10 research outputs found
Giant Osteofibrous Dysplasia (Ossifying Fibroma) of the Tibia: Case Report and Review of Treatment Modalities
We present a case of giant osteofibrous dysplasia (OFB) of the proximal tibia with 15 years of follow-up. The tumor recurred
after first biopsy and curettage done at the age of 6 years and, again, 4 years later. Following recurrence, the option of
amputation was suggested. Staged treatment of curettage, cryosurgery, bone cement as a temporary spacer with internal
fixation at age 12 years, followed by bone grafting at age 14 years, led to complete healing. The staged protocol for treatment
is proposed as an alternative to more radical solutions. It is suggested to postpone surgical treatment towards skeletal
maturity
Gemcitabine in Bone Sarcoma Resistant to Doxorubicin-Based Chemotherapy
Subjects and Methods: Seven patients with progressive localized or
metastatic chemo-resistant osteosarcoma were treated by gemcitabine.The protocol
included gemcitabine 1000 mg/m2/w for 7 consecutive weeks, followed by 1 week rest. If no
progression was observed,maintenance by gemcitabine 1000 mg/m2/w for 3 weeks every 28
days was given until failure was clinically or radiologically evident
Periosteal Ewing's Sarcoma: Report of Two New Cases and Review of the Literature
Background. The origin of Ewing's sarcoma in a periosteal location is
rare and not clearly documented. Other malignant bone tumors appear to have a
somewhat better prognosis when confined between periosteum and bone. Is it the
same for periosteal Ewing's sarcoma
Novel Genes Implicated in Embryonal, Alveolar, and Pleomorphic Rhabdomyosarcoma: A Cytogenetic and Molecular Analysis of Primary Tumors
Rhabdomyosarcoma, the most common pediatric soft tissue sarcoma, likely results from deregulation of the skeletal myogenesis program. Although associations between PAX3, PAX7, FOXO1A, and RMS tumorigenesis are well recognized, the entire spectrum of genetic factors underlying RMS development and progression is unclear. Using a combined approach of spectral karyotyping, array-based comparative genomic hybridization (CGH), and expression analysis, we examined 10 primary RMS tumors, including embryonal, alveolar, and the rare adult pleomorphic variant, to explore the involvement of different genes and genetic pathways in RMS tumorigenesis. A complete karyotype established for each tumor revealed a high aneuploidy level, mostly tetraploidy, with double minutes and additional structural aberrations. Quantitative expression analysis detected the overexpression of the AURKA gene in all tumors tested, suggesting a role for this mitotic regulator in the aneuploidy and chromosomal instability observed in RMS. Array-based CGH analysis in primary RMS tumors detected copy number changes of genes involved in multiple genetic pathways, including transcription factors such as MYC-related gene from lung cancer and the cytoskeleton and cell adhesion-encoding genes laminin Îł-2 and p21-activated kinase-1. Our data suggest the involvement of genes encoding cell adhesion, cytoskeletal signaling, and transcriptional and cell cycle components in RMS tumorigenesis
Immunohistochemistry Evaluation of the Effect in Vivo of Tumor Necrosis Factor (TNF)-α on Blood Vessel Density in Murine Fibrosarcoma
Purpose: Angiogenesis is essential for tumor growth and metastases, thus bestowing obvious importance upon methodologies
which could enable its inhibition