Mrub_2120, Mrub_2121, Mrub_2122, Mrub_2123 and Mrub_2124 are orthologs of \u3cem\u3eE. coli\u3c/em\u3e genes b3458, b3457, b3456, b3455 and b3454, respectively, and make up an operon that codes for the branched-chain amino acid ABC transporter in \u3cem\u3eMeiothermus ruber\u3c/em\u3e DSM 1279

In this project we investigated the biological function of the genes Mrub_2120, Mrub_2121, Mrub_2122, Mrub_2123 and Mrub_2124 (KEGG map number 02010). We predict these genes encode components of a branched-chain amino acid ATP Binding Cassette (ABC) transporter: 1) Mrub_2120 (DNA coordinates 2169247-2170416 on the reverse strand) encodes the branched-chain amino acid binding protein that is localized to the periplasm; 2) Mrub_2121 (DNA coordinates 2170433..2171353 on the reverse strand) encodes the first TMD; 3) Mrub_2122 (DNA coordinates 2171365..2172279 on the reverse strand) encodes the second TMD; 4) Mrub_2123 (DNA coordinates 2172276..2173028 on the reverse strand) encodes the first NBD; 5) Mrub_2124 (DNA coordinates 2173025…2173735 on the reverse strand) encodes the second NBD. This branched-chain amino acid transport system has been found in E. coli K-12 MG1655 which was used as the model organism in this study. The predicted homologs of Mrub_2120, Mrub_2121, Mrub_2122, Mrub_2123 and Mrub_2124, are livK, livH, livM, livG and livF, respectively. Together, these genes form an operon encoding for an ABC transporter that selectively transports branched-chain amino acids across the intracellular plasma membrane of bacteria. This project is part of the Meiothermus ruber genome analysis project, which predicts gene function using the bioinformatics tools collected under the umbrella of the Guiding Education through Novel Investigation–Annotation Collaboration Toolkit (GENI-ACT)

Draft Genome Sequencing of Three Glutaraldehyde-Tolerant Bacteria from Produced Water from Hydraulic Fracturing

Here, we report the draft genome sequence of three glutaraldehyde-resistant isolates from produced water from hydraulic fracturing operations. The three strains were identified as sp. strain G11, sp. strain G15, and sp. strain G16. The genome sequences of these isolates will provide insights into biocide resistance in hydraulic fracturing operations

Getting Genetic Ancestry Right for Science and Society

There is a scientific and ethical imperative to embrace a multidimensional, continuous view of ancestry and move away from continental ancestry categorie

A public health approach to understanding and preventing violent radicalization

<p>Abstract</p> <p>Background</p> <p>Very recent acts of terrorism in the UK were perpetrated by 'homegrown', well educated young people, rather than by foreign Islamist groups; consequently, a process of violent radicalization was proposed to explain how ordinary people were recruited and persuaded to sacrifice their lives.</p> <p>Discussion</p> <p>Counterterrorism approaches grounded in the criminal justice system have not prevented violent radicalization. Indeed there is some evidence that these approaches may have encouraged membership of radical groups by not recognizing Muslim communities as allies, citizens, victims of terrorism, and victims of discrimination, but only as suspect communities who were then further alienated. Informed by public health research and practice, a new approach is proposed to target populations vulnerable to recruitment, rather than rely only on research of well known terrorist groups and individual perpetrators of terrorist acts.</p> <p>Conclusions</p> <p>This paper proposes public health research and practice to guard against violent radicalization.</p

2018 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1005/thumbnail.jp

Quantifying heterodonty in the Late Devonian (Upper Famennian) sharks Cladoselache and Ctenacanthus from the Ohio Shale, USA

Differentiation of tooth size and shape within the jaw (i.e. heterodonty) is an expected pattern in the majority of Neoselachii sharks. Various forms of heterodonty may be observed within an individual set of jaws, which can be the result of tooth position (monognathic), upper or lower jaw position (dignathic), tooth file or developmental position (ontogeny), or between male and female in sex specific differences (gynandric). Heterodonty patterns result from natural selection as a functional linkage tied to feeding niche for both feeding performance and dietary diversity. However, the types and/or degree of heterodonty present in Devonian sharks such as Cladoselache and Ctenacanthus have not previously been discussed or quantified in the literature. The objective of this study was to analyze a number of associated dentitions from representatives of these two genera, all collected from the Cleveland Shale Member of the Ohio Shale (upper Famennian; Upper Devonian), to test for, and quantify, various types of heterodonty within and across taxonomic lineages of early cladodont sharks. Geometric morphometrics and linear measurements were used to describe tooth shape and resulting axes and measurements were regressed with jaw position, tooth file position, and upper versus lower jaw to test for differentiation associated with various types of heterodonty. Teeth from Cladoselache and Ctenacanthus dentitions that were examined did not show any variation in tooth shape consistent with heterodonty. However, tooth size did vary slightly with jaw position and the presence of symphyseal teeth at the lower jaw symphysis does indicate differentiation between upper and lower jaws. Furthermore, the long period of tooth retention characteristic of these genera create a record of ontogenetic heterodonty within a tooth file observable as an increase in tooth size lingually. Although tooth shape did not significantly co-vary with jaw position in either taxa, significant morphometric differences between the two genera were evident. These findings strengthen the taxonomic validity of the genera and recognized species within these genera and provide further insights into the niche of these Devonian sharks

Quantifying heterodonty in the Late Devonian (Upper Famennian) sharks Cladoselache and Ctenacanthus from the Ohio Shale, USA

Differentiation of tooth size and shape within the jaw (i.e. heterodonty) is an expected pattern in the majority of Neoselachii sharks. Various forms of heterodonty may be observed within an individual set of jaws, which can be the result of tooth position (monognathic), upper or lower jaw position (dignathic), tooth file or developmental position (ontogeny), or between male and female in sex specific differences (gynandric). Heterodonty patterns result from natural selection as a functional linkage tied to feeding niche for both feeding performance and dietary diversity. However, the types and/or degree of heterodonty present in Devonian sharks such as Cladoselache and Ctenacanthus have not previously been discussed or quantified in the literature. The objective of this study was to analyze a number of associated dentitions from representatives of these two genera, all collected from the Cleveland Shale Member of the Ohio Shale (upper Famennian; Upper Devonian), to test for, and quantify, various types of heterodonty within and across taxonomic lineages of early cladodont sharks. Geometric morphometrics and linear measurements were used to describe tooth shape and resulting axes and measurements were regressed with jaw position, tooth file position, and upper versus lower jaw to test for differentiation associated with various types of heterodonty. Teeth from Cladoselache and Ctenacanthus dentitions that were examined did not show any variation in tooth shape consistent with heterodonty. However, tooth size did vary slightly with jaw position and the presence of symphyseal teeth at the lower jaw symphysis does indicate differentiation between upper and lower jaws. Furthermore, the long period of tooth retention characteristic of these genera create a record of ontogenetic heterodonty within a tooth file observable as an increase in tooth size lingually. Although tooth shape did not significantly co-vary with jaw position in either taxa, significant morphometric differences between the two genera were evident. These findings strengthen the taxonomic validity of the genera and recognized species within these genera and provide further insights into the niche of these Devonian sharks