VIAJANTES DO IMAGINÁRIO: A AMÉRICA VISTA DA EUROPA, SÉC. XV-XVII

VIAJANTES DO IMAGINÁRIO: A AMÉRICA VISTA DA EUROPA, SÉC. XV-XVI

Factors associated with the need for ventilation at birth of neonates weighing ≥2,500 g

OBJECTIVES: Approximately 20-40% of annual global neonatal deaths occur among infants with birthweights ≥2,500 g, and most of these deaths are associated with intrapartum asphyxia in low- and middle-income countries. This study aims to evaluate the peripartum variables associated with the need for resuscitation at birth of neonates weighing ≥2,500 g. METHOD: This case-control retrospective study was performed on data from all public reference maternity units in the state of Ceará, Northeast Brazil, between March 2009 and March 2010. The subjects were singleton neonates without malformations weighing ≥2,500 g, who required positive-pressure ventilation in the delivery room. The controls had a 1-minute Apgar score of ≥8 and did not undergo resuscitation. Variables associated with positive-pressure ventilation in the delivery room were evaluated via conditional multivariate logistic regression. RESULTS: Of the 2,233 live births with birth weights ≥2,500 g, 1-minute Apgar scores ≤7, and no malformations, 402 patients met the inclusion criteria, and they were paired with 402 controls. Risk variables for positive-pressure ventilation at birth were a gestational ag

Amphibia, Anura, Leptodactylidae, Leptodactylus syphax Bokermann, 1969: distribution extension and geographic distribution map

Leptodactylus syphax is a mid-sized frog that inhabits open rocky areas in central, southeastern and northeastern Brazil, besides southern Paraguay and eastern Bolivia. Here we reported an adult male from Parque Municipal Cachoeira do Bota Fora, Piripiri municipality, state of Piauí, northeastern Brazil, expanding the known distribution of Leptodactylus syphax ca. 320 km northwards

Entre aspecto e negação A heterossemia de [deixar+de+vinf.]

Fundamentados nas premissas teórico-metodológicas dos Modelos Baseados no Uso (Bybee 2016; Goldberg 1995, 2006; Traugott & Trousdale 2013), analisamos, neste artigo, a microconstrução [deixar+de+Vinf.] dos domínios semânticos de aspecto e de polaridade. Por estarem ligadas, via elo de heterossemia (Lichetenberk 1991), em diferentes redes taxionômicas do português, mostramos que essas microconstruções se originam da construção transitiva com o verbo deixar, cujo significado central é o de afastamento. Descrevemos as singularidades das microconstruções por meio de análise diacrônica, quantitativa e qualitativa, dos parâmetros tipo de entidade semântica representada pelo sujeito da microconstrução e tipo semântico de Vinf., tendo por base dados extraídos do Corpus do Português (Davis & Ferreira 2006, 2016). Os resultados nos permitem comprovar, ao final, a hipótese de que essas microconstruções surgem via relações com outras já existentes e se abstratizam gradativamente, ao sancionarem uma maior variedade de tipos semânticos de sujeito e de Vinf..Founded on the theoretical and methodological premises of the Usage-Based Models (Bybee 2016; Goldberg 1995, 2006; Traugott & Trousdale 2013), in this paper, we analyze the micro-construction [deixar+de+Vinf.] from the semantic domains of aspect and polarity. Since they are linked, by a heterosemy link (Lichetenberk 1991), in different taxonomic networks of Portuguese, we demonstrate that these micro-constructions originate from the transitive construction with the verb deixar, whose central meaning is distancing. Based on data extracted from the Corpus do Português (Davis & Ferreira 2006, 2016), we describe the singularities of the micro-constructions through a diachronic quantitative and qualitative analysis of parameters semantic entity type represented by the subject of the micro-construction and semantic type of Vinf.,. At the end, the results allow us to prove the hypothesis that these micro-constructions emerge from relations with other ones already existing and they gradually abstract sanctioning a greater variety of semantic subject and Vinf. types

Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides

Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide. This last step takes advantage of the electrophilic feature of the MBH residue and represents a new cyclization strategy occurring. The analogues were prepared in moderate overall yields and did not show toxic effects on Staphylococcus aureus growth and were not toxic to human fibroblasts. Two of them inhibited the hemolytic activity of S. aureus, suggesting an interfering action in the bacterial quorum sensing similar to the one already reported for solonamides

Mineração de dados aplicada a métodos de seleção de variáveis para a modelagem de estoque de carbono acima do solo

The objective of this work was to apply the random forest (RF) algorithm to the modelling of the aboveground carbon (AGC) stock of a tropical forest by testing three feature selection procedures – recursive removal and the uniobjective and multiobjective genetic algorithms (GAs). The used database covered 1,007 plots sampled in the Rio Grande watershed, in the state of Minas Gerais state, Brazil, and 114 environmental variables (climatic, edaphic, geographic, terrain, and spectral). The best feature selection strategy – RF with multiobjective GA – reaches the minor root-square error of 17.75 Mg ha-1 with only four spectral variables – normalized difference moisture index, normalized burn ratio 2 correlation texture, treecover, and latent heat flux –, which represents a reduction of 96.5% in the size of the database. Feature selection strategies assist in obtaining a better RF performance, by improving the accuracy and reducing the volume of the data. Although the recursive removal and multiobjective GA showed a similar performance as feature selection strategies, the latter presents the smallest subset of variables, with the highest accuracy. The findings of this study highlight the importance of using near infrared, short wavelengths, and derived vegetation indices for the remote-sense-based estimation of AGC. The MODIS products show a significant relationship with the AGC stock and should be further explored by the scientific community for the modelling of this stock.O objetivo deste trabalho foi aplicar o algoritmo “random forest” (RF) à modelagem do estoque de carbono acima do solo (CAS) de uma floresta tropical, por meio da testagem de três procedimentos de seleção de variáveis: remoção recursiva e algoritmos genéticos (AGs) uniobjetivo e multiobjetivo. Os dados utilizados abrangeram 1.007 parcelas amostradas na bacia hidrográfica do Rio Grande, no estado de Minas Gerais, Brasil, e 114 variáveis ambientais (climáticas, edáficas, geográficas, de terreno e espectrais). A melhor estratégia de seleção de variáveis – a RF com AG multiobjetivo – chega ao menor erro quadrático de 17,75 Mg ha-1 com apenas quatro variáveis espectrais – índice de umidade por diferença normalizada, textura de correlação do índice de queimada por razão normalizada 2, cobertura arbórea e fluxo de calor latente –, o que representa redução de 96,5% no tamanho do banco de dados. As estratégias de seleção de variáveis ajudam a obter melhor desempenho da RF, ao melhorar a acurácia e reduzir o volume dos dados. Embora a remoção recursiva e o AG multiobjetivo mostrem desempenho semelhante como estratégias de seleção de variáveis, esta último apresenta menor subconjunto de variáveis, com maior precisão. As descobertas deste trabalho destacam a importância do uso de infravermelho próximo, comprimentos de onda curtos e índices de vegetação derivados para a estimativa de CAS baseada em sensoriamento remoto. Os produtos MODIS mostram relação significativa com o estoque de CAS e precisam ser melhor explorados pela comunidade científica para a modelagem deste estoque

Localization of the tibial entry point

OBJETIVE: To assess, through a questionnaire, the intramedullary nail entry point in the proximal aspect of the tibia. Me-thods: 230 attendees who treat tibial fractures were interviewed. The questionnaire was created with three sections that could be answered with Yes or No answers and a fourth section that had two figures representing anteroposterior (AP) and lateral view x-rays that could be answered with a format A, B or C. RESULTS: The most frequent reason was ease of access (67.8%), followed by the better nail insertion access (60.9%) and the third one was to prevent knee pain (27.4%). Reasons for choosing access so as to prevent knee pain and prevent tendinitis had a significant relationship with points A and C of the schematic figure in the AP x-ray, especially C (medial tibial crest). No significant difference was observed between types of access to the patellar ligament in the schematic figure of the AP and lateral x-ray among age groups. CONCLUSION: The greater the age, the larger the proportion choosing the question avoid valgus deformity. Reasons from a medical (practical) perspective were related to the type of access in the transpatellar ligament, while reasons from a patient (functional) perspective were related to medial parapatellar access. Transpatellar access was chosen by most participants (66.5%).OBJETIVO: Verificar, através de um questionário, o ponto de entrada da haste intramedular na região proximal da tíbia. Métodos: 230 participantes que tratam fraturas da tíbia foram entrevistados. O questionário foi formulado com três segmentos que poderiam ser respondidos com um formato sim ou não e um quarto, com duas figuras que representavam uma radiografia em anteroposterior (AP) e lateral que poderiam ser respondidas com um formato A, B ou C. RESULTADOS: A razão mais frequente foi a facilidade de acesso (67,8%), seguida do melhor acesso para inserção da haste (60,9%) e em terceiro prevenir a dor no joelho (27,4%). Existiu relação significativa entre as razões de escolha do acesso como prevenir dor no joelho e evitar tendinites com os pontos A e C da figura esquemática de radiografia em AP, principalmente o ponto C (crista tibial medial). Observou-se que não existiu diferença significativa nos tipos de acesso em relação ao ligamento patelar, nas figuras esquemáticas de radiografia em AP e perfil entre as faixas etárias. CONCLUSÃO: Observou-se que quanto maior a faixa etária maior a proporção de escolher a pergunta evitar deformidade em valgo. As razões de aspecto médico (prático) foram relacionadas com o tipo de acesso no ligamento transpatelar, enquanto que as razões de aspecto paciente (funcional) foram relacionadas com o acesso parapatelar medial. O acesso transpatelar foi escolhido pela maioria dos participantes (66,5%).Universidade Federal de São Paulo (UNIFESP)Hospital Santa TeresaUniversidade Federal do Rio de Janeiro Faculdade de Medicina Departamento de Ortopedia e TraumatologiaHospital de IpanemaSanta Casa de São Paulo Faculdade de Ciências MedicasSanta Casa de São Paulo da Faculdade de CiênciasUNIFESPSciEL

Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine

The antimicrobial peptide dermaseptin 01 (DS 01), from the skin secretion of Phyllomedusa hypochondrialis frogs, was immobilized in nanostructured layered films in conjunction with nickel tetrasulfonated phthalocyanines (NiTsPc), widely used in electronic devices, using layer-by-layer technique. The films were used as a biosensor to detect the presence of dopamine (DA), a neurotransmitter associated with diseases such as Alzheimer's and Parkinson's, with detection limits in the order of 10−6 mol L−1. The use of DS 01 in LbL film generated selectivity in the detection of DA despite the presence of ascorbic acid found in biological fluids. This work is the first to report that the antimicrobial peptide and NiTsPc LbL film exhibits electroanalytical activity to DA oxidation. The selectivity in the detection of DA is a fundamental aspect for the development of electrochemical sensors with potential applications in the biomedical and pharmaceutical industries

Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine

The antimicrobial peptide dermaseptin 01 (DS 01), from the skin secretion of Phyllomedusa hypochondrialis frogs, was immobilized in nanostructured layered films in conjunction with nickel tetrasulfonated phthalocyanines (NiTsPc), widely used in electronic devices, using layer-by-layer technique. The films were used as a biosensor to detect the presence of dopamine (DA), a neurotransmitter associated with diseases such as Alzheimer's and Parkinson's, with detection limits in the order of 10−6 mol L−1. The use of DS 01 in LbL film generated selectivity in the detection of DA despite the presence of ascorbic acid found in biological fluids. This work is the first to report that the antimicrobial peptide and NiTsPc LbL film exhibits electroanalytical activity to DA oxidation. The selectivity in the detection of DA is a fundamental aspect for the development of electrochemical sensors with potential applications in the biomedical and pharmaceutical industries