Deformation-phase measurement of diffuse objects that have started nonrepeatable dynamic deformation

金沢大学理工研究域機械工学系We have developed what we believe is a new technique for obtaining a whole-field image representing the deforming amounts of a diffuse object. The object is supposedly continuously deforming and does not stop deforming during the measurement. This technique uses arccosine operations to extract the absolute, not signed, value of the phase. We assume that a right-phase change retains almost the same value in a small local area. This retention determines the sign of the phase and consequently the value of the phase change. The deformation phase during any term of the deforming process is shown as a map through the temporal-phase unwrapping of the calculated phase. © 2001 Optical Society of America

Cell microfactories: manufacturing cell-based therapeutics [TCES abstract]

Cell microfactories: manufacturing cell-based therapeutics [TCES abstract

Cell microfactories: manufacturing cell-based therapeutics [FIRM abstract]

Cell microfactories: manufacturing cell-based therapeutics [FIRM abstract

A meta-analysis of biological variation in blood-based therapy as a precursor to bio-manufacturing

This paper was accepted for publication in the journal Cytotherapy and the definitive published version is available at http://dx.doi.org/10.1016/j.jcyt.2016.01.011Currently cellular therapies, such as hematopoietic stem cell transplantation (HSCT), are produced at a small scale on a case-by-case basis, usually in a clinical or near-clinical setting. Meeting the demand for future cellular therapies will require a robust and scalable manufacturing process that is either designed around or controls the variation associated with biological starting materials. Understanding variation requires both a measure of the allowable variation (that does not negatively affect patient outcome) and the achievable variation (with current technology). The prevalence of HSCT makes it an ideal case study to prepare for more complex biological manufacturing with more challenging regulatory classifications. A systematic meta-analysis of the medical literature surrounding HSCT has been completed of which the key outcomes are the following: (i) the range of transplanted CD34+ cells/kg can be up to six orders of magnitude around the median for allogeneic procedures and four orders of magnitude for autologous procedures, (ii) there is no improvement in variation encountered over a period of 30 years and (iii) as study size increases, the amount of variation encountered also increases. A more detailed, stratified source from a controlled single-site clinical center is required to further define a control strategy for the manufacture of biologics

Nonperturbing measurements of spatially distributed underwater acoustic fields using a scanning laser Doppler vibrometer

This article was published in the journal, Journal of the Acoustical Society of America [© Acoustical Society of America] and is also available at: http://asa.aip.org/jasa.htmlLocalized changes in the density of water induced by the presence of an acoustic field cause perturbations in the localized refractive index. This relationship has given rise to a number of nonperturbing optical metrology techniques for recording measurement parameters from underwater acoustic fields. A method that has been recently developed involves the use of a Laser Doppler Vibrometer (LDV) targeted at a fixed, nonvibrating, plate through an underwater acoustic field. Measurements of the rate of change of optical pathlength along a line section enable the identification of the temporal and frequency characteristics of the acoustic wave front. This approach has been extended through the use of a scanning LDV, which facilitates the measurement of a range of spatially distributed parameters. A mathematical model is presented that relates the distribution of pressure amplitude and phase in a planar wave front with the rate of change of optical pathlength measured by the LDV along a specifically orientated laser line section. Measurements of a 1 MHz acoustic tone burst generated by a focused transducer are described and the results presented. Graphical depictions of the acoustic power and phase distribution recorded by the LDV are shown, together with images representing time history during the acoustic wave propagation