Age-related differences in renal side-effects of radiation and chemotherapy in the rat

The improved life-expectancy of cancer patient has brought to light late sequelae of oncology therapy. This is especially true for pediatric patients. Renal damage is one of the adverse side-effects of anti-tumor therapy that may occur. Studies conceming damaging effects of radiotherapy or chemotherapy on the kidney have generally been performed in adults. There is scant experimental or clinical information on renal function after anti -tumor therapy in the young. Rapid growth occurring in the developing kidney and age-dependent differences in phannacokinetics may influence. the extent of renal damage due to oncology therapy and may induce divergent effects in young or adult individuals. This thesis deals with experimental. results from studies in rats. A comparison was made between the effects of irradiation, chemotherapy, antibiotics, or a combination of these treatment modalities on the kidneys of either young and adult rats

Increased scalp hair cortisol concentrations in obese children

Context: Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. Objective: The aim of the study was to compare hair cortisol concentrations between obese and normal-weight c