‘A Sense of Region’? Independent Television in the Midlands, 1950 - 2000

This project has been undertaken with the intention of discussing two closely related themes, the first of which is to provide a general history of ITV's performance in the Midlands in the twentieth century, in which the most significant events to have occurred during this period have been analysed, and various assessments on these events have emerged as a result. The second, and most important, of these themes, concerns the concept of `regional identity', leading to the question of the extent to which the companies that have represented TTV in the Midlands since the mid-1950s (ATV, ABC, Central, and Carlton) have attempted to create or reflect feelings of regionalism in general, and regional identity in particular, through their programmes and other activities. The information included in this study has come from a variety of sources, including reports and other relevant material from the companies themselves, and from the various broadcasting authorities, whose responsibility has been to administer the work of the companies. In addition, this project contains extracts from a series of interviews with some of the most important people connected with ITV in the Midlands, including presenters, producers, and senior executives from the various companies, and other interested parties, including representatives from the broadcasting authorities. This study concludes with an examination of Carlton's record in the Midlands following its takeover of Central in 1994, and considers the future prospects for ITV in the Midlands under Carlton or any other company that assumes control of the broadcasting licence for the commercial channel in this region

Additional file 3: Figure S2. of A biologically informed method for detecting rare variant associations

Wilcoxon type I error per biological feature. QQ plots for the type I error Wilcoxon Rank Sum analysis showing the p-value distribution from the average gene (a), XL gene (b), and pathway (c) simulations. The different colors represent various BioBin weighting schemes analyzed. (PNG 147 kb

Additional file 1: of A biologically informed method for detecting rare variant associations

Script for generating reference sequence. Python script used to generate a reference sequence file for input into SeqSIMLA2 simulation software. The allele frequency file used in the script was obtained by parsing the protein coding regions of the autosomes in the 1000 Genomes Project VCF file. Additional specifications include the number of reference samples to generate and the number of markers to include in the reference file. (DOCX 14 kb

Additional file 2: Figure S1. of A biologically informed method for detecting rare variant associations

Logistic regression type I error per biological feature. QQ plots for the type I error logistic regression analysis showing the p-value distribution from the average gene (a), XL gene (b), and pathway (c) simulations. The different colors represent various BioBin weighting schemes analyzed. (PNG 170 kb

Image_1_Petrale sole transboundary connectivity and settlement success: a biophysical approach.jpeg

Connectivity between inferred spawning areas and potential settlement areas of the petrale sole (Eopsetta jordani) was explored in the California Current System (CCS) using an individual-based model (IBM) coupled with the ROMS hydrodynamic model for the period 1988-2008. The IBM modeled pelagic early life stages, including egg and larval development, growth, natural mortality and settlement into benthos. Eggs were released within discrete spawning grounds identified from the winter fishery logbook data. Potential settlement areas were defined based on bathymetrical criteria and juvenile (2-year old) distribution from a groundfish bottom trawl survey. The influence of cross-shelf and alongshore advection on the transport and connectivity between spawning and benthic settlement areas was explored by identifying the location of juveniles (22 mm length) among the potential settlement areas. The most important spawning regions varied over time with between 4 and 19% of spawned individuals successfully settling, mostly ranging from off northern Washington to northern Oregon. The strong influence of northward alongshore transport resulted in transboundary transport of pelagic life stages from U.S. spawning grounds to inner shelf settlement areas in Canadian waters, with 33.9-70.4% (average 49.7 ± 9.6) of annual successful juveniles settling in Canada. Interannual variability in juvenile settlement success suggests that mesoscale (100-200 km) oceanographic structures play a major role defining pelagic juvenile transport trajectories. While, in some years, the presence of coastal cyclonic eddies can retain juveniles off Oregon, the strong northward transport supplies a large number of juveniles to Moresby and Vancouver island, clearly showing that petrale sole off the west coast of North America are a transboundary stock with important settlement areas off the coast of British Columbia, thus extension of this study into Canadian waters is particularly relevant.</p

Image_2_Petrale sole transboundary connectivity and settlement success: a biophysical approach.jpeg

Connectivity between inferred spawning areas and potential settlement areas of the petrale sole (Eopsetta jordani) was explored in the California Current System (CCS) using an individual-based model (IBM) coupled with the ROMS hydrodynamic model for the period 1988-2008. The IBM modeled pelagic early life stages, including egg and larval development, growth, natural mortality and settlement into benthos. Eggs were released within discrete spawning grounds identified from the winter fishery logbook data. Potential settlement areas were defined based on bathymetrical criteria and juvenile (2-year old) distribution from a groundfish bottom trawl survey. The influence of cross-shelf and alongshore advection on the transport and connectivity between spawning and benthic settlement areas was explored by identifying the location of juveniles (22 mm length) among the potential settlement areas. The most important spawning regions varied over time with between 4 and 19% of spawned individuals successfully settling, mostly ranging from off northern Washington to northern Oregon. The strong influence of northward alongshore transport resulted in transboundary transport of pelagic life stages from U.S. spawning grounds to inner shelf settlement areas in Canadian waters, with 33.9-70.4% (average 49.7 ± 9.6) of annual successful juveniles settling in Canada. Interannual variability in juvenile settlement success suggests that mesoscale (100-200 km) oceanographic structures play a major role defining pelagic juvenile transport trajectories. While, in some years, the presence of coastal cyclonic eddies can retain juveniles off Oregon, the strong northward transport supplies a large number of juveniles to Moresby and Vancouver island, clearly showing that petrale sole off the west coast of North America are a transboundary stock with important settlement areas off the coast of British Columbia, thus extension of this study into Canadian waters is particularly relevant.</p

Additional file 3: Table S3. of Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial

Individual histopathological scores and H. pylori status before and after treatment for each volunteer. (DOCX 15 kb

Additional file 1: Table S1. of Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial

Gastrointestinal symptoms occurrence in the previous 7 days as reported by each volunteer before the initiation and at the end of treatments. (DOCX 17 kb

Additional file 3: Table S3. of Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial

Individual histopathological scores and H. pylori status before and after treatment for each volunteer. (DOCX 15 kb

Leave one out cross validation for regression of diversification against latitude.

Points and error bars represent estimates of the coefficient of this regression (±2 SE) with the corresponding fleet removed from the data, red line indicates the mean estimate of the coefficient with all fleets included in the analysis. Changes in sign of the coefficient indicate a difference in the qualitative directional relationship between diversification and latitude. (TIFF)</p