Schoenberg Today: the Views of some Contemporary Composers

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The Relationships between Fitness Assessments, Fitness Levels and Coronary Heart Disease Risk Markers in Police Officers

Given the physical nature of a position in law enforcement, the assessment of cardiovascular (CV) health as well as muscular strength and endurance is paramount to ensuring the safety of these personnel and the citizens they serve. The present study retrospectively examined correlations between several markers of CV and muscular fitness for 65 local police officers (8 female, average age 35.6 ± 9.0 yrs, height 70.5 ± 2.8 in, weight 91.8 ± 18.7 kg, VO2 33.0 ± 5.3 mL/kg/min) taken from their annual screening including a graded exercise test (GXT; Bruce protocol), pushups completed in 1 minute, situps completed in 1 minute, handgrip strength, body composition (through DEXA and circumference measures) and bloodwork. Maximal oxygen uptake (VO2max) was estimated using the Foster equation. Coronary heart disease risk (CHD risk) was calculated using the online NIH 10-year heart attack risk calculator, which uses age, gender, total cholesterol, HDL cholesterol, smoking status, and blood pressure status in its algorithm. Significance was determined using an alpha level of 0.05. Interestingly, there was no significant correlation between VO2max and CHD risk (p = 0.1851). Apart from risk markers included in the risk calculation, CHD risk was significantly correlated with waist-hip ratio (r = 0.24739), and LDL cholesterol (r = 0.39117). VO2max was significantly negatively correlated with fat mass (r = -0.51849), body fat percentage (%BF; r = -0.64297), total cholesterol (TC; r = -0.3371), and LDL cholesterol (r = -0.267). Positive correlations were found between VO2max and other measures of fitness such as pushups (r = 0.54274), situps (r = 0.3282), and handgrip strength (r = 0.32041). As for body composition measures, %BF was significantly positively correlated with TC (r = 0.30188), systolic blood pressure (r = 0.28795), LDL cholesterol (r = 0.26533), and fasting glucose (r = 0.26536), but negatively correlated with fitness markers such as pushups (r = -0.58599), situps (r = -0.43604), and handgrip strength (r = -0.32393). Lean mass was significantly correlated with handgrip strength (r = 0.71835), though not pushups, situps or VO2max. Waist circumference was significantly negatively correlated with HDL cholesterol (r = -0.39202). Additionally, 62 of the participants (7 female) completed both a 1.5 mile run and GXT, allowing for a comparison of a submaximal to a maximal fitness assessment of CV fitness. Time to complete 1.5 miles was significantly correlated to GXT VO2max, with a Pearson correlation coefficient of -0.79593. Overall, relationships found between health markers, fitness, and CHD risk in this sample were in line with previous research on CHD risk factors and the assessment of CV and muscular fitness

Determining the feasibility of harvesting invasive alien plant species for energy

Woody invasive alien plants (IAPs) are a threat to South Africa’s water resources, biodiversity and land productivity. The impacts of IAPs were the main reason for the South African government to embark on a natural resource management public works programme called Working for Water (WfW), which was aimed at controlling IAPs in a cost-effective yet labour-intensive way. At the same time, the high biomass of these species presents opportunities for synergies between the clearing of IAPs and the generation of biomassbased energy. The purpose of this study was to determine the cost of harvesting and extracting, chipping, and transporting the biomass, and also to determine the financial and economic feasibility of such an exercise from a commercial perspective. Sampling of the biomass was done at 31 representative sites within the Nelson Mandela Metropolitan Municipality, South Africa. The cost of the operation was carefully monitored, documented and reported at each stage, and compared to the cost of replacing the thermal coal currently used by industry within this municipality. The project proved to be financially viable, but only when the energy entrepreneur forms a partnership with the WfW programme, and then only under specific conditions. The project has, however, very high socio-economic returns with respect to a reduction in environmental externalities and job creation.Working for Water and the Industrial Development Corporationhttp://www.sajs.co.zahb201

Determining the feasibility of harvesting invasive alien plant species for energy

Woody invasive alien plants (IAPs) are a threat to South Africa’s water resources, biodiversity and land productivity. The impacts of IAPs were the main reason for the South African government to embark on a natural resource management public works programme called Working for Water (WfW), which was aimed at controlling IAPs in a cost-effective yet labour-intensive way. At the same time, the high biomass of these species presents opportunities for synergies between the clearing of IAPs and the generation of biomassbased energy. The purpose of this study was to determine the cost of harvesting and extracting, chipping, and transporting the biomass, and also to determine the financial and economic feasibility of such an exercise from a commercial perspective. Sampling of the biomass was done at 31 representative sites within the Nelson Mandela Metropolitan Municipality, South Africa. The cost of the operation was carefully monitored, documented and reported at each stage, and compared to the cost of replacing the thermal coal currently used by industry within this municipality. The project proved to be financially viable, but only when the energy entrepreneur forms a partnership with the WfW programme, and then only under specific conditions. The project has, however, very high socio-economic returns with respect to a reduction in environmental externalities and job creation.Working for Water and the Industrial Development Corporationhttp://www.sajs.co.zahb201

A One Medicine Mission for an Effective Rabies Therapy

Despite the disease's long history, little progress has been made toward a treatment for rabies. The prognosis for patient recovery remains dire. For any prospect of survival, patients require aggressive critical care, which physicians in rabies endemic areas may be reluctant or unable to provide given the cost, clinical expertise required, and uncertain outcome. Systematic clinical research into combination therapies is further hampered by sporadic occurrence of cases. In this Perspective, we examine the case for a One Medicine approach to accelerate development of an effective therapy for rabies through the veterinary care and investigational treatment of naturally infected dogs in appropriate circumstances. We review the pathogenesis of rabies virus in humans and dogs, including recent advances in our understanding of the molecular basis for the severe neurological dysfunction. We propose that four categories of disease process need to be managed in patients: viral propagation, neuronal degeneration, inflammation and systemic compromise. Compassionate critical care and investigational treatment of naturally infected dogs receiving supportive therapy that mimics the human clinical scenario could increase opportunities to study combination therapies that address these processes, and to identify biomarkers for prognosis and therapeutic response. We discuss the safety and ethics of this approach, and introduce the Canine Rabies Treatment Initiative, a non-profit organization with the mission to apply a One Medicine approach to the investigation of diagnostic, prognostic, and therapeutic options for rabies in naturally infected dogs, to accelerate transformation of rabies into a treatable disease for all patients

Childhood trauma: methods for the identification of physeal fractures in non-adult skeletal remains

Objectives Today, fractures at the growth plate (or physis) are common injuries in children, but provide challenges of identification in skeletonized remains. Clinical studies provide detailed information on the mechanisms, locations, age of occurrence, and complications associated with physeal fractures, enabling the development of new criteria for identifying this injury in non-adults. To test these criteria, skeletal remains from five rural and urban medieval cemeteries were examined. Methods The sample consisted of 961 skeletons (0-17 years) with open epiphyses. Macroscopic observation looked for any irregularities of the metaphysis or epiphysis which was consistent with the clinical appearance of physeal fractures or resulting complications. Radiographic examination was applied to identify fracture lines or early growth arrest. Results This study revealed 12 cases of physeal trauma (1.2%). Physeal fractures occurred predominantly at the distal end (75%), and while they were identified in all age categories, they were most frequent in those aged 12-17 years (0.2% TPR). The humerus was the most commonly affected location (3/12 or 25%). Conclusions This study highlights the potential for recognizing physeal fractures in children of all ages, enhancing our understanding of non-adult trauma, and enabling us to assign a more precise age of the injury to build up a picture of their activities in the past

Cardiovascular health risk among university students in South Africa

Tradisioneel is individue se vermoëns, belangstellings en persoonlikhede tydens beroepsvoorligting en werwings- en keuringsprosesse geassesseer, terwyl slegs enkele studies op die liggaamlike gesondheid van tweedejaarstudente, as intreevlakwerknemers vir sakeondernemings in Suid- Afrika, gefokus het. Die hoofdoel van hierdie navorsing was om die stand van die kardiovaskulêre gesondheid van universiteitstudente in hul tweede jaar (as intreevlakwerknemers) te bepaal. Die motivering vir die studie was tweeledig: eerstens om die huidige kardiovaskulêre gesondheidsrisiko van studente te bepaal, en tweedens om hulle in te lig oor die mate van risiko waaraan hulle blootgestel is. Die studie was ’n kwantitatiewe deursneestudie wat onderneem is om inligting in te win oor die kardiovaskulêre gesondheid van universiteitstudente. Die steekproef wat vir hierdie navorsingstudie gebruik is, het bestaan uit 162 universiteitstudente in Suid-Afrika wat almal tussen 18 en 25 jaar oud was. Die resultate het aangedui dat 55.6% van die betrokke studente aan hoë bloeddruk gely het. Uit laasgenoemde groep studente is 81.1% as prehipertensief gediagnoseer, terwyl stadium 1-hipertensie by 18.9% gediagnoseer is. Altesaam 64.8% van al die deelnemende studente se tellings is in die hoër meetgebied van die Kardiale Stresindeks (KSI). Ongelukkig het 61% van dié studente met verhoogde KSI-tellings ook hoë bloeddruk getoon. Benewens verhoogde harttempo en bloeddruk het 15.2% van die deelnemers ook swak harttempoveranderlikheid getoon. Dus het byna 10% van die totale steekproef verhoogde kardiale stresvlakke, verhoogde harttempo en hoë bloeddrukvlakke vertoon. Die resultate dui daarop dat universiteitstudente heeltemal onbewus is van hul kardiovaskulêre gesondheid en van die moontlikheid dat dit ’n invloed op hul loopbane kan hê. Beroepsvoorligters, industriële sielkundiges, opvoedkundige sielkundiges en praktisyns op die gebied van menslikehulpbronbestuur kan hierdie inligting voordelig binne die bestek van hul praktyk gebruik om beroepsvoorligting aan fisiologiestudente te verskaf. Dié praktiese benadering sal fisiologiestudente ook in staat stel om vas te stel wat hul eie kardiovaskulêregesondheidsrisiko’s is.Traditionally, individuals’ abilities, interests and personality were assessed during career guidance and recruitment and selection processes; however, only a few studies focused on the actual health of second-year students, as entry-level employees for business in South Africa. The main research purpose was to determine the cardiovascular health of second-year university students’ (as young entry-level employees). The motivations for the study are two-fold: to determine the current cardiovascular health risk of students, and to educate the students about such risk. The study was a quantitative cross-sectional study to determine university students’ cardiovascular health. The sample used in this research study consisted of 162 university students in South Africa, between the ages of 18 and 25 years. The results indicated that 55.6% students had high blood pressure. Then 81.1% of the latter group of students were identified as prehypertensive, while 18.9% were considered as having stage-1 hypertension. Students exhibited elevated cardiac stress as well. Altogether 64.8% of all the participating students scored in the elevated range of the Cardiac Stress Index (CSI). Unfortunately, 61% of the students with elevated CSI readings also exhibited high blood pressure. Furthermore, of the latter group, 15.2% exhibited poor heart rate variability, as well as elevated heart rate and blood pressure. Therefore, nearly 10% of the total sample exhibited elevated cardiac stress, an elevated heart rate and high blood pressure levels. The implications of the results are that university students are unaware of their cardiovascular health and that it may have an effect on their careers. Career counsellors, industrial psychologists, educational psychologists, and human resource management practitioners may benefit from this information in their scope of practice to guide physiology students in their career. This practical approach also allows physiology students to determine their own cardiovascular health risks.http://www.satnt.ac.zaam201

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. METHODS: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis. RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P  =  5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P  =  2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively. CONCLUSIONS: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function

Lipid Profiles of American Collegiate Football Athletes in Response to Fall Preseason Camp

Recent studies show former football athletes, especially football linemen, to be at increased cardiovascular disease risk. However, the lipid profiles of American NCAA Football Bowl Subdivision (FBS) players in response to sport participation are currently unknown. PURPOSE: To quantify the effects of participation in fall preseason football training camp on the blood lipid profiles in NCAA FBS athletes. METHODS: Seated venous blood samples were drawn in the morning after an overnight fast from 51 football players (age = 20 ± 2 yr, weight = 232.8 ± 40.8 lb, height = 73.9 ± 2.6 in) and analyzed for total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HLD-C), and triglyceride (TG). Samples were obtained on two separate occasions corresponding to the beginning of fall preseason football camp, and again 16 days later near the end. Data were analyzed by paired t-test. RESULTS: See table, values are means ± SD, * = p ≤ 0.001. Measurement Time Lipid and Lipoprotein Concentrations (mg/dL) TC LDL-C HDL-C TG TC:HDL Ratio Beginning 158 ± 34 90 ± 24 54 ± 15 117 ± 50 3.02 ± 0.70 End 151 ± 35 92 ± 28 47 ± 11* 86 ± 41* 3.32 ± 0.84* CONCLUSION: Participation in fall preseason training camp significantly alters the traditional lipid profiles of Collegiate FBS athletes. These lipid changes suggest a proinflammatory state with high energy utilization, and are consistent with the hypothesis that LDL-C is necessary for the structural repair of damaged tissue