Transcriptional territories in the genome

An analysis of numerous Drosophila microarray experiments reveals that the genome has many large groups of adjacent genes that are expressed similarly but are not functionally related

A marriage of techniques

Technical wizardry has made possible the combination of two powerful methodologies, optical trapping and single-molecule fluorescence, to measure precisely the force required to unzip DNA

RNAi and the shape of things to come

A large-scale screen in Drosophila cells has shown how RNA interference can provide insights into the pathways controlling cell morphology

Dishevelled nuclear shuttling

Structure-function analysis of the Dishevelled (Dsh) protein in frog embryos has defined sequences that regulate Dsh nuclear localization, which proves critical for Wnt signaling

Co-regulation of mouse genes predicts function

Large-scale microarray analyses reveal that transcriptional co-regulation patterns can be remarkably helpful in predicting the function of novel mouse genes

Imaging with isotopes: high resolution and quantitation

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Tracking evolution's footprints in the genome

The strategy of using 'phylogenetic footprinting' to find regulatory sites that are conserved between pairs of related complex genomes has led to the development of a suite of computational tools that succeed in finding functionally important transcription-factor-binding sequences

A road map of yeast interactions

Analysis of a yeast network that integrates five interaction datasets reveals the presence of large topological structures reflecting biological themes

Growing without a size checkpoint

Mammalian cells, unlike yeast, seem to maintain a constant distribution of cell sizes without a cell-size checkpoint