Fast and contrast-enhanced phase-sensitive magnetic resonance imaging

Phase-sensitive magnetic resonance (MR) imaging has a number of important clinical applications, such as phase-sensitive inversion recovery (PSIR) and Dixon water/fat imaging. PSIR and Dixon techniques are widely used in neurological and body imaging to improve tissue-contrast, the former by extending the dynamic range of image intensity and the later by suppressing unnecessary fat signals. Several important limitations, however, occur in these techniques: (1) Dixon techniques cannot decompose two signals if the resonance frequencies are close. For example, in MR mammography, it is difficult to separate silicone breast implants signals (4.0 ppm) from fat signals (3.5 ppm); (2) the signal dynamic range of images acquired using Dixon techniques is limited by the equilibrium magnetization; and (3) long image acquisition time. These limitations have hindered the applications of phase-sensitive Dixon imaging techniques on breast implant imaging or as a screening tool where fast acquisition is required. In this work, novel phase-sensitive MRI techniques were developed to enhance the capability, image-contrast, and scan-efficiency of Dixon imaging techniques. Specifically, we developed (1) a generalized chemical-shift imaging technique to separate spectrally overlapped signals both T1-contrast and chemical-shift; (2) a contrast-enhanced Dixon technique to extend the signal dynamic range of Dixon images; and (3) a single-echo acquisition (SEA) imaging technique integrated with phase-sensitive MR imaging to provide ultra-fast image acquisitions. Phantom studies, performed on 1.5 T and 4.7 T MR scanners, demonstrated the developed generalized chemical-shift imaging technique could clearly separate breast silicone implant signals (4.0 ppm) from fat (3.5 ppm). The contrast-enhanced Dixon technique, by extending the dynamic range of signal intensity from positive levels to positive/negative levels, could improve image-contrast by 1.6 times, compared with a conventional single-point Dixon technique. Phantom studies, using a 64-channel SEA imaging system, showed the integrated Dixon technique with SEA could acquire decomposed 2-D water-only and fat-only images with ultra-fast frame-rates up to 1/TR, while providing improved image-contrast (by 2.4 times in this experiment) compared with a conventional SEA imaging technique

Deep Learning for Automatic Detection and Segmentation from CT Angiography of Deep Inferior Epigastric Vascular Structures for Preoperative Planning of TRAM Flap Surgeries

https://openworks.mdanderson.org/sumexp23/1131/thumbnail.jp

Oscillatory spin-orbit torque switching induced by field-like torques

Deterministic magnetization switching using spin-orbit torque (SOT) has recently emerged as an efficient means to electrically control the magnetic state of ultrathin magnets. The SOT switching still lacks in oscillatory switching characteristics over time, therefore, it is limited to bipolar operation where a change in polarity of the applied current or field is required for bistable switching. The coherent rotation based oscillatory switching schemes cannot be applied to SOT because the SOT switching occurs through expansion of magnetic domains. Here, we experimentally achieve oscillatory switching in incoherent SOT process by controlling domain wall dynamics. We find that a large field-like component can dynamically influence the domain wall chirality which determines the direction of SOT switching. Consequently, under nanosecond current pulses, the magnetization switches alternatively between the two stable states. By utilizing this oscillatory switching behavior we demonstrate a unipolar deterministic SOT switching scheme by controlling the current pulse duration

Spontaneous Lead Breakage in Implanted Spinal Cord Stimulation Systems

Spinal cord stimulation (SCS) has become an established clinical option for treatment of refractory chronic pain. Current hardware and implantation techniques for SCS are already highly developed and continuously improving; however, equipment failures over the course of long-term treatment are still encountered in a relatively high proportion of the cases treated with it. Percutaneous SCS leads seem to be particularly prone to dislocation and insulation failures. We describe our experience of lead breakage in the inserted spinal cord stimulator to a complex regional pain syndrome patient who obtained satisfactory pain relief after the revision of SCS

Renal outcomes of laparoscopic versus open surgery in patients with rectal cancer: a propensity score analysis

Background A laparoscopic approach is widely used in abdominal surgery. Although several studies have compared surgical and oncological outcomes between laparoscopic surgery (LS) and open surgery (OS) in rectal cancer patients, there have been few studies on postoperative renal outcomes. Methods We conducted a retrospective cohort study involving 1,633 patients who underwent rectal cancer surgery between 2003 and 2017. Postoperative acute kidney injury (AKI) was diagnosed according to the serum creatinine criteria of the Kidney Disease: Improving Global Outcomes classification. Results Among the 1,633 patients, 1,072 (65.6%) underwent LS. After matching propensity scores, 395 patients were included in each group. The incidence of postoperative AKI in the LS group was significantly lower than in the OS group (9.9% vs. 15.9%; p = 0.01). Operation time, estimated blood loss, and incidence of transfusion in the LS group were significantly lower than those in the OS group. Cox proportional hazard models revealed that LS was associated with decreased risk of postoperative AKI (hazard ratio [HR], 0.599; 95% confidence interval [CI], 0.402–0.893; p = 0.01) and postoperative transfusion was associated with increased risk of AKI (HR, 2.495; 95% CI, 1.529–4.072; p < 0.001). In the subgroup analysis, the incidence of postoperative AKI in patients with middle or high rectal cancer who underwent LS was much lower than in those who underwent OS (HR, 0.373; 95% CI, 0.197–0.705; p = 0.002). Conclusion This study showed that LS may have a favorable effect on the development of postoperative AKI in patients with rectal cancer

Childhood Acute Lymphoblastic Leukemia Showing Unilateral Motor Dysfunction Prior to Chemotherapy: A Diffusion Tensor Tractography Study

This study aimed to evaluate children with lymphoblastic leukemia and examine the potential correlation between corticospinal tract (CST) injury and motor dysfunction prior to chemotherapy using diffusion tensor tractography (DTT). Nineteen consecutive patients with childhood leukemia (mean age 7.483 ± 3.1 years, range 4–12 years) with unilateral motor dysfunction who underwent DTT prior to chemotherapy and twenty healthy individuals (mean age 7.478 ± 1.2 years; range 4–12 years) were enrolled. Motor functions were evaluated by two independent investigators. The cause of neurological dysfunction was identified based on the CST state using mean fractional anisotropy (FA), mean fiber volume (FV), and CST integrity using DTT. All patients showed disrupted integrity and significantly decreased FA and FV in the affected CST compared to the unaffected CST and the control group (p < 0.05). These DTT results also corresponded to patients’ unilateral motor dysfunction. Using DTT, we demonstrated that neurological dysfunction may occur in patients with childhood acute lymphoblastic leukemia even prior to chemotherapy, and that CST injuries correlate with motor dysfunction in these patients. DTT may be a useful modality for evaluating the neural tract state in pediatric leukemia patients with neurological dysfunction

Study of a Betavoltaic Battery Using Electroplated Nickel-63 on Nickel Foil as a Power Source

A betavoltaic battery was prepared using radioactive 63Ni attached to a three-dimensional single trenched P–N absorber. The optimum thickness of a 63Ni layer was determined to be approximately 2 μm, considering the minimum self-shielding effect of beta particles. Electroplating of radioactive 63Ni on a nickel (Ni) foil was carried out at a current density of 20 mA/cm2. The difference of the short-circuit currents (Isc) between the pre- and postdeposition of 63Ni (16.65 MBq) on the P–N junction was 5.03 nA, as obtained from the I–V characteristics. An improved design with a sandwich structure was provided for enhancing performance