2 research outputs found
The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
A novel vesicle transport mechanism is described that requires dysbindin-associated complexes for cargo targeting from neuronal cell bodies to neurites and nerve terminals. The results suggest that mistargeting of specific vesicular cargoes may underlie, in part, the molecular pathogenesis of schizophrenia