663 research outputs found

    Proliferation of Hepatic Oval Cells via Cyclooxygenase-2 and Extracellular Matrix Protein Signaling during Liver Regeneration Following 2-AAF/Partial Hepatectomy in Rats

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    Analytical Model for the Structural Behavior of Pipelines During Lowering-In

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    Since pipelines experience the largest deformation during lowering-in, structural analysis for this construction sequence should be performed to ensure structural safety. In this study, a new analytical model named the “segmental pipeline model” was developed to predict the structural behavior of the pipeline. This analytical model consists of several segmental elements to represent various boundary and contact conditions. Therefore, the segmental pipeline model can consider the geometric configuration and characteristics of pipelines that appear during lowering-in. Adopting the Euler-Bernoulli beam and two-parameter beam on elastic foundation theory, the new model takes the effect of the soil and axial forces acting on the pipelines into account. This paper compares the displacements, sectional bending moments and shear forces of the pipeline obtained from the analytical model and finite element (FE) analysis, where good agreement was demonstrated. Also, the paper presents three examples to demonstrate the applicability of the analytical model

    Incorporation of Torsional & Higher-Mode Responses in Displacement-Based Seismic Design of Asymmetric RC Frame Buildings

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    Direct displacement-based design (DDBD) is currently a widely used displacement-based seismic design method. DDBD accounts for the torsional response of reinforced concrete (RC) frame buildings by using semi-empirical equations formulated for wall-type buildings. Higher-mode responses are incorporated by using equations obtained from only a few parametric studies of regular planar frames. In this paper, there is an attempt to eliminate torsional responses by proportioning frames’ secant stiffnesses so that the centers of rigidity and supported mass (the mass on and above each story) coincide. Once the torsional rotations are significantly reduced and only translational motions are achieved, higher-mode responses are included using a technique developed by the authors in their recent paper. The efficiency of the proposed design procedure in fulfilling the intended performance objective is checked by two plan-asymmetric 20-story RC frame building cases. Case-I has the same-plan configuration while Case-II has a different-plan configuration along the height. Both cases have different bay widths in orthogonal directions. Verification of the case studies by nonlinear time history analysis (NTHA) has shown that the proposed method results in designs that satisfy the performance objective with reasonable accuracy without redesigning members. It is believed that a step forward is undertaken toward rendering design verification by NTHA less necessary, thereby saving computational resources and effort

    Hydroelastic behaviour of pneumaticall oating structures in regular waves

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    Hydroelastic response of floating structures is of interest as they have various fields of applica ion including waterfront infrastructure, off-shore wind farms, LNG terminals, etc. This paper presents a numerical approach to examine the hydroelastic responses of the pneumatically supported floating structures for potential applications in floating jetties for LNG terminals. For the hydroelastic analysis, the fluid is modeled as a 2D semi-infinite strip of seawater whereas the floating structure is modeled as a beam. A direct coupled model is then constructed by using the boundary integral formulation for the fluid and FEM for the structure and by incorporating a pneumatic factor at the fluid-structure interface to consider the compressibility of air. For case studies of the pneumatic support effect, hydroelastic responses of the pneumatically supported type are compared to those of the pontoon type. It is shown that, in general, the pneumatic supports contribute to the reduction of the hydroelastic responses and the response reduction can be enhanced when some pneumatic support conditions are met
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