College Students as Mentors for At-Risk Youth: A Study of Six Campus Partners in Learning Programs

In this study of the effects of college-student mentoring on elementary, junior-high and high-school students, P/PV examined six Campus Partners in Learning (CPIL) programs that implemented a common programmatic core in different ways, such as by varying the size of classes, the age of students served and the location of the mentoring sessions. The report concludes such mentoring can be an effective tool in improving academic and social outcomes but cautions that involving college students as mentors presents special challenges that require administrative structure and substantive support beyond that typically provided

Making a Difference: An Impact Study of Big Brothers/Big Sisters (Re-issue of 1995 Study)

This is a reissue of P/PV's 1995 impact study of Big Brothers Big Sisters, Making a Difference, which proved that BBBS' high-quality mentoring has tangible and significant effects on the lives of youth. Researchers examined the lives of 1,000 10- to 16-year-olds who applied to Big Brothers Big Sisters for mentors. More than 60 percent of them were boys; more than half were members of minority groups, mostly African American. Over 80 percent came from impoverished families, approximately 40 percent were from homes with a history of drug or alcohol abuse, and almost all were being raised by a single parent. Half of these young people were matched with a mentor, while the rest stayed on the waiting list. Eighteen months later, the differences between the two groups were surprising: weekly meetings with a mentor for (on average) a year had reduced first-time drug use by almost half and first-time alcohol use by a third, had cut school absenteeism by half, improved parental and peer relationships, and gave the youth confidence in doing their school work

Big Brothers/Big Sisters: A Study of Volunteer Recruitment and Screening

This is one of four P/PV reports on mentoring programs associated with Big Brothers/Big Sisters of America (BBBSA). It describes how BBBS agencies recruit potential volunteers, who is most likely to respond to current outreach efforts, and which techniques are used to attract minority volunteers. The study also investigates the intake process and makes recommendations for its improvement

Launching AmeriCorps: First-Year Implementation of the National and Community Service Trust Act of 1993

The National and Community Service Trust Act of 1993 spurred the creation and expansion of national service activities throughout the US, relying on the states to determine how best to implement programs locally. P/PV undertook a long-term study to document this process, paying particular attention to the nature and progress of the federal-state relationship that the Act employed to get programs up and running quickly throughout the country. This report chronicles the first year of implementation, drawing on extensive interviews with key staff members of the Corporation for National Service, state commission heads and board members, and on observations of implementation activities in nine of the participating states. A close review of developments at both the policy and implementation levels reflects the challenges and opportunities presented by the joint federal-state approach, as well as the extent to which states were able to get programs up and running quickly to satisfy this ambitious legislative mandate

Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny

SummaryHematopoietic stem cells (HSCs) continuously regenerate the hematologic system, yet few genes regulating this process have been defined. To identify candidate factors involved in differentiation and self-renewal, we have generated an expression database of hematopoietic stem cells and their differentiated progeny, including erythrocytes, granulocytes, monocytes, NK cells, activated and naive T cells, and B cells. Bioinformatic analysis revealed HSCs were more transcriptionally active than their progeny and shared a common activation mechanism with T cells. Each cell type also displayed unique biases in the regulation of particular genetic pathways, with Wnt signaling particularly enhanced in HSCs. We identified ∼100–400 genes uniquely expressed in each cell type, termed lineage “fingerprints.” In overexpression studies, two of these genes, Zfp105 from the NK cell lineage, and Ets2 from the monocyte lineage, were able to significantly influence differentiation toward their respective lineages, demonstrating the utility of the fingerprints for identifying genes that regulate differentiation

Uphold the nuclear weapons test moratorium

The Trump administration is considering renewing nuclear weapons testing (1), a move that could increase the risk of another nuclear arms race as well as an inadvertent or intentional nuclear war. Following in the long tradition of scientists opposing nuclear weapons due to their harmful effects on both humanity and the planet (2), we ask the U.S. government to desist from plans to conduct nuclear tests. During the Cold War, the United States conducted 1030 nuclear weapons tests, more than all other nuclear-armed nations combined (3). In 1996, the United States signed the Comprehensive Nuclear Test Ban Treaty (CTBT), agreeing not to conduct a nuclear weapons test of any yield (4). The United States has not yet ratified the CTBT but did spearhead the 2016 adoption of UN Security Council Resolution 2310, which calls upon all countries to uphold the object and purpose of the CTBT by not conducting nuclear tests (5). Eight of the nine nuclear-armed states, including the five permanent members of the UN Security Council, have observed a moratorium on nuclear testing since 1998 (3, 4). The ninth, North Korea, responding to international pressure, stopped testing warhead detonations (as opposed to missile flights) in 2017 (6). If the United States ratified the CTBT, joining the 168 countries who have already done so (4), there is a good chance that the other holdout countries would ratify the treaty as well (7)

Uphold the nuclear weapons test moratorium

The Trump administration is considering renewing nuclear weapons testing (1), a move that could increase the risk of another nuclear arms race as well as an inadvertent or intentional nuclear war. Following in the long tradition of scientists opposing nuclear weapons due to their harmful effects on both humanity and the planet (2), we ask the U.S. government to desist from plans to conduct nuclear tests. During the Cold War, the United States conducted 1030 nuclear weapons tests, more than all other nuclear-armed nations combined (3). In 1996, the United States signed the Comprehensive Nuclear Test Ban Treaty (CTBT), agreeing not to conduct a nuclear weapons test of any yield (4). The United States has not yet ratified the CTBT but did spearhead the 2016 adoption of UN Security Council Resolution 2310, which calls upon all countries to uphold the object and purpose of the CTBT by not conducting nuclear tests (5). Eight of the nine nuclear-armed states, including the five permanent members of the UN Security Council, have observed a moratorium on nuclear testing since 1998 (3, 4). The ninth, North Korea, responding to international pressure, stopped testing warhead detonations (as opposed to missile flights) in 2017 (6). If the United States ratified the CTBT, joining the 168 countries who have already done so (4), there is a good chance that the other holdout countries would ratify the treaty as well (7)

Signal Transmission in the Auditory System

Contains table of contents for Section 3, an introduction and reports on six research projects.National Institutes of Health Grant R01-DC-00194National Institutes of Health Contract P01-DC-00119National Institutes of Health Fellowship F32-DC00073National Institutes of Health Grant R01-DC00238National Institutes of Health Grant R01-DC00473National Institutes of Health Grant T32-DC00006National Institutes of Health Grant T32-DC00038National Institutes of Health Contract P01-DC00361National Institutes of Health Grant R01-DC00235National Institutes of Health Contract N01-DC2240

Signal Transmission in the Auditory System

Contains table of contents for Section 3, an introduction and reports on six research projects.National Institutes of Health Grant R01-DC-00194-11National Institutes of Health Grant P01-DC00119 Sub-Project 1National Institutes of Health Grant F32-DC00073-2National Institutes of Health Contract P01-DC00119National Institutes of Health Grant R01-DC00238National Institutes of Health Gramt R01-DC00473National Institutes of Health Grant P01-DC00119National Institutes of Health Grant T32-DC00038PNational Institutes of Health Grant P01-DC00361National Institutes of Health Grant 2RO1 DC00235National Institutes of Health Contract NO1-DC2-240