Do Major Currency Trading Volumes Explain the Rise of Bitcoin’s Price?

We examine the determinants of the Bitcoin price over the period from September 2012 to September 2017.  Unlike conventional currency demand models, trading volume is negatively related to the Bitcoin price and the frequency of Internet searches for the term Bitcoin is positively associated with the price.  We find strong and significant time trends in the Bitcoin price. These results suggest that the rise in Bitcoin’s price during our observation period was driven largely by speculation

Quadriceps Tendon Repair Using Double-Row Suture Anchor Fixation

Quadriceps tendon ruptures compromise the knee extensor mechanism and cause an inability to ambulate and significant functional limitations. Therefore, the vast majority of quadriceps tendon ruptures are indicated for operative intervention to restore patient mobility and function. Although these injuries were traditionally repaired using a transosseous repair technique, recent literature has shown that suture anchor repair may offer biomechanical advantages. Additionally, research in other areas of orthopaedics has found that a double-row suture anchor construct can offer additional biomechanical strength to tendinous repair. This technical note describes a safe and effective quadriceps tendon repair using a double-row suture anchor construct

Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study

Background: Lung cancer is the leading cause of cancer-related death globally. Physical activity and exercise provide unequivocal benefits to those living with and beyond lung cancer. However, few of those living with and beyond cancer meet the national physical activity guidelines. Various barriers exist for this population’s engagement in physical activity and exercise, such as the lack of knowledge and lack of tailored information, little access to exercise specialists, fatigue, and mobility challenges. Digitally delivered programmes have the potential to address several of these barriers, with techniques like “computer-tailoring” available to enable the delivery of tailored content at a time and place that is convenient. However, evaluation of such programmes is needed prior to implementation. This protocol describes a single group study that will examine the feasibility and acceptability of an online tool (ExerciseGuide UK) that provides those living with and beyond lung cancer web-based computer-tailored physical activity prescription and modules underpinned by behaviour change theories. Methods: Thirty-five individuals diagnosed with lung cancer, or cancer affecting the lung (e.g. pleural mesothelioma), will be recruited into a single-intervention arm. The platform will provide tailored resources and a personalised physical activity programme using IF-THEN algorithms. Exercise prescription will be tailored on factors such as self-reported specific pain location, exercise history, and current physical fitness. In addition, modules grounded in behaviour change will supplement the physical activity programme and will focus on topics such as exercise benefits, safety, goal setting, and tracking. The primary outcome will be assessed using pre-established criteria on feasibility and mixed-methods approach for acceptability. Secondary outcomes will explore changes in the physical activity, quality of life, anxiety, and depression. Discussion: This manuscript describes the protocol for a study examining the feasibility and acceptability of a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer. The publication of this protocol aims to increase the transparency of the methods, report pre-determined criteria, and aid replication of the study and associated materials. If feasible and acceptable, this intervention will inform future studies of digital-based interventions. Trail registration: ClinicalTrails.gov, NCT05121259. Registered on November 16, 2021

Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer?

Shear wave elastography (SWE) shows promise as an adjunct to greyscale ultrasound examination in assessing breast masses. In breast cancer, higher lesion stiffness on SWE has been shown to be associated with features of poor prognosis. The purpose of this study was to assess whether lesion stiffness at SWE is an independent predictor of lymph node involvement. Patients with invasive breast cancer treated by primary surgery, who had undergone SWE examination were eligible. Data were retrospectively analysed from 396 consecutive patients. The mean stiffness values were obtained using the Aixplorer(®) ultrasound machine from SuperSonic Imagine Ltd. Measurements were taken from a region of interest positioned over the stiffest part of the abnormality. The average of the mean stiffness value obtained from each of two orthogonal image planes was used for analysis. Associations between lymph node involvement and mean lesion stiffness, invasive cancer size, histologic grade, tumour type, ER expression, HER-2 status and vascular invasion were assessed using univariate and multivariate logistic regression. At univariate analysis, invasive size, histologic grade, HER-2 status, vascular invasion, tumour type and mean stiffness were significantly associated with nodal involvement. Nodal involvement rates ranged from 7 % for tumours with mean stiffness <50 kPa to 41 % for tumours with a mean stiffness of >150 kPa. At multivariate analysis, invasive size, tumour type, vascular invasion, and mean stiffness maintained independent significance. Mean stiffness at SWE is an independent predictor of lymph node metastasis and thus can confer prognostic information additional to that provided by conventional preoperative tumour assessment and staging

A Theoretical Review of Rotating Detonation Engines

Rotating detonation engines are a novel device for generating thrust from combustion, in a highly efficient, yet mechanically simple form. This chapter presents a detailed literature review of rotating detonation engines. Particular focus is placed on the theoretical aspects and the fundamental operating principles of these engines. The review covers both experimental and computational studies, in order to identify gaps in current understanding. This will allow the identification of future work that is required to further develop rotating detonation engines

Octonionic representations of Clifford algebras and triality

The theory of representations of Clifford algebras is extended to employ the division algebra of the octonions or Cayley numbers. In particular, questions that arise from the non-associativity and non-commutativity of this division algebra are answered. Octonionic representations for Clifford algebras lead to a notion of octonionic spinors and are used to give octonionic representations of the respective orthogonal groups. Finally, the triality automorphisms are shown to exhibit a manifest \perm_3 \times SO(8) structure in this framework.Comment: 33 page

Creative Product Problem-solving Game

Creativity is a talent that undergirds invention and innovation, making it an important skill in today’s society. Although students are often told to “be creative,” they many times do not know how and have little practice in this skill. This document presents an analysis of 33 creative products made by adult participants at a state conference for educators working with preK-12 gifted students or their teachers as a model for what teachers can do in their classrooms to allow students to practice creative thinking. During the conference presentation, Torrance’s creative strengths were reviewed with photographic examples, definitions, and suggestions printed on handouts. For the problem-solving game, each participant was given an identical set of recycled/craft materials, and about 30 minutes to create an object or scene fitting with a given theme. This presentation was delivered each of the two days of the conference with a different theme each day: “under water” was the theme the first day and “cool space” was the theme for the products on the second day. Participants each created an object that exhibited creative strengths and followed game-rules using the additional tools of scissors, glue, markers, and thread. Photographs of the final products are shown with their creative strengths identified. Most participants were successful in developing products that showed five creative strengths as required by the game rules. The most common approach to making a creative product that exhibited creative strengths was to tell an original story involving some motion that was detailed, artistically appealing, or humorous, and contained characters with emotional expressions. Because of the success and enthusiasm of participants for the game, the authors recommend it for students, clubs, and recreational activities. [7 Tables, 33 Figures, 6 References