72 research outputs found
Several Roads Lead to Rome: Operationalizing Antibiotic Stewardship Programs in Nursing Homes
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153068/1/jgs16279_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153068/2/jgs16279.pd
Advancing Epidemiological Science Through Computational Modeling: A Review with Novel Examples
Computational models have been successfully applied to a wide variety of research areas including infectious disease epidemiology. Especially for questions that are difficult to examine in other ways, computational models have been used to extend the range of epidemiological issues that can be addressed, advance theoretical understanding of disease processes and help identify specific intervention strategies. We explore each of these contributions to epidemiology research through discussion and examples. We also describe in detail models for raccoon rabies and methicillin-resis-tant Staphylococcus aureus, drawn from our own research, to further illustrate the role of computation in epidemiological modeling
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Effectiveness of an Antimicrobial Polymer to Decrease Contamination of Environmental Surfaces in the Clinical Setting
We performed a real-world, controlled intervention to investigate
use of an antimicrobial surface polymer, MSDS Poly, on environmental
contamination. Pathogenic bacteria were identified in 18
(90%) of 20 observations in treated rooms and 19 (83%) of 23
observations in untreated rooms (P = .67). MSDS Poly had no
significant effect on environmental contamination.This is the publisher’s final pdf. The article is copyrighted by the Society for Healthcare Epidemiology of America and published by the University of Chicago Press. It can be found at: http://www.jstor.org/page/journal/infeconthospepid/about.html
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Healthcare-Associated Infection and Hospital Readmission
OBJECTIVE. Hospital readmissions are a current target of initiatives to reduce healthcare costs. This study quantified the association between having a clinical culture positive for 1 of 3 prevalent hospital-associated organisms and time to hospital readmission.
DESIGN. Retrospective cohort study.
PATIENTS AND SETTING. Adults admitted to an academic, tertiary care referral center from January 1, 2001, through December 31, 2008.
METHODS. The primary exposure of interest was a clinical culture positive for methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), or Clostridium difficile obtained more than 48 hours after hospital admission during the index hospital stay. The primary outcome of interest was time to readmission to the index facility. Multivariable Cox proportional hazards models were used to model the adjusted association between positive clinical culture result and time to readmission and to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS. Among 136,513 index admissions, the prevalence of hospital-associated positive clinical culture result for 1 of the 3 organisms of interest was 3%, and 35% of patients were readmitted to the index facility within 1 year after discharge. Patients with a positive clinical culture obtained more than 48 hours after hospital admission had an increased hazard of readmission (HR, 1.40; 95% CI, 1.33-1.46) after adjusting for age, sex, index admission length of stay, intensive care unit stay, Charlson comorbidity index, and year of hospital admission.
CONCLUSIONS. Patients with healthcare-associated infections may be at increased risk of hospital readmission. These findings may be used to impact health outcomes after discharge from the hospital and to encourage better infection prevention efforts. Infect Control Hosp Epidemiol 2012; 33(6): 539-544Keywords: Stay,
Therapy,
Length,
Resistant staphylococcus aureus,
Mortality,
Outcomes,
Impact,
Model,
Surveillance,
Risk factor
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Risk of Acquiring Extended-Spectrum β-Lactamase–Producing Klebsiella Species and Escherichia coli from Prior Room Occupants in the Intensive Care Unit
OBJECTIVE. To quantify the association between admission to an intensive care unit (ICU) room most recently occupied by a patient positive for extended-spectrum beta-lactamase (EBSL)-producing gram-negative bacteria and acquisition of infection or colonization with that pathogen.
DESIGN. Retrospective cohort study.
SETTING AND PATIENTS. The study included patients admitted to medical and surgical ICUs of an academic medical center between September 1, 2001, and June 30, 2009.
METHODS. Perianal surveillance cultures were obtained at admission to the ICU, weekly, and at discharge from the ICU. Patients were included if they had culture results that were negative for ESBL-producing gram-negative bacteria at ICU admission and had an ICU length of stay longer than 48 hours. Pulsed-field gel electrophoresis (PFGE) was performed on ESBL-positive isolates from patients who acquired the same bacterial species (eg, Klebsiella species or Escherichia coli) as the previous room occupant.
RESULTS. Among 9,371 eligible admissions (7,651 unique patients), 267 (3%) involved patients who acquired an ESBL-producing pathogen in the ICU; of these patients, 32 (12%) were hospitalized in a room in which the prior occupant had been positive for ESBL. Logistic regression results suggested that the prior occupant's ESBL status was not significantly associated with acquisition of an ESBL-producing pathogen (adjusted odds ratio, 1.39 [95% confidence interval, 0.94-2.08]) after adjusting for colonization pressure and antibiotic exposure in the ICU. PFGE results suggested that 6 (18%) of 32 patients acquired a bacterial strain that was the same as or closely related to the strain obtained from the prior occupant.
CONCLUSIONS. These data suggest that environmental contamination may not play a substantial role in the transmission of ESBL-producing pathogens among ICU patients. Intensifying environmental decontamination may be less effective than other interventions in preventing transmission of ESBL-producing pathogens. Infect Control Hosp Epidemiol 2013;34(5):453-458Keywords: Enterobacteriaceae, Colonization pressure, Vancomycin resistant enterococci, Infection, Staphylococcus aureus, To patient transmission, Comorbidity index, Pneumoniae, Acquisition, Bacteri
Staphylococcus aureus Infections in US Veterans, Maryland, USA, 1999–20081
Trends in Staphylococcus aureus infections are not well described. To calculate incidence in overall S. aureus infection and invasive and noninvasive infections according to methicillin susceptibility and location, we conducted a 10-year population-based retrospective cohort study (1999–2008) using patient-level data in the Veterans Affairs Maryland Health Care System. We found 3,674 S. aureus infections: 2,816 (77%) were noninvasive; 2,256 (61%) were methicillin-resistant S. aureus (MRSA); 2,517 (69%) were community onset, and 1,157 (31%) were hospital onset. Sixty-one percent of noninvasive infections were skin and soft tissue infections; 1,112 (65%) of these were MRSA. Ten-year averaged incidence per 100,000 veterans was 749 (± 132 SD, range 549–954) overall, 178 (± 41 SD, range 114–259) invasive, and 571 (± 152 SD, range 364–801) noninvasive S. aureus infections. Incidence of all S. aureus infections significantly increased (p<0.001), driven by noninvasive, MRSA, and community-onset infections (p<0.001); incidence of invasive S. aureus infection significantly decreased (p<0.001)
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Antimicrobial Use for Symptom Management in Patients Receiving Hospice and Palliative Care: A Systematic Review
BACKGROUND: Patients receiving hospice or palliative care often receive antimicrobial therapy; however the effectiveness
of antimicrobial therapy for symptom management in these patients is unknown.
OBJECTIVE: The study’s objective was to systematically review and summarize existing data on the prevalence and
effectiveness of antimicrobial therapy to improve symptom burden among hospice or palliative care patients.
DESIGN: Systematic review of articles on microbial use in hospice and palliative care patients published from
January 1, 2001 through June 30, 2011.
MEASUREMENTS: We extracted data on patients’ underlying chronic condition and health care setting, study
design, prevalence of antimicrobial use, whether symptom response following antimicrobial use was measured,
and the method for measuring symptom response.
RESULTS: Eleven studies met our inclusion criteria in which prevalence of antimicrobial use ranged from 4% to 84%.
Eight studies measured symptom response following antimicrobial therapy. Methods of symptom assessment
were highly variable and ranged from clinical assessment from patients’ charts to the Edmonton Symptom
Assessment Scale. Symptom improvement varied by indication, and patients with urinary tract infections (two
studies) appeared to experience the greatest improvement following antimicrobial therapy (range 67% to 92%).
CONCLUSION: Limited data are available on the use of antimicrobial therapy for symptom management among
patients receiving palliative or hospice care. Future studies should systematically measure symptom response
and control for important confounders to provide useful data to guide antimicrobial use in this population
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Frequency of Outpatient Antibiotic Prescription on Discharge to Hospice Care
The use of antibiotics is common in hospice care despite limited evidence that it improves symptoms or quality of life. Patients
receiving antibiotics upon discharge from a hospital may be more likely to continue use following transition to hospice care despite
a shift in the goals of care. We quantified the frequency and characteristics for receiving a prescription for antibiotics on
discharge from acute care to hospice care. This was a cross-sectional study among adult inpatients (≥18 years old) discharged to
hospice care from Oregon Health & Science University (OHSU) from 1 January 2010 to 31 December 2012. Data were collected
from an electronic data repository and from the Department of Care Management. Among 62,792 discharges, 845 (1.3%) patients
were discharged directly to hospice care (60.0% home and 40.0% inpatient). Most patients discharged to hospice were >65
years old (50.9%) and male (54.6%) and had stayed in the hospital for ≤7 days (56.6%). The prevalence of antibiotic prescription
upon discharge to hospice was 21.1%. Among patients discharged with an antibiotic prescription, 70.8% had a documented infection
during their index admission. Among documented infections, 40.3% were bloodstream infections, septicemia, or endocarditis,
and 38.9% were pneumonia. Independent risk factors for receiving an antibiotic prescription were documented infection
during the index admission (adjusted odds ratio [AOR]=7.00; 95% confidence interval [95% CI]=4.68 to 10.46),
discharge to home hospice care (AOR=2.86; 95% CI=1.92 to 4.28), and having a cancer diagnosis (AOR=2.19; 95% CI=1.48
to 3.23). These data suggest that a high proportion of patients discharged from acute care to hospice care receive an antibiotic
prescription upon discharge
Community-associated Methicillin-resistant Staphylococcus aureus Bacteremia and Endocarditis among HIV Patients: A cohort study
<p>Abstract</p> <p>Background</p> <p>HIV patients are at increased risk of development of infections and infection-associated poor health outcomes. We aimed to 1) assess the prevalence of USA300 community-associated methicillin-resistant <it>Staphylococcus aureus </it>(CA-MRSA) among HIV-infected patients with <it>S. aureus </it>bloodstream infections and. 2) determine risk factors for infective endocarditis and in-hospital mortality among patients in this population.</p> <p>Methods</p> <p>All adult HIV-infected patients with documented <it>S. aureus </it>bacteremia admitted to the University of Maryland Medical Center between January 1, 2003 and December 31, 2005 were included. CA-MRSA was defined as a USA300 MRSA isolate with the MBQBLO spa-type motif and positive for both the arginine catabolic mobile element and Panton-Valentin Leukocidin. Risk factors for <it>S. aureus</it>-associated infective endocarditis and mortality were determined using logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI). Potential risk factors included demographic variables, comorbid illnesses, and intravenous drug use.</p> <p>Results</p> <p>Among 131 episodes of <it>S. aureus </it>bacteremia, 85 (66%) were MRSA of which 47 (54%) were CA-MRSA. Sixty-three patients (48%) developed endocarditis and 10 patients (8%) died in the hospital on the index admission Patients with CA-MRSA were significantly more likely to develop endocarditis (OR = 2.73, 95% CI = 1.30, 5.71). No other variables including comorbid conditions, current receipt of antiretroviral therapy, pre-culture severity of illness, or CD4 count were significantly associated with endocarditis and none were associated with in-hospital mortality.</p> <p>Conclusions</p> <p>CA-MRSA was significantly associated with an increased incidence of endocarditis in this cohort of HIV patients with MRSA bacteremia. In populations such as these, in which the prevalence of intravenous drug use and probability of endocarditis are both high, efforts must be made for early detection, which may improve treatment outcomes.</p
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