 with the Submillimeter Wave Astronomy Satellite (SWAS) have yielded the first detection of water vapor in a diffuse molecular cloud. The water vapor lies in a foreground cloud that gives rise to an absorption feature at an LSR velocity of 6 km/s. The inferred H2O column density is 2.5E+13 cm-2. Observations with the Arecibo radio telescope of hydroxyl molecules at ten positions in W51 imply an OH column density of 8E+13 cm-2 in the same diffuse cloud. The observed H2O/OH ratio of ~ 0.3 is significantly larger than an upper limit derived previously from ultraviolet observations of the similar diffuse molecular cloud lying in front of HD 154368. The observed variation in H2O/OH likely points to the presence in one or both of these clouds of a warm (T > 400) gas component in which neutral-neutral reactions are important sources of OH and/or H2O.Comment: 15 pages (AASTeX) including 4 (eps) figures. To appear in the Astrophysical Journa

Modeling semi-conductor thermal properties. The dispersion role

We study heat transport in semiconductor nanostructures by solving the Boltzmann Transport Equation (BTE) by means of the Discrete Ordinate Method (DOM). Relaxation time and phase and group velocitiy spectral dependencies are taken into account. The Holland model of phonon relaxation time is revisited and recalculated from dispersion relations (taken in litterature) in order to match bulk silicon and germanium values. This improved model is then used to predict silicon nanowire and nanofilm thermal properties in both ballistic and mesoscopic regimes

Detection of interstellar CH_3

Observations with the Short Wavelength Spectrometer (SWS) onboard the {\it Infrared Space Observatory} (ISO) have led to the first detection of the methyl radical ${\rm CH_3}$ in the interstellar medium. The $\nu_2$ $Q-$branch at 16.5 $\mu$m and the $R$(0) line at 16.0 $\mu$m have been unambiguously detected toward the Galactic center SgrA$^*$. The analysis of the measured bands gives a column density of (8.0$\pm$2.4)$\times10^{14}$ cm$^{-2}$ and an excitation temperature of $(17\pm 2)$ K. Gaseous ${\rm CO}$ at a similarly low excitation temperature and ${\rm C_2H_2}$ are detected for the same line of sight. Using constraints on the ${\rm H_2}$ column density obtained from ${\rm C^{18}O}$ and visual extinction, the inferred ${\rm CH_3}$ abundance is $(1.3{{+2.2}\atop{-0.7}}) \times 10^{-8}$. The chemically related ${\rm CH_4}$ molecule is not detected, but the pure rotational lines of ${\rm CH}$ are seen with the Long Wavelength Spectrometer (LWS). The absolute abundances and the ${\rm CH_3/CH_4}$ and ${\rm CH_3/CH}$ ratios are inconsistent with published pure gas-phase models of dense clouds. The data require a mix of diffuse and translucent clouds with different densities and extinctions, and/or the development of translucent models in which gas-grain chemistry, freeze-out and reactions of ${\rm H}$ with polycyclic aromatic hydrocarbons and solid aliphatic material are included.Comment: 2 figures. ApJL, Accepte

Electromagnetic field correlations near a surface with a nonlocal optical response

The coherence length of the thermal electromagnetic field near a planar surface has a minimum value related to the nonlocal dielectric response of the material. We perform two model calculations of the electric energy density and the field's degree of spatial coherence. Above a polar crystal, the lattice constant gives the minimum coherence length. It also gives the upper limit to the near field energy density, cutting off its $1/z^3$ divergence. Near an electron plasma described by the semiclassical Lindhard dielectric function, the corresponding length scale is fixed by plasma screening to the Thomas-Fermi length. The electron mean free path, however, sets a larger scale where significant deviations from the local description are visible.Comment: 15 pages, 7 figure files (.eps), \documentclass[global]{svjour}, accepted in special issue "Optics on the Nanoscale" (Applied Physics B, eds. V. Shalaev and F. Tr\"ager

Casimir force between designed materials: what is possible and what not

We establish strict upper limits for the Casimir interaction between multilayered structures of arbitrary dielectric or diamagnetic materials. We discuss the appearance of different power laws due to frequency-dependent material constants. Simple analytical expressions are in good agreement with numerical calculations based on Lifshitz theory. We discuss the improvements required for current (meta) materials to achieve a repulsive Casimir force.Comment: 9 pages, 4 figures, graphicx, v4: Europhysics Letters, in pres

On the use of fractional Brownian motion simulations to determine the 3D statistical properties of interstellar gas

Based on fractional Brownian motion (fBm) simulations of 3D gas density and velocity fields, we present a study of the statistical properties of spectro-imagery observations (channel maps, integrated emission, and line centroid velocity) in the case of an optically thin medium at various temperatures. The power spectral index gamma_W of the integrated emission is identified with that of the 3D density field (gamma_n) provided the medium's depth is at least of the order of the largest transverse scale in the image, and the power spectrum of the centroid velocity map is found to have the same index gamma_C as that of the velocity field (gamma_v). Further tests with non-fBm density and velocity fields show that this last result holds, and is not modified either by the effects of density-velocity correlations. A comparison is made with the theoretical predictions of Lazarian & Pogosyan (2000).Comment: 28 pages, 14 figures, accepted for publication in ApJ. For preprint with higher-resolution figures, see http://www.cita.utoronto.ca/~mamd/miville_fbm2003.pd