Long-Term Safety and Effectiveness of Style 410 Highly Cohesive Silicone Breast Implants

In 2006, a single-center Swedish study demonstrated a low rupture rate and high patient satisfaction with the Style 410 shaped, form-stable gel implant. The current study aimed to validate the accuracy of the previously published results across multiple European sites.Journal ArticleMulticenter StudyResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe

The Heerlen confluence : porosity, integration and separation

Historically the river Rhine and the Meuse have acted not just as frontiers of separation between Germany to the east with Belgium and the Netherlands to the west, but over the centuries has also developed into a core-region of central Europe. The spatial, cultural and political landscape of where the Rhine and the Meuse merge forms a delta that is a melting pot of oral and architectural histories, cultures, people, and ways of life. Heerlen, located within this geography, experienced its heyday in the late nineteenth and twentieth century, at the peak of its mining past. The urban morphology of the city is reminiscent of a mining town facing inherent shrinkage, with attempts to challenge this phenomenon. Heerlen is currently facing serious socio-economic challenges, and to respond to these challenges the authors of this paper dissect the morphology of the city to discern the causes of its current predicaments, dynamism and its future potentials. By looking at the city and region as a mosaic of borders and languages, uniqueness of geography, industrial and mining activity, agriculture and people, the paper explores the inherent quality of place, and possibilities for active engagement of residents with their city. With economic developments being one of the key drivers of effective planning, the authors through this paper put forward planning and design ideas that can improve urban aesthetics and social cohesion of a shrinking city. The authors envision that shifts in traditional planning tools through small incremental changes such as urban agriculture and bottom-up initiatives of re-use are needed to examine the new realities and challenges facing the city of Heerlen, especially on issues of central city retail vacancy. This research acts as a platform where the authors approach the landscape surrounding Heerlen as a confluence of various structural, historic and cultural changes that are rooted in what we call as “porous lines of separation and integration”

Risk factors of incomplete apgar score and umbilical cord blood gas analysis: a retrospective observational study

Objective: To investigate whether incomplete umbilical cord blood gas (UCBG) analysis occurs more often than the incomplete reporting of the Apgar score, and risk factors associated with the incomplete values. Methods: A total of 8824 infants born alive after 26 weeks’ gestation between January 2009 and April 2013 were included. We extracted data on five-minute Apgar score, UCBG analysis, gestational age, mode of delivery, time of delivery and multiple pregnancy. Univariate and multivariable logistic regression analyses were performed. Results: Five-minute Apgar score was incomplete in 15 cases (0.2%) and UCBG analysis in 1960 cases (22.2%), p<0.05. Incomplete UCBG analysis was significantly more likely to occur in situations with Apgar score below seven (Odds ratio (OR) 1.68, 95% CI;1.29-2.19), gestational age between 26 to 27 6/7 and 28 to 31 6/7 weeks (OR 3.14, 95% CI; 2.13-4.62 and OR 1.91, 95% CI; 1.57-2.32), cesarean section (OR 1.31, 95% CI; 1.11-1.55), and multiple pregnancy (OR 2.02, 95% CI; 1.69-2.43). Deliveries during night time had a lower risk of incomplete UCBG analysis (OR 0.78, 95% CI; 0.69-0.88). Conclusions: Measuring five-minute Apgar score generated less incomplete data compared with UCBG analysis. The risk factors associated with incomplete UCBG analysis were noted. Study outcomes with UCBG analysis as neonatal assessment tool should be interpreted with caution

Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

MicroRNAs are 20- to 23-nucleotide RNA molecules that can regulate gene expression. Currently >400 microRNAs have been experimentally identified in mammalian genomes, whereas estimates go up to 1000 and beyond. Here we show that many more mammalian microRNAs exist. We discovered novel microRNA candidates using two approaches: testing of computationally predicted microRNAs by a modified microarray-based detection system, and cloning and sequencing of large numbers of small RNAs from different human and mouse tissues. Together these efforts experimentally identified 348 novel mouse and 81 novel human microRNA candidate genes. Most novel microRNAs candidates are not conserved beyond mammals, and ~10% are taxon-specific. Our analyses indicate that the entire microRNA repertoire is not remotely exhausted