The Unheard Voices and Privilege of a Killer: An Analysis of \u3cem\u3eConversations with a Killer: The Ted Bundy Tapes\u3c/em\u3e

This analysis of Conversations with a Killer explores representations of Bundy’s victims and the depiction of Bundy himself. This paper will focus on how the documentary is an example of white male privilege and gender inequality through its erasure of the victims’ identities and perpetuation of a celebrity-like narrative of Bundy

Light-emitting diode street lights reduce last-ditch evasive manoeuvres by moths to bat echolocation calls

© 2015 The Authors. The light-emitting diode (LED) street light market is expanding globally, and it is important to understand how LED lights affect wildlife populations. We compared evasive flight responses of moths to bat echolocation calls experimentally under LED-lit and -unlit conditions. Significantly, fewer moths performed ‘powerdive’ flight manoeuvres in response to bat calls (feeding buzz sequences from Nyctalus spp.) under an LED street light than in the dark. LED street lights reduce the anti-predator behaviour of moths, shifting the balance in favour of their predators, aerial hawking bats

Physical activity levels of Reception children in the North-East of England: a cross-sectional analysis of seasonal, daily and hourly variation.

Children’s early years are a key time for development, with research suggesting that engaging in physical activity (PA) can have positive health effects. The aim of this study was to describe the cross-sectional PA levels, PA guideline compliance, and how PA varies according to temporal, demographic, and anthropometric factors in Reception children in the North-East of England. Accelerometer measured PA data was recorded and processed according to time spent in sedentary behaviour (SB), light, moderate, moderate to vigorous PA (MVPA) and total PA and analyses were performed according to individual and environmental variations. 265 children provided valid PA data (defined as 8 hours of wear time on three days). 51% of the sample were boys. Children engaged in 261.6 minutes/day of SB, 99.5 minutes/day of MVPA and 271.6 minutes/day of light PA. Significant differences were observed according to season, day of the week, time of the day, sex, socioeconomic status, age, and body mass index-z (BMI-z). This study found that on average, 4–5-year-old children in the North-East of England met the UK PA guidelines. However, there were temporal, sex and socioeconomic differences in PA, highlighting opportunities to promote PA at schools and at home

Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance

Given the increase in resistance to antibacterial agents, there is an urgent need for the development of new agents with novel modes of action. As an interim solution, it is also prudent to reinvestigate old or abandoned antibacterial compounds to assess their efficacy in the context of widespread resistance to conventional agents. In the 1970s, much work was performed on the development of peptide mimetics, exemplified by the phosphonopeptide, alafosfalin. We investigated the activity of alafosfalin, di-alanyl fosfalin and β-chloro-L-alanyl-β-chloro-L-alanine against 297 bacterial isolates, including carbapenemase-producing Enterobacterales (CPE) (n = 128), methicillin-resistant Staphylococcus aureus (MRSA) (n = 37) and glycopeptide-resistant enterococci (GRE) (n = 43). The interaction of alafosfalin with meropenem was also examined against 20 isolates of CPE. The MIC50 and MIC90 of alafosfalin for CPE were 1 mg/L and 4 mg/L, respectively and alafosfalin acted synergistically when combined with meropenem against 16 of 20 isolates of CPE. Di-alanyl fosfalin showed potent activity against glycopeptide-resistant isolates of Enterococcus faecalis (MIC90; 0.5 mg/L) and Enterococcus faecium (MIC90; 2 mg/L). Alafosfalin was only moderately active against MRSA (MIC90; 8 mg/L), whereas β-chloro-L-alanyl-β-chloro-L-alanine was slightly more active (MIC90; 4 mg/L). This study shows that phosphonopeptides, including alafosfalin, may have a therapeutic role to play in an era of increasing antibacterial resistance

User-centered development of a Virtual Research Environment to support collaborative research events

This paper discusses the user-centred development process within the Collaborative Research Events on the Web (CREW) project, funded under the JISC Virtual Research Environments (VRE) programme. After presenting the project, its aims and the functionality of the CREW VRE, we focus on the user engagement approach, grounded in the method of co-realisation. We describe the different research settings and requirements of our three embedded user groups and the respective activities conducted so far. Finally we elaborate on the main challenges of our user engagement approach and end with the project’s next steps

ELF3 controls thermoresponsive growth in Arabidopsis

Plant development is highly responsive to ambient temperature, and this trait has been linked to the ability of plants to adapt to climate change [1]. The mechanisms by which natural populations modulate their thermoresponsiveness are not known [2]. To address this, we surveyed Arabidopsis accessions for variation in thermal responsiveness of elongation growth and mapped the corresponding loci. We find that the transcriptional regulator EARLY FLOWERING3 (ELF3) controls elongation growth in response to temperature. Through a combination of modeling and experiments, we show that high temperature relieves the gating of growth at night, highlighting the importance of temperature-dependent repressors of growth. ELF3 gating of transcriptional targets responds rapidly and reversibly to changes in temperature. We show that the binding of ELF3 to target promoters is temperature dependent, suggesting a mechanism where temperature directly controls ELF3 activity

London Schools Excellence Fund: Final Report: Enhancing the teaching of STEM through Design and Technology

London Schools Excellence Fund: Final Report: Enhancing the teaching of STEM through Design and Technolog

Happier during lockdown: a descriptive analysis of self-reported wellbeing in 17,000 UK school students during Covid-19 lockdown.

Funder: The Westminster FoundationRelatively little research has focused on children and young people (CYP) whose mental health and wellbeing improved during Covid-19 lockdown measures. We aimed to (1) determine the proportion of CYP who self-reported improvement in their mental wellbeing during the first Covid-19 lockdown and (2) describe the characteristics of this group in relation to their peers. We conducted a descriptive analysis of data from the 2020 OxWell Student Survey, a self-report, cross-sectional survey of English CYP. A total of 16,940 CYP primarily aged 8-18 years reported on change in mental wellbeing during lockdown. We characterised these CYP in terms of school, home, relational, and lifestyle factors as well as feelings about returning to school. One-third (33%) of CYP reported improved mental wellbeing during the first UK national lockdown. Compared with peers who reported no change or deterioration, a higher proportion of CYP with improved mental wellbeing reported improved relationships with friends and family, less loneliness and exclusion, reduced bullying, better management of school tasks, and more sleep and exercise during lockdown. In conclusion, a sizeable minority of CYP reported improved mental wellbeing during lockdown. Determining the reasons why these CYP felt they fared better during lockdown and considering how these beneficial experiences can be maintained beyond the pandemic might provide insights into how to promote the future mental health and wellbeing of school-aged CYP. All those working with CYP now have an opportunity to consider whether a systemic shift is needed in order to understand and realise any learnings from experiences during the pandemic.Funding ES is funded by a Gates Cambridge Scholarship (Grant Number: OPP1144). SP is funded by a National Institute for Health Research (NIHR) Post-Doctoral Fellowship award (Grant Number PDF-2017-10-029) and The Westminster Foundation. NC is supported by funding from the UK Research and Innovation (UKRI) Emerging Minds Network. KLM is funded by the NIHR Oxford Health Biomedical Research Centre (BRC-1215-20005). PBJ is supported by the NIHR Applied Research Collaboration East of England. MF was supported by funding from the NIHR Applied Research Collaboration Oxford and Thames Valley at Oxford Health NHS Foundation Trust. The OxWell Student Survey is supported by the NIHR Oxford Health Biomedical Research Centre, an MRC Pathfinder Award to the University of Oxford, and the Westminster Foundation. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care