Vascular Malformation of the Face: a Rare Case with Follow-up of 18 Years

Svrha rada: Vaskularne malformacije strukturne su anomalije krvnih žila. Prisutne su od rođenja i ostaju cijeli život. Mogu se klasificirati prema vrsti žila koje zahvaćaju. Tako su vinski madeži vaskularne malformacije koje obilježava povećan broj ektatičnih žila u dermalnom vaskularnom pleksusu, a mogu se nalaziti na bilo kojem dijelu tijela, uključujući i područje glave i vrata. Tijekom godina većina tih mrlja potiče hipertrofiju mekog tkiva, pa taj rast može uzrokovati tešku deformaciju lica. Materijali i metode: U ovom radu opisan je rijedak slučaj divovske proliferativne vaskularne anomalije koja je nastala od vinskog madeža na licu. Rezultati: U prikazu se naglasak stavlja na kontinuirani i proliferativni rast lezije koja je praćena 18 godina te na poteškoće pri utvrđivanju dijagnoze zbog njezine složenosti i dimenzije te okolnosti povezanih s lošim socijalno-ekonomskim statusom pacijenata. Zaključak: Opisujemo rijedak i neuobičajen slučaj divovske proliferativne vaskularne malformacije koja potječe od vinskog madeža na licu.Objective: Vascular malformations are structural anomalies in the blood vessels. They are present at birth and persist throughout life. These malformations can be classified according to the type of vessel involved. A port-wine stain is a vascular malformation characterized by an increased number of ectatic vessels in the dermal vascular plexus, which can be found in any part of the body, including the head and neck region. Over time, most of these stains result in soft tissue hypertrophy and this growth can cause severe facial deformity. Materials and Methods: This study describes a rare case of a giant proliferative vascular anomaly arising from a port-wine stain on the face. Results: The report highlights the continuous and proliferative growth of the malformation observed after follow-up of 18 years, as well as the difficulty in establishing the diagnosis due to the complexity and dimension of the lesion and the conditions related to the patient’s low socioeconomic status. Conclusions: We have described a rare and unusual case report of a giant proliferative vascular malformation arising from a Port-wine stain on the face

Estudo comparativo dos métodos de cálculo semiempíricos com os ensaios de carregamento dinâmico e carregamento estático, estudo de caso de edifícios altos com fundação de perfis metálicos / Comparative study of semi-empirical calculation methods with dynamic loading tests and static loading tests, case study of tall buildings with foundation of metallic profiles

O estudo se resume em a comparação dos resultados dos Ensaios, in loco, Dinâmico e de Carregamento Lento (este último que necessitou ser extrapolados pelo método de Van Der Veen, de acordo com a NBR 6122), com os métodos de cálculo semiempíricos de Aoki-Velloso e Decourt-Quaresma. Para tal, foram usadas como dados dez estacas de perfil metálico tipo I na fundação de um prédio comercial na região sul da cidade de Belém do Pará, onde a estratigrafia é composta por camadas intercaladas de areias compactadas à compactas medias e argilas mole à rijas. A metodologia do estudo se deu pela comparação dos valores de carga mobilizada perante os parâmetros de transferência de carga. Com base nos resultados foram gerados gráficos de força mobilizada em relação ao deslocamento. Foram atingidos resultados satisfatórios, levando-se em comparação o comprimento das estacas, com proximidade aos valores dos métodos de Aoki-Velloso e Decourt-Quaresma

Evaluation of peripheral nerve fibers and mast cells in burning mouth syndrome

Abstract Emerging evidence has revealed a cross-talk in the etiopathogenesis of burning mouth syndrome (BMS) related to peripheral nerve fibers (NF) and neuropeptides secreted by mast cells. Here, we investigated the S-100+ density and PGP 9.5+ integrity of peripheral NF and the tryptase+ mast cell density in the oral mucosa of BMS patients and healthy individuals. A total of 23 oral mucosa specimens (12 BMS and 11 controls) were evaluated. The clinical diagnosis of BMS was based on a careful examination, excluding other local and systemic causes. Samples were taken from an incisional biopsy of the tongue mucosa of individuals with symptomatic BMS, while the margins of the non-neoplastic tongue biopsy served as controls of healthy individuals. Immunohistochemistry was performed to determine the density/mm2 of S-100+, PGP 9.5+ peripheral NF, and tryptase+ mast cells. Similar densities of S-100+, PGP 9.5+ peripheral NF, and tryptase+ mast cells were found in cases of BMS, with a median value of 3.70, 0.70, and 29.24/mm2, respectively, and in the control group, with a median value of 2.60, 0.80, and 26.01/mm2, respectively (p > 0.05). Moreover, the relationship between S100+ and PGP 9.5+ peripheral NF was the same in both groups (p = 0.70). This study demonstrated that there were no alterations in the density and integrity of peripheral NF in the tongue of symptomatic BMS patients. However, the sensitization of peripheral NF in this disease may not depend on mast cell density

Photobiomodulation Therapy in the Proliferation and Differentiation of Human Umbilical Cord Mesenchymal Stem Cells: An In Vitro Study

Introduction: Since photobiomodulation therapy (PBMT) favors in vitro mesenchymal stem cell (MSC) preconditioning before MSC transplantation, increasing the proliferation of these cells without molecular injuries by conserving their characteristics, in the present in vitro study we analyzed the effect of PBMT on the proliferation and osteogenic differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs).Methods: Irradiation with an InGaAIP Laser (660 nm, 10 mW, 2.5 J/cm2, 0.08 cm2 spot size, and 10 s) was carried out. The cells were divided into four groups: CONTROL [cells grown in Dulbecco’s Modified Eagle Medium (DMEM)], OSTEO (cells grown in an osteogenic medium); PBMT (cells grown in DMEM+PBMT), and OSTEO+PBMT (cells grown in an osteogenic medium-plus PBMT). The cell proliferation curve was obtained over periods of 24, 48 and 72 hours using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Osteogenic differentiation was analyzed by the formation of calcium nodules over periods of 7, 14 and 21 days. Morphometric analysis was performed to quantify the total area of nodular calcification.Results: The highest cell proliferation and cell differentiation occurred in the OSTEO+PBMT group, followed by the PBMT, OSTEO, and CONTROL groups respectively, at the observed times (P < 0.05).Conclusion: PBMT enhanced the osteogenic proliferation and the differentiation of hUCMSCs during the periods tested, without causing damage to the cells and preserving their specific characteristics, a fact that may represent an innovative pretreatment in the application of stem cells

Analysis of Dental Enamel Surface Submitted to Fruit Juice Plus Soymilk by Micro X-Ray Fluorescence: In Vitro

Objective. This paper aimed to analyze the in vitro industrialized fruit juices effect plus soy to establish the erosive potential of these solutions. Materials and Methods. Seventy bovine incisors were selected after being evaluated under stereomicroscope. Their crowns were prepared and randomly divided into 7 groups, using microhardness with allocation criteria. The crowns were submitted to the fruit juice plus soy during 15 days, twice a day. The pH values, acid titration, and Knoop microhardness were recorded and the specimens were evaluated using X-ray microfluorescence (µXRF). Results. The pH average for all juices and after 3 days was significantly below the critical value for dental erosion. In average, the pH value decreases 14% comparing initial time and pH after 3 days. Comparing before and after, there was a 49% microhardness decrease measured in groups (p<0.05). Groups G1, G2, G5, and G6 are above this average. The analysis by μXRF showed a decrease of approximately 7% Ca and 4% P on bovine crowns surface. Florida (FL) statistical analysis showed a statistically significant 1 difference between groups. Thus, a tooth chance to suffer demineralization due to industrialized fruit juices plus soy is real

Calcifying odontogenic cyst: a multicenter study

Submitted by Rafael Paula ([email protected]) on 2019-10-11T18:07:40Z No. of bitstreams: 1 Dissertação José Alcides .pdf: 6345209 bytes, checksum: 26e7d3daed18a95af5871c88f89f5546 (MD5)Approved for entry into archive by Eliane Andrade ([email protected]) on 2019-10-14T14:54:33Z (GMT) No. of bitstreams: 1 Dissertação José Alcides .pdf: 6345209 bytes, checksum: 26e7d3daed18a95af5871c88f89f5546 (MD5)Made available in DSpace on 2019-12-11T19:24:37Z (GMT). No. of bitstreams: 1 Dissertação José Alcides .pdf: 6345209 bytes, checksum: 26e7d3daed18a95af5871c88f89f5546 (MD5) Previous issue date: 2019-07-03CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorEste estudo investigou a frequência do cisto odontogênico calcificante (COC) submetido à análise histopatológica em diferentes regiões geográficas do Brasil. Em uma análise retrospectiva (1953-2016), arquivos de biópsias de 10 centros de Patologia Oral e Maxilofacial localizados em diferentes estados do Brasil: Goiás, Minas Gerais, Pará, Rio de Janeiro, Rio Grande do Norte, Rio Grande do Sul, Santa Catarina e São Paulo foram analisados. Dados demográficos, características clinicopatológicas, aspectos radiográficos e tipos de biópsia foram avaliados descritivamente. O teste Mann-Whitney foi utilizado para determinar a associação entre sintomas, tempo de evolução e tamanho da lesão. A significância estatística foi estabelecida como p<0,05. O diagnóstico do COC foi de acordo com a classificação da Organização Mundial de Saúde (2017). Adicionalmente, uma revisão da literatura de série de casos de COC foi realizada em quatro bases de dados eletrônicas (PubMed, Medline Ovid, Web of Science e Scopus). Dos 198.350 espécimes de biopsias exploradas, 268 casos de COC foram avaliados, representando 0,1% das lesões orais dos centros estudados. Em geral, indivíduos do sexo feminino (n=142, 54.0%), na segunda década de vida (n=76, 31.0%) com acometimento da maxila (n=141, 54.4%) foram os mais afetados. O tamanho médio das lesões dos indivíduos sintomáticos foi maior que o dos casos assintomáticos (p=0,026). A revisão da literatura apresentou maior frequência dos casos de COC na Ásia (186 casos) e na Europa (68 casos), acometendo principalmente os homens (n=247, 56.2%) na terceira década de vida. O COC é uma lesão rara. Novos dados sobre as características clinicopatológicas de 268 casos foram adicionados à literatura. Os dados referentes ao gênero e idade dos pacientes brasileiros aqui relatados são diferentes dos achados de séries de casos relatados já na literatura. Este estudo fornece informações que podem ajudar os clínicos, patologistas e cirurgiões no diagnóstico e manejo do COC.This study investigated the frequency of calcifying odontogenic cyst (COC) submitted to histopathological analysis in different geographic regions of Brazil. In a retrospective analysis (1953-2016), biopsy files of 10 Oral and Maxillofacial Pathology centers located in different states of Brazil: Goiás, Minas Gerais, Pará, Rio de Janeiro, Rio Grande do Norte, Rio Grande do Sul, Santa Catarina and São Paulo were analyzed. Demographic data, clinicopathological characteristics, radiographic aspects and treatment were evaluated descriptively. The Mann-Whitney test was used to determine the association between symptoms, evolution time and lesion size. Statistical significance was set as p<0.05. The diagnosis of COC was according to the classification of the World Health Organization (2017). In addition, a literature review of case series was carried out in four electronic databases (PubMed, Medline Ovid, Web of Science and Scopus). Of 198,350 specimens of biopsies analyzed, 268 cases of COC were surveyed, representing 0.1% of the oral lesions at the centers studied. Overall, female patients (n=142, 54.0%) in their second decade of life (n=76, 31.0%) and the maxilla (n=141, 54.4%) were more affected. The mean lesion size of symptomatic individuals was larger than that of cases without symptoms (p=0.026). The literature review showed a higher frequency in Asia (186 cases) and Europe (68 cases), mainly affecting men (n=247, 56.2%) in the third decade of life. COC is a rare lesion. Additional data on the clinicopathological features of 268 cases have been added to the literature. Data regarding gender and age of the Brazilian patients reported herein are different with findings of case series and retrospective studies reported in the literature. This study provides information that could help clinicians, pathologists, and surgeons in the diagnosis and management of COC

Smart IoT lysimetry system by weighing with automatic cloud data storage

Water is an essential resource for human life and for agricultural food production, climate change and the increased demand for water resources, has already impacted the availability of this resource in the world, in view of future forecasts of scarcity its rational use will be increasingly demanded. Thus, more efficient irrigation systems that optimize water use and reduce water loss will be important tools to help agriculture in the future. This work aims to develop and calibrate an intelligent and autonomous system for determining reference evapotranspiration (ETo), and precise irrigation control optimized for IoT operation, with data storage in a cloud database. Intelligent system integrates: mechanical weighing lysimeter; sensors and actuators commanded by a digital controller based on a microcontroller platform, connected to the internet through a Wi-Fi communication interface to cloud computing services models: platform as a service (PaaS) and software as a service (SaaS). The operation test results reveal that the system is capable of accurately measuring ET O values, consistent with the values estimated by the FAO-56 standard method, with high sensitivity and precision for determining mass variations, with an R² Correlation coefficient = 0.999321, and coefficient of determination of adjusted R² of 0.999321. Being a viable option for application in precision agriculture

Cervical Necrotizing Fasciitis Caused by Dental Extraction

Cervical necrotizing fasciitis is an unusual infection characterized by necrosis of the subcutaneous tissue and fascial layers. Risk factors for the development of necrotizing fasciitis include diabetes mellitus, chronic renal disease, peripheral vascular disease, malnutrition, advanced age, obesity, alcohol abuse, intravenous drug use, surgery, and ischemic ulcers. This report presents a case of necrotizing fasciitis in the cervical area caused by dental extraction in a 73-year-old woman. Cervical necrotizing fasciitis in geriatric patient is rare, and even when establishing the diagnosis and having it timely treated, the patient can suffer irreversible damage or even death. Clinical manifestations in the head and neck usually have an acute onset characterized by severe pain, swelling, redness, erythema, presence of necrotic tissue, and in severe cases obstruction of the upper airways. Therefore, the presentation of this clinical case can serve as guidance to dentists as a precaution to maintain an aseptic chain and be aware of the clinical condition of older patients and the systemic conditions that may increase the risk of infections

Persistent Necrotizing Mediastinitis after Dental Extraction

Mediastinitis is a rare, progressive, and destructive infectious process due to cervical or odontogenic infections, which, if not diagnosed early, may lead to several complications, including airway involvement and even an imminent risk of death. Herein, we report an unusual case of a 37-year-old male with a bilateral submandibular hard swelling after the left third molar extraction. After surgical intervention with submandibular drainage and antibiotic therapy, the infection persisted without explanation, since the patient was not hypertensive, did not have diabetes mellitus or sexually transmitted infections such as HIV or syphilis, and did not smoke or drink alcoholic beverages. A thoracic surgeon then intervened, treating the mediastinitis surgically by drainage, thus obtaining a significant improvement of the patient’s health. Mediastinitis is a serious condition. Clinicians and maxillofacial surgeons should be alert to make an immediate diagnosis and select the appropriate treatment in order to prevent worsening of the patient’s clinical condition