Multidimensional scaling reveals a color dimension unique to 'color-deficient' observers

Normal color vision depends on the relative rates at which photons are absorbed in three types of retinal cone:short-wave (S), middle-wave (M) and long-wave (L) cones, maximally sensitive near 430, 530 and 560nm, respectively. But 6% of men exhibit an X-linked variant form of color vision called deuteranomaly [1]. Their color vision is thought to depend on S cones and two forms of long-wave cone (L, L′) [2,3]. The two types of L cone contain photopigments that are maximally sensitive near 560nm, but their spectral sensitivities are different enough that the ratio of their activations gives a useful chromatic signal

Relationship of global assessment of change to AUSCAN and pinch and grip strength among individuals with hand osteoarthritis

SummaryObjectiveThis study assessed the utility and construct validity of a new patient global assessment of symptom change for hand osteoarthritis (OA) by examining its associations with change over time in grip strength, pinch strength, and AUStralian CANadian Osteoarthritis Hand Index (AUSCAN).MethodsParticipants (N=531, 80% female, mean age=68) were part of a study on the Genetics of Generalized Osteoarthritis (GOGO) and completed two assessments (average 4 years apart). At the second assessment, participants described change in their right and left hand pain, aching, and stiffness on a 15-point scale with descriptors ranging from “Great deal worse” to “Great deal better”. Linear regression models examined associations of global change scores with changes in hand strength and AUSCAN, controlling for age, gender, number of hand joints with OA, and time between assessments.ResultsBoth right and left hand global assessment of change scores were significantly associated with change in AUSCAN, grip strength, and right hand pinch strength (P<0.05), and approached significance for left hand pinch strength (P=0.06). The strongest associations were between global change scores and AUSCAN change (right hand: β=0.29, P<0.001; left hand: β=0.27, P<0.001). Associations of change scores with grip and pinch strength were stronger among participants with greater radiographic OA severity at baseline.ConclusionResults support the validity of this new global assessment of symptom change. This measure is particularly useful for assessing change over time when no baseline data are available. Additional research should examine this measure's responsiveness in the context of clinical trials

Multi Agent Systems in Logistics: A Literature and State-of-the-art Review

Based on a literature survey, we aim to answer our main question: “How should we plan and execute logistics in supply chains that aim to meet today’s requirements, and how can we support such planning and execution using IT?” Today’s requirements in supply chains include inter-organizational collaboration and more responsive and tailored supply to meet specific demand. Enterprise systems fall short in meeting these requirements The focus of planning and execution systems should move towards an inter-enterprise and event-driven mode. Inter-organizational systems may support planning going from supporting information exchange and henceforth enable synchronized planning within the organizations towards the capability to do network planning based on available information throughout the network. We provide a framework for planning systems, constituting a rich landscape of possible configurations, where the centralized and fully decentralized approaches are two extremes. We define and discuss agent based systems and in particular multi agent systems (MAS). We emphasize the issue of the role of MAS coordination architectures, and then explain that transportation is, next to production, an important domain in which MAS can and actually are applied. However, implementation is not widespread and some implementation issues are explored. In this manner, we conclude that planning problems in transportation have characteristics that comply with the specific capabilities of agent systems. In particular, these systems are capable to deal with inter-organizational and event-driven planning settings, hence meeting today’s requirements in supply chain planning and execution

TransverseDiff gravity is to scalar-tensor as unimodular gravity is to General Relativity

Transverse Diffeomorphism (TDiff) theories are well-motivated theories of gravity from the quantum perspective, which are based upon a gauge symmetry principle. The main contribution of this work is to firmly establish a correspondence between TransverseDiff and the better-known scalar-tensor gravity --- in its more general form ---, a relation which is completely analogous to that between unimodular gravity and General Relativity. We then comment on observational aspects of TDiff. In connection with this proof, we derive a very general rule that determines under what conditions the procedure of fixing a gauge symmetry can be equivalently applied before the variational principle leading to the equations of motion, as opposed to the standard procedure, which takes place afterwards; this rule applies to gauge-fixing terms without derivatives.Comment: 10 pages; amsart style; v3: version as appeared in JCAP, redaction improve

Relationship of limb length inequality with radiographic knee and hip osteoarthritis

SummaryObjectiveThis study examined the relationship of limb length inequality (LLI) with radiographic hip and knee osteoarthritis (OA) in a large, community-based sample.MethodsThe total study group comprised 926 participants with radiographic knee OA, 796 with radiographic hip OA, and 210 (6.6%) with LLI ≥2cm. The presence of radiographic OA was defined as Kellgren/Lawrence (K/L) grade ≥2. Multiple logistic regression models were used to examine the relationship of LLI with hip and knee OA, while controlling for age, gender, race, body mass index, and history of hip or knee problems (joint injury, fracture, surgery, or congenital anomalies).ResultsIn unadjusted analyses, participants with LLI were more likely than those without LLI to have radiographic knee OA (45.1% vs 28.3%, P<0.001) and radiographic hip OA (35.2% vs 28.7%, P=0.063). In multiple logistic regression models, knee OA was significantly associated with presence of LLI (adjusted Odds Ratio [aOR]=1.80, 95% Confidence Interval [95% CI] 1.29–2.52), but there was no significant relationship between hip OA and LLI (aOR=1.20, 95% CI 0.86–1.67). Among participants with LLI, right hip OA was more common when the contralateral limb was longer than when the ipsilateral limb was longer (30.3% vs 17.5%, P=0.070).ConclusionLLI was associated with radiographic knee OA, controlling for other important variables. Future research should examine the relationship of LLI with hip or knee OA incidence, progression, and symptom severity, as well as the efficacy for LLI corrective treatments in OA