A Fresh Look at Axions and SN 1987A

We re-examine the very stringent limits on the axion mass based on the strength and duration of the neutrino signal from SN 1987A, in the light of new measurements of the axial-vector coupling strength of nucleons, possible suppression of axion emission due to many-body effects, and additional emission processes involving pions. The suppression of axion emission due to nucleon spin fluctuations induced by many-body effects degrades previous limits by a factor of about 2. Emission processes involving thermal pions can strengthen the limits by a factor of 3-4 within a perturbative treatment that neglects saturation of nucleon spin fluctuations. Inclusion of saturation effects, however, tends to make the limits less dependent on pion abundances. The resulting axion mass limit also depends on the precise couplings of the axion and ranges from 0.5x10**(-3) eV to 6x10**(-3) eV.Comment: 32 latex pages, 13 postscript figures included, uses revtex.sty, submitted to Physical Review

Cattle Handling Facilities: Planning, Components, and Layouts

Cattle handling facilities are used to confine cattle safely and efficiently for close observation and to perform routine health and management procedures. Adequate facilities are an essential part of an efficient cattle operation for any producer who wants to improve marketing, cattle health, and production. A well-planned handling facility can help you save money by making easier practices such as preventive health management, pregnancy testing, implanting, controlling parasites, vaccinating, castrating, and dehorning

A Gauge-invariant Analysis of Magnetic Fields in General Relativistic Cosmology

We provide a fully general-relativistic treatment of cosmological perturbations in a universe permeated by a large-scale primordial magnetic field, using the Ellis-Bruni gauge-invariant formalism. The exact non-linear equations for general relativistic magnetohydrodynamic evolution are derived. A number of applications are made: the behaviour of small perturbations to Friedmann universes are studied; a comparison is made with earlier Newtonian treatments of cosmological perturbations and some effects of inflationary expansion are examined.Comment: 31 pages, Latex, Submitted to Classical and Quantum Gravit

The SISO CSPI PDG standard for commercial off-the-shelf simulation package interoperability reference models

For many years discrete-event simulation has been used to analyze production and logistics problems in manufactur-ing and defense. Commercial-off-the-shelf Simulation Packages (CSPs), visual interactive modelling environ-ments such as Arena, Anylogic, Flexsim, Simul8, Witness, etc., support the development, experimentation and visua-lization of simulation models. There have been various attempts to create distributed simulations with these CSPs and their tools, some with the High Level Architecture (HLA). These are complex and it is quite difficult to assess how a set of models/CSP are actually interoperating. As the first in a series of standards aimed at standardizing how the HLA is used to support CSP distributed simula-tions, the Simulation Interoperability Standards Organiza-tion’s (SISO) CSP Interoperability Product Development Group (CSPI PDG) has developed and standardized a set of Interoperability Reference Models (IRM) that are in-tended to clearly identify the interoperability capabilities of CSP distributed simulations

From mindless masses to small groups: Conceptualizing collective behavior in crowd modeling.

Computer simulations are increasingly used to monitor and predict behavior at large crowd events, such as mass gatherings, festivals and evacuations. We critically examine the crowd modeling literature and call for future simulations of crowd behavior to be based more closely on findings from current social psychological research. A systematic review was conducted on the crowd modeling literature (N = 140 articles) to identify the assumptions about crowd behavior that modelers use in their simulations. Articles were coded according to the way in which crowd structure was modeled. It was found that 2 broad types are used: mass approaches and small group approaches. However, neither the mass nor the small group approaches can accurately simulate the large collective behavior that has been found in extensive empirical research on crowd events. We argue that to model crowd behavior realistically, simulations must use methods which allow crowd members to identify with each other, as suggested by self-categorization theory

Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging.

The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC analysis detailed herein is the comprehensive biological analysis of the tumor specificity of JAA-F11 antibody performed as JAA-F11 is progressing towards preclinical safety testing and clinical trials. Wide tumor reactivity of JAA-F11, relative to the matched mouse IgG3 (control), was observed in 85% of 1269 cases of breast, lung, prostate, colon, bladder, and ovarian cancer. Staining on tissues from breast cancer cases was similar regardless of hormonal or Her2 status, and this is particularly important in finding a target on the currently untargetable triple-negative breast cancer subtype. Humanization of JAA-F11 was recently carried out as explained in a companion paper "Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis" (Neoplasia 19: 716-733, 2017), and it was confirmed that humanization did not affect chemical specificity. IHC studies with humanized JAA-F11 showed similar binding to human breast tumor tissues. In vivo imaging and biodistribution studies in a mouse syngeneic breast cancer model and in a mouse-human xenograft lung cancer model with humanized 124I- JAA-F11 construct confirmed in vitro tumor reactivity and specificity. In conclusion, the tumor reactivity of JAA-F11 supports the continued development of JAA-F11 as a targeted cancer therapeutic for multiple cancers, including those with unmet need

The X-ray Reflectors in the Nucleus of the Seyfert Galaxy NGC 1068

(abridged) Based on observations of the Seyfert nucleus in NGC1068 with ASCA, RXTE and BeppoSAX, we report the discovery of a flare (increase in flux by a factor of ~1.6) in the 6.7 keV Fe K line component between observations obtained 4 months apart, with no significant change in the other (6.21, 6.4, and 6.97 keV) Fe K_alpha line components. During this time, the continuum flux decreased by ~20%. The RXTE spectrum requires an Fe K absorption edge near 8.6 keV (Fe XXIII - XXV). The spectral data indicate that the 2-10 keV continuum emission is dominated (~2/3 of the luminosity) by reflection from a previously unidentified region of warm, ionized gas located <~ 0.2 pc from the AGN. The remaining ~1/3 of the observed X-ray emission is reflected from optically thick, neutral gas. The inferred properties of the warm reflector (WR) are: size (diameter) ~ 10^{5.5} /cm3, ionization parameter xi approx 10^{3.5} erg cm/s, and covering fraction 0.003 (L_0/10^{43.5} erg/s)^{-1} < (Omega/4 pi) < 0.024 (L_0/10^{43.5})^{-1}, where L_0 is the intrinsic 2-10 keV X-ray luminosity of the AGN. We suggest that the WR gas is the source of the (variable) 6.7 keV Fe line emission, and the 6.97 keV Fe line emission. The 6.7 keV line flare is assumed to be due to an increase in the emissivity of the WR gas from a decrease (by 20-30%) in L_0. The properties of the WR are most consistent with an intrinsically X-ray weak AGN with L_0 approx 10^{43.0} erg/s. The optical and UV emission that scatters from the WR into our line of sight is required to suffer strong extinction, which can be reconciled if the line-of-sight skims the outer surface of the torus. Thermal bremsstrahlung radio emission from the WR may be detectable in VLBA radio maps of the NGC 1068 nucleus.Comment: 39 pages (9 postscript figures) AASTEX, ApJ, accepte

The HST Key Project on the Extragalactic Distance Scale XVII. The Cepheid Distance to NGC 4725

The distance to NGC 4725 has been derived from Cepheid variables, as part of the Hubble Space Telescope Key Project on the Extragalactic Distance Scale. Thirteen F555W (V) and four F814W (I) epochs of cosmic-ray-split Wide Field and Planetary Camera 2 observations were obtained. Twenty Cepheids were discovered, with periods ranging from 12 to 49 days. Adopting a Large Magellanic Cloud distance modulus and extinction of 18.50+/-0.10 mag and E(V-I)=0.13 mag, respectively, a true reddening-corrected distance modulus (based on an analysis employing the ALLFRAME software package) of 30.50 +/- 0.16 (random) +/- 0.17 (systematic) mag was determined for NGC 4725. The corresponding of distance of 12.6 +/- 1.0 (random) +/- 1.0 (systematic) Mpc is in excellent agreement with that found with an independent analysis based upon the DoPHOT photometry package. With a foreground reddening of only E(V-I)=0.02, the inferred intrinsic reddening of this field in NGC 4725, E(V-I)=0.19, makes it one of the most highly-reddened, encountered by the HST Key Project, to date.Comment: To be published in The Astrophysical Journal, Vol. 512 (1999). 34 pages, LaTeX, 9 jpg figure