Cryogenic electro-optic interconnect for superconducting devices

Encoding information onto optical fields is the backbone of modern telecommunication networks. Optical fibers offer low loss transport and vast bandwidth compared to electrical cables, and are currently also replacing coaxial cables for short-range communications. Optical fibers also exhibit significantly lower thermal conductivity, making optical interconnects attractive for interfacing with superconducting circuits and devices. Yet little is known about modulation at cryogenic temperatures. Here we demonstrate a proof-of-principle experiment, showing that currently employed Ti-doped LiNbO modulators maintain the Pockels coefficient at 3K---a base temperature for classical microwave amplifier circuitry. We realize electro-optical read-out of a superconducting electromechanical circuit to perform both coherent spectroscopy, measuring optomechanically-induced transparency, and incoherent thermometry, encoding the thermomechanical sidebands in an optical signal. Although the achieved noise figures are high, approaches that match the lower-bandwidth microwave signals, use integrated devices or materials with higher EO coefficient, should achieve added noise similar to current HEMT amplifiers, providing a route to parallel readout for emerging quantum or classical computing platforms.Comment: Experimental details added. The heating experiment update

Two-dimensional optomechanical crystal resonator in gallium arsenide

In the field of quantum computation and communication there is a compelling need for quantum-coherent frequency conversion between microwave electronics and infra-red optics. A promising platform for this is an optomechanical crystal resonator that uses simultaneous photonic and phononic crystals to create a co-localized cavity coupling an electromagnetic mode to an acoustic mode, which then via electromechanical interactions can undergo direct transduction to electronics. The majority of work in this area has been on one-dimensional nanobeam resonators which provide strong optomechanical couplings but, due to their geometry, suffer from an inability to dissipate heat produced by the laser pumping required for operation. Recently, a quasi-two-dimensional optomechanical crystal cavity was developed in silicon exhibiting similarly strong coupling with better thermalization, but at a mechanical frequency above optimal qubit operating frequencies. Here we adapt this design to gallium arsenide, a natural thin-film single-crystal piezoelectric that can incorporate electromechanical interactions, obtaining a mechanical resonant mode at f_m ~ 4.5 GHz ideal for superconducting qubits, and demonstrating optomechanical coupling g_om/(2pi) ~ 650 kHz

Bidirectional multi-photon communication between remote superconducting nodes

Quantum communication testbeds provide a useful resource for experimentally investigating a variety of communication protocols. Here we demonstrate a superconducting circuit testbed with bidirectional multi-photon state transfer capability using time-domain shaped wavepackets. The system we use to achieve this comprises two remote nodes, each including a tunable superconducting transmon qubit and a tunable microwave-frequency resonator, linked by a 2 m-long superconducting coplanar waveguide, which serves as a transmission line. We transfer both individual and superposition Fock states between the two remote nodes, and additionally show that this bidirectional state transfer can be done simultaneously, as well as used to entangle elements in the two nodes.Comment: Main Paper has 6 pages, 4 figures. Supplementary has 14 pages, 16 figures, 2 table

Developing a platform for linear mechanical quantum computing

Linear optical quantum computing provides a desirable approach to quantum computing, with a short list of required elements. The similarity between photons and phonons points to the interesting potential for linear mechanical quantum computing (LMQC), using phonons in place of photons. While single-phonon sources and detectors have been demonstrated, a phononic beamsplitter element remains an outstanding requirement. Here we demonstrate such an element, using two superconducting qubits to fully characterize a beamsplitter with single phonons. We further use the beamsplitter to demonstrate two-phonon interference, a requirement for two-qubit gates, completing the toolbox needed for LMQC. This advance brings linear quantum computing to a fully solid-state system, along with straightforward conversion between itinerant phonons and superconducting qubits

Modular Quantum Processor with an All-to-All Reconfigurable Router

Superconducting qubits provide a promising approach to large-scale fault-tolerant quantum computing. However, qubit connectivity on a planar surface is typically restricted to only a few neighboring qubits. Achieving longer-range and more flexible connectivity, which is particularly appealing in light of recent developments in error-correcting codes, however, usually involves complex multilayer packaging and external cabling, which is resource intensive and can impose fidelity limitations. Here, we propose and realize a high-speed on-chip quantum processor that supports reconfigurable all-to-all coupling with a large on-off ratio. We implement the design in a four-node quantum processor, built with a modular design comprising a wiring substrate coupled to two separate qubit-bearing substrates, each including two single-qubit nodes. We use this device to demonstrate reconfigurable controlled- gates across all qubit pairs, with a benchmarked average fidelity of 96.00% ± 0.08% and best fidelity of 97.14% ± 0.07%, limited mainly by dephasing in the qubits. We also generate multiqubit entanglement, distributed across the separate modules, demonstrating GHZ-3 and GHZ-4 states with fidelities of 88.15% ± 0.24% and 75.18% ± 0.11%, respectively. This approach promises efficient scaling to larger-scale quantum circuits and offers a pathway for implementing quantum algorithms and error-correction schemes that benefit from enhanced qubit connectivity

Knockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice

The enzyme 5-lipoxygenase (5LO) has been implicated in a variety of neurological and psychiatric disorders including anxiety. Knockout of 5LO has previously been shown to alter anxiety-like behavior in mice at a young age but the effect of 5LO knockout on older animals has not been characterized.Here we used the elevated plus maze behavioral paradigm to measure anxiety-like behavior in female mice lacking 5LO (5LO-KO) at three different ages. Adolescent 5LO-KO animals did not significantly differ from wild-type (WT) animals in anxiety-like behavior. However, adult and older mice exhibited increased anxiety-like behavior compared to WT controls.These results indicate that 5LO plays a role in the development of the anxiety-like phenotype in an age-dependent manner in female mice. Future work should further investigate this interaction as 5LO may prove to be an important molecular target for the development of novel anxiolytic therapies

Automated wide-ranged finely tunable microwave cavity for narrowband phase noise filtering

Narrowband microwave filters have wide ranging applications, including the reduction in phase noise of microwave sources within a given frequency band. The prospect of developing an automated filter that tunes itself to an arbitrary desired frequency at maximum extinction promises many experimental advantages such as an enhanced efficiency in performing fine frequency detuning scans and saving time and effort as compared to manual tuning. We design, construct, and program such an automated system and present its hardware and software for reproducibility. It consists of a cylindrical cavity filter and two motors, which change the cavity length and the coupling strength of the microwave field into the cavity, respectively. By measuring the cavity response, an algorithm implemented in Python optimizes these two parameters to achieve the tuning of the filter cavity to the desired frequency with a precision of around 20 kHz, which is significantly better than the cavity linewidth (similar to 1 MHz). We also demonstrate the suppression of phase noise at the desired frequency by more than 10 dB

Using Biomarkers to Predict Memantine Effects in Alzheimer's Disease: A Proposal and Proof-Of-Concept Demonstration.

Memantine's benefits in Alzheimer's disease (AD) are modest and heterogeneous. We tested the feasibility of using sensitivity to acute memantine challenge to predict an individual's clinical response. Eight participants completed a double-blind challenge study of memantine (placebo versus 20 mg) effects on autonomic, subjective, cognitive, and neurophysiological measures, followed by a 24-week unblinded active-dose therapeutic trial (10 mg bid). Study participation was well tolerated. Subgroups based on memantine sensitivity on specific laboratory measures differed in their clinical response to memantine, some by large effect sizes. It appears feasible to use biomarkers to predict clinical sensitivity to memantine

Rethinking schizophrenia in the context of normal neurodevelopment

The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to consider how pathological changes identified in adult brain tissue can be accounted for by aberrant developmental processes occurring during fetal, childhood, or adolescent periods. To place schizophrenia neuropathology in a neurodevelopmental context requires solid, scrutinized evidence of changes occurring during normal development of the human brain, particularly in the cortex; however, too often data on normative developmental change are selectively referenced. This paper focuses on the development of the prefrontal cortex and charts major molecular, cellular, and behavioral events on a similar time line. We first consider the time at which human cognitive abilities such as selective attention, working memory, and inhibitory control mature, emphasizing that attainment of full adult potential is a process requiring decades. We review the timing of neurogenesis, neuronal migration, white matter changes (myelination), and synapse development. We consider how molecular changes in neurotransmitter signaling pathways are altered throughout life and how they may be concomitant with cellular and cognitive changes. We end with a consideration of how the response to drugs of abuse changes with age. We conclude that the concepts around the timing of cortical neuronal migration, interneuron maturation, and synaptic regression in humans may need revision and include greater emphasis on the protracted and dynamic changes occurring in adolescence. Updating our current understanding of post-natal neurodevelopment should aid researchers in interpreting gray matter changes and derailed neurodevelopmental processes that could underlie emergence of psychosis