bioRxiv

Atrophy related to multiple sclerosis (MS) has been found at the early stages of the disease. However, the archetype dynamic trajectories of the neurodegenerative process, even prior to clinical diagnosis, remain unknown. We modeled the volumetric trajectories of brain structures across the entire lifespan using 40,944 subjects (38,295 healthy controls and 2649 MS patients). Then, we estimated the chronological progression of MS by assessing the divergence of lifespan trajectories between normal brain charts and MS brain charts. Chronologically, the first affected structure was the thalamus, then the putamen and the pallidum (around 4 years later), followed by the ventral diencephalon (around 7 years after thalamus) and finally the brainstem (around 9 years after thalamus). To a lesser extent, the anterior cingulate gyrus, insular cortex, occipital pole, caudate and hippocampus were impacted. Finally, the precuneus and accumbens nuclei exhibited a limited atrophy pattern. Subcortical atrophy was more pronounced than cortical atrophy. The thalamus was the most impacted structure with a very early divergence in life. Our experiments showed that lifespan models of most impacted structures could be an important tool for future preclinical/prodromal prognosis and monitoring of MS. © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.Apprentissage profond pour la volumétrie cérébrale : vers le BigData en neuroscienceTranslational Research and Advanced Imaging LaboratoryInitiative d'excellence de l'Université de Bordeau

Multi-interface network framework for UAV management and data communications

Recent efforts to manage Unmanned Aerial Vehicle (UAV) operations in European civilian environments have resulted in the development of U-space, the European Union’s UAS Traffic Management (UTM) concept of operations. This paper presents the primary purposes of the H2020 Labyrinth project (mainly focusing on the communications architecture), which has as its main challenge to create and validate UAV applications through the research and development of pathplanning algorithms and new UTM services. In addition, this article performs a preliminary validation of a communications prototype (including three communication alternatives) with real equipment of the National Institute of Aerospace Technology (INTA) of the Spanish Ministry of Defense. The presented results show the functionality of the prototypes and serve as a starting point to develop the requirements defined in the communications architecture