Early life nutrition and gastrointestinal and allergic outcomes: the Generation R Study

This thesis particularly focused on the outcomes of constipation, celiac disease auto antibodies, asthma-like symptoms, and atopic dermatitis, which are all prevalent in the general population. In line with this, the main goals of this thesis were to assess: · Infant nutrition: o Consequences of timing of complementary feeding o Determinants of dietary patterns in toddlers · Gastrointestinal outcomes: o Consequences of celiac disease autoantibodies during pregnancy o Nutritional and endocrinological determinants of functional constipation in childhood · Asthma-like symptoms and atopic dermatitis: o Nutritional determinants of asthma-like symptoms and atopic de

Implicit Measures in Clinical Sex Research:A Critical Evaluation

INTRODUCTION: Current information-processing models of sexual arousal imply that both controlled and automatic affective-motivational processes are critically involved in sexual responding and suggest that dysfunctional automatic processes may be involved in the development and persistence of sexual dysfunctions. Because (dysfunctional) automatic processes and responses cannot be adequately captured by common self-report measures, implicit performance-based measures have been developed to index these processes. OBJECTIVES: This review provides an overview of studies that used implicit tasks in clinical sexual research, and critically evaluates the contribution and promise of these measures to improve our understanding of the mechanisms involved in sexual dysfunctions. METHODS: 6 electronic main databases (AMED, MEDLINE, PsycArticles, Psychology & Behavioral Sciences Collection, PsycINFO, and SocINDEX) were searched for studies involving implicit measurement techniques to measure automatic processes in clinical sex research. RESULTS: A series of studies examined if lowered (or heightened) attention for sex stimuli may be involved in low sexual arousal, low desire, and genital pain. Preliminary evidence showed that lowered attention is involved in low sexual arousal. The pattern with regard to desire and genital pain was mixed which may be due to heterogeneity in assessment instruments. A limited number of studies examined automatic memory associations with sexual cues. Preliminary evidence showed negative (sex-threat/sex-disgust) associations in women with genito-pelvic pain or penetration disorder, less positive associations in women with hypoactive sexual desire disorder, and sex-positive and sex-failure associations in men with sexual distress. Thus far, no studies have examined lowered (or heightened) automatic sexual approach tendencies related to sexual dysfunctions. CONCLUSION: Implicit measures showed some promise as tools to index automatic sex-relevant cognitive mechanisms in sexual dysfunctions. Yet, more systematic research and the development of psychometrically sound measures are critical for a more comprehensive evaluation of the relevance of implicit measures in clinical sex research and their usefulness as indices of individual differences in clinical practice. Hinzmann J, Borg C, de Jong PJ. Implicit Measures in Clinical Sex Research: A Critical Evaluation. Sex Med Rev 2020;8:531-541

Disgust Toward Sex-Relevant and Sex-Irrelevant Stimuli in Pre-, Early, and Middle Adolescence

For prepubertal youth, sexual stimuli elicit disgust and avoidance, yet in adolescence this avoidance shifts to sexual approach. One explanation could be that disgust declines in adolescence. This project examined whether disgust is indeed lower in adolescence compared to preadolescence, and whether this difference across age groups would be restricted to sex-relevant disgust elicitors. We also examined whether the strength of disgust would depend on familiarity between participant and source. To examine disgust responses in youths, two cross-sectional studies (N = 248, ages six to 17 years) were conducted using scenario-based measurements. Disgust was overall higher in early adolescence than in preadolescence and relatively weak when the source of disgust was a familiar person. Specifically, when parents were the source, sex-relevant disgust was higher in the groups of early and middle adolescents than in the group of preadolescents. Sex-relevant disgust elicited by a stranger or best friend, however, was lower in middle than in early adolescence. The latter is consistent with the view that repeated confrontation with disgusting stimuli might attenuate disgust, which could contribute to healthy sexual functioning. The heightened sex-relevant disgust in middle adolescents when parents were the source might reflect a functional avoidance mechanism of inappropriate sex mates

Ancient Cities and Landscapes in the Kurdistan Region of Iraq: The Erbil Plain Archaeological Survey 2012 Season

In 2012, the Erbil Plain Archaeological Survey (EPAS) conducted its first season of fieldwork. The project’s goal is the complete mapping of the archaeological landscape of Erbil, with an emphasis on the Neo-Assyrian and Hellenistic periods. It will test the hypothesis that the Neo-Assyrian landscape was closely planned. This first report emphasizes the project’s field methodology, especially the use of a variety of satellite remote sensing imagery. Our preliminary results suggest that the plain was part of the urbanized world of Mesopotamia, with new cities of the Bronze Age, Iron Age, and Sasanian era identified.Anthropolog

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity

The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild. Lifespan in birds is known to be positively correlated with body size and negatively correlated with metabolic rate, though the genetic mechanisms for the red-crowned crane's long lifespan have not previously been investigated. Using whole genome sequencing and comparative evolutionary analyses against the grey-crowned crane and other avian genomes, including the long-lived common ostrich, we identified red-crowned crane candidate genes with known associations with longevity. Among these are positively selected genes in metabolism and immunity pathways (NDUFA5, NDUFA8, NUDT12, SOD3, CTH, RPA1, PHAX, HNMT, HS2ST1, PPCDC, PSTK CD8B, GP9, IL-9R, and PTPRC). Our analyses provide genetic evidence for low metabolic rate and longevity, accompanied by possible convergent adaptation signatures among distantly related large and long-lived birds. Finally, we identified low genetic diversity in the red-crowned crane, consistent with its listing as an endangered species, and this genome should provide a useful genetic resource for future conservation studies of this rare and iconic species

Analysis of trace metals (Cu, Cd, Pb, and Fe) in seawater using single batch nitrilotriacetate resin extraction and isotope dilution inductively coupled plasma mass spectrometry

A simple and accurate low-blank method has been developed for the analysis of total dissolved copper, cadmium, lead, and iron in a small volume (1.3–1.5 mL per element) of seawater. Pre-concentration and salt-separation of a stable isotope spiked sample are achieved by single batch extraction onto nitrilotriacetate (NTA)-type Superflow® chelating resin beads (100–2400 beads depending on the element). Metals are released into 0.1–0.5 M HNO[subscript 3], and trace metal isotope ratios are determined by ICPMS. The benefit of this method compared to our previous Mg(OH)2 coprecipitation method is that the final matrix is very dilute so cone-clogging and matrix sensitivity suppression are minimal, while still retaining the high accuracy of the isotope dilution technique. Recovery efficiencies are sensitive to sample pH, number of resin beads added, and the length of time allowed for sample–resin binding and elution; these factors are optimized for each element to yield the highest recovery. The method has a low procedural blank and high sensitivity sufficient for the analysis of pM–nM open-ocean trace metal concentrations. Application of this method to samples from the Bermuda Atlantic Time-Series Study station provides oceanographically consistent Cu, Cd, Pb, and Fe profiles that are in good agreement with other reliable data for this site. In addition, the method can potentially be modified for the simultaneous analysis of multiple elements, which will be beneficial for the analysis of large number of samples.National Science Foundation (U.S.) (NSF frant OCE-0751409)Kuwait Foundation for the Advancement of SciencesNational Science Foundation (U.S.) (NSF award OCE-0751409)National Science Foundation (U.S.) (NSF award OCE-0926197