Effect of pharmacological treatment on cardiac biomarkers in patients with acute coronary syndrome of non–ST segment elevation with Type-2 diabetes

The acute coronary syndrome is a consequence of coronary artery disease. Creatine Kinase MB is a cardiac biochemical marker used in the diagnosis and risk stratification of patients. The diabetes is a pathology associated to acute coronary syndrome non–ST segment elevation that change the cardiac conditions, in this sense, our objective was to evaluate the modifications of cardiac biomarkers values in diabetic patients. Materials and methods: A retrospective study included 155 patients of both sexes, ages ranging from 31 to 92 years old, admitted to the coronary unit of the “Reina Fabiola†Clinic, Córdoba, Argentina was performed in the period 2014-2015. Body mass index, time consultation pain, plasmatic Creatine Kinase isoenzyme MB activity and Troponin I levels were measured. The patients were stratified into two groups: without cardiovascular risk pathologies (Control group), n = 7; and with only type II diabetes, n = 64 treated with therapeutic doses of metformin (n= 37), and glibenclamide plus glizipide (n= 27). Results: cTnI levels were lower in both pharmacological treatments at 12 hrs when the values in control reach the highest. Similarly, CK-MB activity was lower at 8 hrs in both treatments; however at 12 hrs these values were lower only with metformin but not in glibenclamide plus glizipide treatment. These results could be showing an interaction between diabetes and pharmacological treatment upon the biomarkers values. Conclusion: The use of hypoglycemic drugs and the glycometabolic state are conditions that could modify CK-MB and cTnI release/clearance balance at 8 and 12 hrs after admission to the coronary unit.Fil: Joison, Agustín Néstor. Universidad Catolica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentin

Study of pH and fluoride levels in salivary and dental plaque in children with temporal, mixed and permanent teeth

INTRODUCCIÓN: Las caries es la enfermedad oral que mayor destrucción causa a los tejidos dentales, se da gracias a la conjugación de varios factores, uno de ellos es la alteración de pH salival. En los niños, el pH desempeña un importante papel en la remineralización del esmalte dental. La concentración de fluoruro en el esmalte y zona pulpar de la dentina es relativamente alta. Él fluoruro juega un papel muy importante, inclinando el proceso hacia la remineralización y desarrollo de una estructura dental más resistente al ataque de los ácidos.OBJETIVO: La presente investigación tiene como objetivo estudiar los valores del pH y flúor salival y paca biofilm dental relacionado a los diferentes tipos de dentición.POBLACIÓN Y MÉTODO: Se estudiaron 28 pacientes de ambos sexos y edades entre 3 a 12 años que concurrieron a la clínica odontológica de la Universidad Católica de Córdoba. Estudio aleatorio, descriptivo y transversal. Se analizó pH, capacidad buffer, niveles de flúor. La dentición fue clasificada como temporaria, permanente y mixta.RESULTADOS: Se observó mayor cantidad de flúor en placa dental, alta lactancia materna, buena capacidad buffer, con niveles elevados de bicarbonato. Se encontró correlación positiva entre los niveles de flúor en placa dental y pH salival (r: 0.40, p < 0.05). En análisis de varianza (ANOVA II) encontró diferencias significativas en los niveles de flúor en saliva respecto a placa dental en el sexo masculino 0.013 ± 0.002 vs 0.047 ± 0.016; p < 0.05.CONCLUSIÓN: El análisis de las muestras mostró correlación positiva entre pH y flúor en saliva.INTRODUCTION: Caries oral disease occurring further destruction cause to dental tissues, by combination of several factors as modification of salivary pH and fluoride levels in salivary and dental plaque. In children pH and fluorideplays an important role in the mineralization of dental enamel. The concentration of fluoride in the enamel and dentin pulp area is relatively high. Fluoride plays a very important role, by tilting the process towards development of a dental structure more resistant to attack by acids and remineralization. OBJECTIVES: The objective of this research are to study the values of pH and fluoride in salivaryrespect to different dentition. METHODS AND POPULATION: 28 patients of both sexes and ages 3 to 12 years who were attended in the dental clinic of Córdoba Catholic University. Design: Randomized, descriptive, cross-sectional study. Variables analyzed were samples of saliva and dental plaque pH and fluoride. The dentition was classified as temporary, permanent and mixed. RESULTS: The study showed high amount of fluoride in dental plaque good buffer capacity, with high levels of bicarbonate was observed. Positive correlation was founded between the levels of fluoride in dental plaque and salivary pH was found (r: 0.40, p < 0.05). The analysis of variance (ANOVA II) showed significant differences in the fluoride levelsin saliva respect to dental plaque in male 0.013 ± 0.002 vs 0.047 ± 0.016; p < 0.05; levels of fluoride in dental plaque in females regard males 0.017 ± 0.003 vs 0.047 ± 0.016p < 0.05. CONCLUSION: The analysis of samples of saliva and dental plaque of the patients studied, showedFil: Joison, Agustín Néstor. Universidad Católica de Córdoba; ArgentinaFil: Gargantini, Pablo Ruben. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Modification of cardiac biomarkers sensity in hypertensive patiens treated with angiotensin-converting enzyme inhibitors in acute coronary syndrome with non-st segment elevation

Background: Patients with non-ST segment elevation myocardial infarction and the mortality risk is associated when Creatine Kinase isoenzyme MB and Troponin I values are increase. Objective: The present study was oriented to study the modification of cTnI and CK-MB sensitivity in the arterial hypertension and its association with drugs in the antihypertensive treatment. Methods: A descriptive and random study included 35 hypertensive patients of both sexes, admitted to the coronary unit of the “Reina Fabiola “Clinic”. The patients were stratified without associated pathologies (Control group), n = 13; and with only hypertension, n = 22 treated with angiotensin-converting enzyme inhibitors (n= 15), beta-blockers (n = 7). Samples of blood were collected and cardiac markers analyzed at the entrance to the coronary care unit (0 hs) and after 8, 12, 24 hs. Results: Creatine Kinase MB activity decreased at 8 hs and Troponin I sensibility showed a decrease in hypertensive patients treated with angiotensin-converting enzyme inhibitors respect control group at 0 hs. Optimal cut points of CK-MB were 13.50, 17.00, 19.50 and 14.00 UI/L, and to cTnI 0.08, 0.17, 0.16 and 0.42 ng/ml at 0, 8, 12, and 24 hs respectively. Conclusions: The remodeling and ventricular hypertrophy states are conditions that could be modify biomarkers levels and sensitivity by the use of antihypertensive drugs. We propose an algorithm incorporating changes in cTnI levels and CK-MB activity to increases the diagnostic sensitivity in AHT patients.Fil: Joison, Agustín Néstor. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Barcudi, Raúl J.. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; ArgentinaFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentin