Energy policies and risks on energy markets; a cost-benefit analysis

The key question dealt with in this report is whether and how governments should be involved in taking measures regarding security of energy supply. In order to answer this question, we developed a framework for cost-benefit analysis and applied this framework to a number of policy options. Read also the press release and accompanying�document ' Increasing the reliability of electricity production: a cost-benefit analysis '. The options chosen vary from government investments in strategic oil stocks to financial incentives for consumers to reduce their consumption of electricity. The set of options comprises several types of governmental action, including subsidies, regulation and government investments. Moreover, the selection includes measures meant to address risks on all three major energy markets: oil, natural gas, and electricity. The general picture following from the cases studied is that security of supply measures are hardly ever beneficial to welfare: benefits of policy measures do generally not outweigh costs. From an economic point of view, therefore, it would be often wiser to accept consequences of supply disruptions than to pursue security of supply at any cost. This implies that governments should exercise caution in imposing measures regarding security of supply. If serious market failure is detected, careful attention should be paid to the design of the corrective measure. Establishing and maintaining well-functioning markets appears to be an efficient approach in realising a secure supply of energy. That approach would include removal of entry barriers, securing equal access to essential facilities and increasing transparency of markets.

Improving clinical management in ANCA-associated vasculitis

In ANCA-associated small vessel vasculitis, patients may present with life threatening rapid clinical decline due to single or multiple organ involvement, especially targeting kidney and lungs (1). The sooner the diagnosis is made, the sooner appropriate and efficacious therapy can be installed. In an ideal situation, patient-tailored therapy should be available, optimizing the risk/benefit ratio of treatment, especially since the burden of toxicity of the induction and maintenance agents of choice can be huge. In this view, duration of maintenance therapy is also important and both choices of specific agents as well as the duration of treatment may have implications for the risks of morbidity, mortality and the quality of life. Following the initial treatment phase, there are several known risk factors for relapse and poor long term prognosis. In this thesis, we go into these factors to improve the clinical management and outcome of ANCA-associated vasculitis

The use of standard calendar software by individuals with acquired brain injury and cognitive complaints: a mixed methods study

PURPOSE: To explore the actual use of standard calendar software by people with acquired brain injury (ABI) and healthy individuals. METHOD: Mixed methods design with qualitative and quantitative analyses of the respondents' use of calendar software. Fifteen individuals with ABI and 15 healthy participants were enrolled. Participants were asked to execute five consecutive tasks using standard calendar software, which resembled everyday use of an electronic calendar. RESULTS: The core processes "task execution" and "information processing" were influenced by internal factors (cognitive and emotional processes and fatigue) as well as environmental factors (software features and distractions). Results obtained by qualitative and quantitative methods showed similar reaction patterns in both groups. However, ABI patients had more cognitive problems and showed stronger emotions during task performance than healthy participants. Healthy participants were more successful and needed less time and mental effort to perform a task. CONCLUSIONS: Although ABI patients were able to use standard calendar software, they became upset more easily, needed more effort, became tired sooner and more suddenly. Strategies to support ABI patients in the use of calendar software are suggested from multi-disciplinary perspectives

Project: A holistic analysis of the sustainability of banana and plantain production systems regarding pesticide exposure and its effect on neurodevelopment in early life

Spanish version available in IDRC Digital Library: Programa infantes y salud ambiental con un enfoque ecosistémico (ISA) : informe técnico final (abril 2009 - abril 2013); resumen ejecutivoThe program was created to assess and improve the sustainability of production systems of banana and plantain, using agroecological approaches to human health, particularly with regard to pesticide exposure and neurodevelopment of 0-2 years-old babies. In indigenous communities where plantains are being produced by smallholders, highly toxic pesticides are increasingly used. By analyzing impact of pesticides on children and with implementation of alternatives to pesticides, the project aims to improve pesticide awareness and health of people living in the ‘Huetar Atlántica’ region

Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

BACKGROUND: The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transplant patients. This study aims to analyze the effect of transplantation on aging of T and B cells in kidney transplant patients, with the emphasis on age and Cytomegalovirus (CMV) latency. RESULTS: We included 36 patients before and after (median 2.7 years) kidney transplantation and 27 age- and sex-matched healthy controls (HC). T and B cell subsets were measured by flow cytometry, with a focus on aged T cells (CD28-), and age associated B cells (ABCs, CD19 + CD21-CD11c+). Three years after transplantation a significant increase of total T cells among the lymphocytes was found compared to pre-transplantation and HC. Among the T cells CD4+ cells were decreased, especially naïve CD4+ cells and regulatory T cells. Total CD8+ cell proportions were increased, and proportions of naïve CD8+ cells were significantly decreased after transplantation, while CD8+ effector memory T cells re-expressing CD45RA were increased. CD28− T cells were significantly higher compared to HC after transplantation, especially in CMV seropositive patients. B cells were significantly decreased, while among B cells memory B cells and especially ABCs were increased after transplantation. CONCLUSIONS: After transplantation T and B cell subsets change towards more terminally differentiated memory cells compared to age-matched HC. Proportions of aged T cells and ABCs were associated with CMV serostatus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12979-021-00254-9