Inequalities in Income, Labor, and Education: The Challenge of Inclusive Growth

While economic growth is important for poverty reduction, the rather stellar performance of the Philippines in economic growth has still not translated into reduction of poverty. This is in large part due to issues pertaining to distribution. Inequalities in income, as well as inequities in labor and education, have provided barriers for everyone to participate in growth processes. The study looks at trends in various statistics on poverty and income distribution, and then examines how disparities in opportunities across rural/urban areas, between the sexes, and between the poorest and richest segments of society in labor and education have prevented the country from reducing poverty. It also examines why the conditional cash transfer program can provide opportunities toward more social and economic inclusiveness

Migration & Self-Rated Health: Comparing Occupational Cohorts in California & Spain (MICASA and ITSAL Projects)

International migration is a growing global phenomenon.  The magnitude of the global population living outside their countries of origin substantiates the value of considering potential public health issues and their population-wide burden.  As migration has yet to be generally accepted as an exposure in and of itself, and encompasses a wide range of experiences and health effects, a measure of overall health is well suited for this research. This study compares self-rated health between two independently collected occupational cohorts as part of the ITSAL study in Spain and the MICASA study in Mendota, California, USA.  We observed greater gender balance in the MICASA sample than the ITSAL sample, where there was a substantial male majority.  Mexican-born workers in the MICASA sample tended to be older, less educated, and more likely to work in agriculture than their Moroccan-born counterparts in the ITSAL study.  We also observed a higher prevalence of poor self-rated health in the MICASA sample compared to the ITSAL sample.  Differences may be due to sampling and data collection issues, cultural issues and the subjectivity of self-rated health as an outcome, as well as actual health differences.  Further research is needed to determine common and distinct migration-related public health issues.L'immigration internationale est un phénomène mondial en plein essor. Le pourcentage élevé de personnes dans le monde vivant dans un pays autre que son pays d'origine justifie l'intérêt de prendre en compte les problèmes de santé publique potentiels et le fardeau que cela implique à l'échelle de la population. Alors que l'immigration n'est pas encore généralement reconnue comme une exposition en soi, et englobe un large éventail d'expériences et d'effets sur la santé, une évaluation de la santé globale est tout à fait appropriée pour cette étude. Cette étude compare la santé auto-évaluée de deux cohortes professionnelles, les donnés ayant été recueillies indépendamment dans le cadre de l'étude ITSAL en Espagne et de l'étude MICASA à Mendota, en Californie. Nous avons observé un plus grand équilibre entre les sexes dans l'échantillon MICASA que dans l'échantillon ITSAL, dans lequel il y avait une majorité considérable d'hommes. Les ouvriers de l'échantillon MICASA nés au Mexique avaient tendance à être plus âgés, à avoir un niveau d'instruction moindre, et à être plus susceptibles de travailler dans l'agriculture que leurs homologues nés au Maroc de l'étude ITSAL. Nous avons également observé une plus forte prévalence de mauvaise santé auto-évaluée dans l'échantillon MICASA que dans l'échantillon ITSAL. Les différences peuvent être dues aux méthodes d'échantillonnage et de recueil des données, à des aspects culturels et à la subjectivité des résultats de la santé auto-déclarée, ainsi qu'à de réelles différences en matière de santé. D'autres études sont nécessaires pour déterminer les problèmes de santé publique liées à l'immigration communs et distincts.La migración internacional es un fenómeno creciente a nivel mundial. La magnitud de la población mundial que vive fuera de su país de origen justifica el valor del estudio de los problemas potenciales para la salud pública y la carga que supone para la población en general. Debido a que todavía no se ha aceptado de forma generalizada que la migración supone una exposición por sí misma y al hecho de que abarca una amplia gama de experiencias y efectos para la salud, una medición de la salud en general parece apropiada para este estudio. En este trabajo se compara la autoevaluación de la salud entre dos cohortes ocupacionales analizadas independientemente como parte del estudio ITSAL en España y el estudio MICASA en Mendota (California, Estados Unidos.). Hemos observado un mayor equilibrio entre sexos en la muestra de MICASA que en la de ITSAL, donde había una importante mayoría masculina. Los trabajadores de origen mexicano de la muestra de MICASA tendían a ser mayores, con menor nivel educativo y con mayor probabilidad de trabajar en la agricultura que los colegas de origen marroquí del estudio ITSAL. Asimismo, hemos observado una mayor prevalencia de salud deficiente en la muestra de MICASA en comparación con la muestra de ITSAL. Las diferencias pueden deberse a problemas de muestreo y de recopilación de datos, a aspectos culturales y a la subjetividad de los resultados de la autoevaluación de la salud, así como a verdaderas diferencias de salud. Asimismo, es necesario realizar otros estudios para determinar qué aspectos de salud pública relacionados con la migración se comparten y cuáles son diferentes

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

A number of publications have described the use of adeno-associated virus (AAV) for the delivery of anti-HIV and anti-simian immunodeficiency virus (SIV) monoclonal antibodies (mAbs) to rhesus monkeys. Anti-drug antibodies (ADAs) have been frequently observed, and long-term AAV-mediated delivery has been inconsistent. Here, we investigated different AAV vector strategies and delivery schemes to rhesus monkeys using the rhesus monkey mAb 4L6. We compared 4L6 immunoglobulin G1 (IgG1) delivery using the AAV1 versus the AAV8 serotype with a cytomegalovirus (CMV) promoter and the use of a muscle-specific versus a liver-specific promoter. Long-term expression levels of 4L6 IgG1 following AAV8-mediated gene transfer were comparable to those following AAV1-mediated gene transfer. AAV1-mediated gene transfer, using a muscle-specific promoter, showed robust ADAs and transiently low 4L6 IgG1 levels that ultimately declined to below detectable levels. Intravenous AAV8-mediated gene transfer, using a liver-specific promoter, also resulted in low levels of delivered 4L6 IgG1, but those low levels were maintained in the absence of any detectable ADAs. Booster injections using AAV1-CMV allowed for increased 4L6 IgG1 serum levels in animals that were primed with AAV8 but not with AAV1. Our results suggest that liver-directed expression may help to limit ADAs and that re-administration of AAV of a different serotype can result in successful long-term delivery of an immunogenic antibody

Comparison of E-Textile Techniques and Materials for 3D Gesture Sensor with Boosted Electrode Design

[EN] There is an interest in new wearable solutions that can be directly worn on the curved human body or integrated into daily objects. Textiles offer properties that are suitable to be used as holders for electronics or sensors components. Many sensing technologies have been explored considering textiles substrates in combination with conductive materials in the last years. In this work, a novel solution of a gesture recognition touchless sensor is implemented with satisfactory results. Moreover, three manufacturing techniques have been considered as alternatives: screen-printing with conductive ink, embroidery with conductive thread and thermosealing with conductive fabric. The main critical parameters have been analyzed for each prototype including the sensitivity of the sensor, which is an important and specific parameter of this type of sensor. In addition, user validation has been performed, testing several gestures with different subjects. During the tests carried out, flick gestures obtained detection rates from 79% to 89% on average. Finally, in order to evaluate the stability and strength of the solutions, some tests have been performed to assess environmental variations and washability deteriorations. The obtained results are satisfactory regarding temperature and humidity variations. The washability tests revealed that, except for the screen-printing prototype, the sensors can be washed with minimum degradation.This work was supported by the Spanish Government/FEDER funds (RTI2018-100910-B-C43) (MINECO/FEDER). The work presented is also funded by the Conselleria d'Economia Sostenible, Sectors Productius i Treball, through IVACE (Instituto Valenciano de Competitividad Empresarial) and cofounded by ERDF funding from the EU. Application No.: IMAMCI/2020/1Ferri Pascual, J.; Llinares Llopis, R.; Martinez, G.; Lidon-Roger, JV.; Garcia-Breijo, E. (2020). Comparison of E-Textile Techniques and Materials for 3D Gesture Sensor with Boosted Electrode Design. Sensors. 20(8):1-19. https://doi.org/10.3390/s20082369S11920

NADPH Oxidase–Dependent Superoxide Production Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Atherosclerotic Disease

Objective—Oxidative stress plays a critical role in the pathogenesis of atherosclerosis. The NADPH oxidase constitutes the main source of superoxide in phagocytic and vascular cells. This study aimed to investigate the levels of NADPH oxidase–mediated superoxide production in phagocytic cells and the association between phagocytic superoxide production and carotid intima-media thickness (IMT), a surrogate marker of asymptomatic atherosclerosis. Methods and Results—NADPH oxidase–mediated superoxide production was determined by a chemiluminescence assay using lucigenin and associated with IMT for 184 asymptomatic subjects free of overt clinical atherosclerotic disease. Compared with individuals in the lowest tertile of superoxide production, those in the upper tertile ( 20 counts/sec) showed significantly higher IMT (P 0.05). In correlation analysis, a positive relationship was found between superoxide production and carotid IMT. Superoxide production also correlated positively (P 0.05) with body mass index (BMI). In multivariate analysis, the association of superoxide production with carotid IMT remained significant after adjustment for age, sex, systolic blood pressure, BMI, triglycerides, glucose, and smoking. Conclusions—In a population sample of adults without clinically overt atherosclerotic disease, increased NADPH oxidase activity was associated with enhanced carotid IMT, suggesting a relationship between phagocytic NADPH oxidase– mediated oxidative stress and the development of atherosclerosis