PREVALENCE OF METABOLIC SYNDROME IN YOUNG V/S OLD APPARENTLY HEALTHY ASIAN INDIAN GUJARATI POPULATION

Introduction: The metabolic syndrome (MetS) is an epidemiological construct of different permutations of risk factors. We aimed to compare and study the overall prevalence of MetS in healthy, asymptomatic young v/s old Gujarati population. Methods: This population based- cross sectional study involved a total of 3329 healthy adults of 18-70 years of age. Clinical data such as body mass index (BMI), waist circumference (WC), blood pressure (BP) were measured along with the biochemical estimations of lipids and fasting blood glucose (FBS). The overall population was categorized in young (<40 years) and old (≥40 years) individuals. Results: The overall prevalence of MetS was 34.3% where the incidence was found to be more than double in old(45.4%) as compared to young population (20.8%, p<0.0001). The level of FBS (99.82 ± 38.49 vs 87.65 ± 19.82), HDL-C (38.94 ± 7.35 vs 37 ± 6.42) and LDL-C (129.45 ± 33.88 vs 117.39 ± 30.38) were significantly (p<0.05) higher in older population as compared to younger population. In both the age groups the prevalence of MetS was higher in males as compared to females and was majorly contributed by increased FBS level. However in old (95.6% vs 84.2) and young (84% vs 96%) females, the abnormalities of WC were significantly higher than their male counterparts. Conclusion: In summary we conclude that MetS is prevalent in Gujarati population and is subjected to age and gender. This results reinforces the need of early life style intervention and awareness programs in this ethnic group

Predictive role of fragmented QRS in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Objective: Fragmented QRS (fQRS), as defined by additional spikes in the QRS complex of a 12-lead electrocardiogram (ECG), is a marker of scarred myocardium. In patients with coronary artery disease (CAD), fQRS is a predictor of heart failure (HF) and other major adverse cardiac events (MACE). The study was aimed to evaluate the role of fQRS in prediction of HF in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: In a prospective, non-randomized, small observational study, we enrolled 188 consecutive patients with STEMI undergoing primary PCI. Patients were grouped according to the presence or absence of fQRS and their in-hospital, 1 and 6-month MACE outcomes were assessed. Results: Of the 188 patients, fQRS were noted in 92 (48.94%) patients. Patients with fQRS were more likely to have Killip class II/III/IV. Patients with fQRS had a significantly higher corrected QT interval, lower left ventricular ejection fraction (LVEF), and higher N-terminal pro brain natriuretic peptide (NT-pro BNP) at 24 hours and 48 hours compared to patients without fQRS. The in-hospital (P=0.001), 30-day (P=0.03) and 6-month (p=0.01) MACE were higher in patients with fQRS. On logistic multiple analysis, fQRS in anterior leads (OR=3.70, CI=1.68-10.02, p=0.001), fQRS in more than 2 leads (OR=5.20, CI=1.51-12.83, p=0.01), NT-proBNP (OR=1.05, CI=1.03-1.08, p=0.02) and Killip class II/III/IV were found to be significant predictors for HF hospitalization. Conclusion: Our findings suggest that fQRS can be a predictor for HF in patients with STEMI and provide a simple and readily available technique for predicting prognosis. Larger studies are required to validate these findings

Synthesis of quinoline-pyrazoline based thiazole derivatives endowed with antimicrobial activity

1191-1201A new series of 2-(5-(2-chloroquinolin-3-yl)-3-(aryl)-4,5-dihydro-1<i style="mso-bidi-font-style: normal">H-pyrazol-1-yl)thiazol-4(5H)ones 4a-l have been prepared and characterized by IR, NMR and mass spectroscopy. The synthesized compounds have been screened for antimicrobial activity against microbial strains: Escherichia coli, Pseudomonas<span style="mso-bidi-font-style: italic"> aeruginosa, Staphylococcus<span style="mso-bidi-font-style: italic"> aureus, Streptococcus pyogenes<span style="mso-bidi-font-style: italic">, Candida albicans, <i style="mso-bidi-font-style: normal">Aspergillus niger and <i style="mso-bidi-font-style: normal">Aspergillus clavatus. Almost all the tested compounds are found to possess variable degrees of antimicrobial activity. Collectively, compounds 4e, <b style="mso-bidi-font-weight: normal">4g, 4h, 4i and <b style="mso-bidi-font-weight: normal">4l can be considered as possible agents with antimicrobial activity. </span

Diagnostic accuracy of computed tomography angiography as compared to conventional angiography in patients undergoing noncoronary cardiac surgery

Objective: To compare the diagnostic accuracy of multi-slice computed tomography (MSCT) angiography with conventional angiography in patients undergoing major noncoronary cardiac surgeries. Materials and Methods: We studied fifty major noncoronary cardiac surgery patients scheduled for invasive coronary angiography, 29 (58%) female and 21 (42%) male. Inclusion criteria of the study were age of the patients ≥40 years, having low or intermediate probability of coronary artery disease (CAD), left ventricular ejection fraction (LVEF) >35%, and patient giving informed consent for undergoing MSCT and conventional coronary angiography. The patients with LVEF <35%, high pretest probability of CAD, and hemodynamically unstable were excluded from the study. Results: The diagnostic accuracy of CT coronary angiography was evaluated regarding true positive, true negative values. The overall sensitivity and specificity of CT angiography technique was 100% (95% confidence interval [CI]: 39.76%–100%) and 91.30% (95% CI: 79.21%–97.58%). The positive (50%; 95% CI: 15.70%–84.30%) and negative predictive values (100%; 95% CI: 91.59%–100%) of CT angiography were also fairly high in these patients. Conclusion: Our study suggests that this non-invasive technique may improve perioperative risk stratification in patients undegoing non-cardiac surgery