3,723 research outputs found
Understanding Perceptions of Problematic Facebook Use: When People Experience Negative Life Impact and a Lack of Control
While many people use social network sites to connect with friends and
family, some feel that their use is problematic, seriously affecting their
sleep, work, or life. Pairing a survey of 20,000 Facebook users measuring
perceptions of problematic use with behavioral and demographic data, we
examined Facebook activities associated with problematic use as well as the
kinds of people most likely to experience it. People who feel their use is
problematic are more likely to be younger, male, and going through a major life
event such as a breakup. They spend more time on the platform, particularly at
night, and spend proportionally more time looking at profiles and less time
browsing their News Feeds. They also message their friends more frequently.
While they are more likely to respond to notifications, they are also more
likely to deactivate their accounts, perhaps in an effort to better manage
their time. Further, they are more likely to have seen content about social
media or phone addiction. Notably, people reporting problematic use rate the
site as more valuable to them, highlighting the complex relationship between
technology use and well-being. A better understanding of problematic Facebook
use can inform the design of context-appropriate and supportive tools to help
people become more in control.Comment: CHI 201
Undoing a weak quantum measurement of a solid-state qubit
We propose an experiment which demonstrates the undoing of a weak continuous
measurement of a solid-state qubit, so that any unknown initial state is fully
restored. The undoing procedure has only a finite probability of success
because of the non-unitary nature of quantum measurement, though it is
accompanied by a clear experimental indication of whether or not the undoing
has been successful. The probability of success decreases with increasing
strength of the measurement, reaching zero for a traditional projective
measurement. Measurement undoing (``quantum un-demolition'') may be interpreted
as a kind of a quantum eraser, in which the information obtained from the first
measurement is erased by the second measurement, which is an essential part of
the undoing procedure. The experiment can be realized using quantum dot
(charge) or superconducting (phase) qubits.Comment: 5 page
Detection limits of organic compounds achievable with intense, short-pulse lasers
Many organic molecules have strong absorption bands which can be accessed by ultraviolet short pulse lasers to produce efficient ionization. This resonant multiphoton ionization scheme has already been exploited as an ionization source in time-of-flight mass spectrometers used for environmental trace analysis. In the present work we quantify the ultimate potential of this technique by measuring absolute ion yields produced from the interaction of 267 nm femtosecond laser pulses with the organic molecules indole and toluene, and gases Xe, N2 and O2. Using multiphoton ionization cross sections extracted from these results, we show that the laser pulse parameters required for real-time detection of aromatic molecules at concentrations of one part per trillion in air and a limit of detection of a few attomoles are achievable with presently available commercial laser systems. The potential applications for the analysis of human breath, blood and tissue samples are discussed
Uncollapsing the wavefunction by undoing quantum measurements
We review and expand on recent advances in theory and experiments concerning
the problem of wavefunction uncollapse: Given an unknown state that has been
disturbed by a generalized measurement, restore the state to its initial
configuration. We describe how this is probabilistically possible with a
subsequent measurement that involves erasing the information extracted about
the state in the first measurement. The general theory of abstract measurements
is discussed, focusing on quantum information aspects of the problem, in
addition to investigating a variety of specific physical situations and
explicit measurement strategies. Several systems are considered in detail: the
quantum double dot charge qubit measured by a quantum point contact (with and
without Hamiltonian dynamics), the superconducting phase qubit monitored by a
SQUID detector, and an arbitrary number of entangled charge qubits.
Furthermore, uncollapse strategies for the quantum dot electron spin qubit, and
the optical polarization qubit are also reviewed. For each of these systems the
physics of the continuous measurement process, the strategy required to ideally
uncollapse the wavefunction, as well as the statistical features associated
with the measurement is discussed. We also summarize the recent experimental
realization of two of these systems, the phase qubit and the polarization
qubit.Comment: 19 pages, 4 figure
Ninja data analysis with a detection pipeline based on the Hilbert-Huang Transform
The Ninja data analysis challenge allowed the study of the sensitivity of
data analysis pipelines to binary black hole numerical relativity waveforms in
simulated Gaussian noise at the design level of the LIGO observatory and the
VIRGO observatory. We analyzed NINJA data with a pipeline based on the Hilbert
Huang Transform, utilizing a detection stage and a characterization stage:
detection is performed by triggering on excess instantaneous power,
characterization is performed by displaying the kernel density enhanced (KD)
time-frequency trace of the signal. Using the simulated data based on the two
LIGO detectors, we were able to detect 77 signals out of 126 above SNR 5 in
coincidence, with 43 missed events characterized by signal to noise ratio SNR
less than 10. Characterization of the detected signals revealed the merger part
of the waveform in high time and frequency resolution, free from time-frequency
uncertainty. We estimated the timelag of the signals between the detectors
based on the optimal overlap of the individual KD time-frequency maps, yielding
estimates accurate within a fraction of a millisecond for half of the events. A
coherent addition of the data sets according to the estimated timelag
eventually was used in a characterization of the event.Comment: Accepted for publication in CQG, special issue NRDA proceedings 200
A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2.
BACKGROUND: Variation in an individual\u27s genetic status can impact the development of pancreatic ductal adenocarcinoma; however, the majority of familial pancreatic cancers (FPC) cannot yet be attributed to a specific inherited mutation. We present data suggesting a correlation between loss-of-function single nucleotide polymorphisms (SNPs) in an immune regulator gene, indoleamine-2,3-dioxygenase-2 (IDO2), and an increased risk of FPC.
STUDY DESIGN: Germline DNA from patients who underwent resection for pancreatic ductal adenocarcinoma (n = 79) was sequenced for the IDO2 SNPs R248W and Y359Stop. Genotypes resulting in inactivation of IDO2 (Y325X homozygous, R248W homozygous) were labeled as homozygous, and the other genotypes were grouped as wild-type or heterozygous. Genotype distributions of each SNP were analyzed for Hardy-Weinberg deviation. A genotype frequency set from the 1000 Genomes Project (n = 99) was used as a genetic control for genotype distribution comparisons.
RESULTS: A significant 2-fold increase in the overall prevalence of the Y359Stop homozygous genotype compared with the expected Hardy-Weinberg equilibrium was noted (p \u3c 0.05). Familial pancreatic cancer was noted in 15 cases (19%) and comparison of the FPC cohort set to the genetic control set showed a 3-fold increase in Y359Stop homozygous rates (p = 0.054). Overall in our cohort, the homozygous genotype group was associated with increased risk of FPC (odds ratio 5.4; 95% CI 1.6 to 17.6; p \u3c 0.01). Sex, age at diagnosis, and history of tobacco use were not found to be significantly associated with FPC.
CONCLUSIONS: Our preliminary data suggest a strong association between the IDO2 inactivating Y359Stop SNP and an increased risk of FPC when compared with the control group. Future studies will evaluate the value of IDO2 genotyping as a prognostic, early detection marker for pancreatic ductal adenocarcinoma and a predictive marker for novel immune checkpoint therapies
Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA.
Many intracellular bacteria, including Chlamydia, establish a parasitic membrane-bound organelle inside the host cell that is essential for the bacteria\u27s survival. Chlamydia trachomatis forms inclusions that are decorated with poorly characterized membrane proteins known as Incs. The prototypical Inc, called IncA, enhances Chlamydia pathogenicity by promoting the homotypic fusion of inclusions and shares structural and functional similarity to eukaryotic SNAREs. Here, we present the atomic structure of the cytoplasmic domain of IncA, which reveals a non-canonical four-helix bundle. Structure-based mutagenesis, molecular dynamics simulation, and functional cellular assays identify an intramolecular clamp that is essential for IncA-mediated homotypic membrane fusion during infection
Quadriceps Tendon Repair Using Double-Row Suture Anchor Fixation
Quadriceps tendon ruptures compromise the knee extensor mechanism and cause an inability to ambulate and significant functional limitations. Therefore, the vast majority of quadriceps tendon ruptures are indicated for operative intervention to restore patient mobility and function. Although these injuries were traditionally repaired using a transosseous repair technique, recent literature has shown that suture anchor repair may offer biomechanical advantages. Additionally, research in other areas of orthopaedics has found that a double-row suture anchor construct can offer additional biomechanical strength to tendinous repair. This technical note describes a safe and effective quadriceps tendon repair using a double-row suture anchor construct
Stereotype threat and test performance: A primer for school psychologists
Abstract Ethical guidelines require school psychologists to ensure that their assessment practices are nondiscriminatory, but typical discussions on this topic neglect the possible discriminatory effects of cultural stereotypes on assessment results. Recent research on stereotype threat shows that students' knowledge of stereotype-based negative expectations about their test performance can depress their actual test performance. This paper discusses the range of conditions that promote stereotype threat and identifies important moderators and mediators of the phenomenon. Several practical suggestions are offered for school psychologists to consider when interviewing students, interpreting assessment results, and developing programs to increase schoolwide achievement
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