Genotype moderates the impact of food additives on hyperactive behavior in children

Introduction: The claim of a relationship between artificial food color and additive (AFCs) intake and behavior is highly contentious. We have shown in a previous population-based trial with 3yo children adverse effects of food additives on parentally-rated hyperactive behaviour (Bateman et al, 2004). The possible role of genetic polymorphisms in moderating this adverse effect has not been previously examined. Methods A randomised, double blind, placebo-controlled, within subject crossover food challenge was used for 144, 8 to 9 year old children and 153, 3 year old children. Following baseline assessment children were placed on a diet eliminating food additives and a benzoate preservative for 6 weeks during which time they were challenged for weekly periods with either a placebo mix or a drink containing sodium benzoate (45mg daily) and one of two mixes of AFCs.: Results: The T939C and Thr105Ile polymorphisms of the histamine N-methyltransferase gene (HNMT) moderated the adverse effect s of AFCs but the polymorphisms in catecholamine genes COMT Val108Met and ADRA2A C1291G did not. These findings point to a possible role for histamine in mediating the effects of food additives and help to explain why there has been inconsistency between previous studies. Conclusions: Genes influencing a range of neurotransmitter systems and their interplay with environmental factors, such as diet, need to be examined to understand genetic influences on hyperactivity.<br/

Impacts of Extension Education on Improving Residential Stormwater Quality: Monitoring Results

The project reported in this article evaluated whether stormwater quality could be improved by educating homeowners and implementing best management practices in a suburban neighborhood. Nitrogen, phosphorus, and bacteria levels from two watersheds were compared using the paired watershed approach. Resident surveys, property site assessments, soil tests, and water quality and quantity monitoring were conducted. A x2-analysis of survey data indicated no significant changes in measured behavior. Significant (p=0.01) reductions in NO3-N and fecal coliform bacteria concentrations occurred; however, total nitrogen concentrations did not change significantly

Comparative Toxicity of Diphacinone to Northern Bobwhite (\u3ci\u3eColinus virginianus\u3c/i\u3e) and American Kestrels (\u3ci\u3eFalco sparverius\u3c/i\u3e)

The acute oral toxicity of the anticoagulant rodenticide diphacinone was found to be about 20 times greater to American kestrels (LD50=97 mg/kg) than to northern bobwhite (LD50=2,014 mg/kg). Several precise and sensitive clotting assays (prothrombin time, Russell’s Viper venom time, thrombin clotting time) were adapted for use in these species, and this combination of assays is recommended to detect effects of diphacinone and other rodenticides on coagulation. Oral administration of diphacinone over a range of doses (sublethal to the extrapolated LD15) prolonged prothrombin time and Russell’s Viper venom time within 24 to 48 hrs post-exposure. Prolongation of in vitro clotting time reflects impaired coagulation complex activity and was detected before or at the onset of overt signs of toxicity and lethality. These data will assist in the development of a pharmacodynamic model to assess and predict rodenticide toxicity to non-target avian species

Comparative Toxicity of Diphacinone to Northern Bobwhite (\u3ci\u3eColinus virginianus\u3c/i\u3e) and American Kestrels (\u3ci\u3eFalco sparverius\u3c/i\u3e)

The acute oral toxicity of the anticoagulant rodenticide diphacinone was found to be about 20 times greater to American kestrels (LD50=97 mg/kg) than to northern bobwhite (LD50=2,014 mg/kg). Several precise and sensitive clotting assays (prothrombin time, Russell’s Viper venom time, thrombin clotting time) were adapted for use in these species, and this combination of assays is recommended to detect effects of diphacinone and other rodenticides on coagulation. Oral administration of diphacinone over a range of doses (sublethal to the extrapolated LD15) prolonged prothrombin time and Russell’s Viper venom time within 24 to 48 hrs post-exposure. Prolongation of in vitro clotting time reflects impaired coagulation complex activity and was detected before or at the onset of overt signs of toxicity and lethality. These data will assist in the development of a pharmacodynamic model to assess and predict rodenticide toxicity to non-target avian species

The Ursinus Weekly, February 28, 1949

Ruby staff sought; Junior class hopes to better yearbook • Sophs choose Woody Leigh for hop • IRC group travels to Norristown High, hears commentator • Pancoast to speak to PAC commission on Congress topic • Hoopsters, Maulers to finish seasons; coeds to continue • Curtain Club groups present entertaining bevy of events • Parking offenders to pay fines • Pancoasts head Red Cross drive • Juniors to hold television show featuring music, food, variety • Do you favor the North Atlantic Pact? • Radio station sees hope for wider use of talent • Belles lose second as Chestnut Hillers take 35-22 victory • Both sexes reach stride in campus court strife • Jaffe gets award from Philly scribes • Haverford to meet bruins in opener of baseball season • Bruin matmen take two as Drexel and CCNY fall • Coeds trip Temple; last period surge sets total at 43-39 • Grizzlies fail to win in three court battles • Cadets retain lead in MA court race • Messiah group heard on WNARhttps://digitalcommons.ursinus.edu/weekly/1609/thumbnail.jp

Photonic band structure of highly deformable, self-assembling systems

We calculate the photonic band structure at normal incidence of highly deformable, self-assembling systems - cholesteric elastomers subjected to external stress. Cholesterics display brilliant reflection and lasing owing to gaps in their photonic band structure. The band structure of cholesteric elastomers varies sensitively with strain, showing new gaps opening up and shifting in frequency. A novel prediction of a total band gap is made, and is expected to occur in the vicinity of the previously observed de Vries bandgap, which is only for one polarisation

1RXS J232953.9+062814: A Dwarf Nova with a 64-minute Orbital Period and a Conspicuous Secondary Star

We present spectroscopy and time-series photometry of the newly discovered dwarf nova 1RXS J232953.9+062814. Photometry in superoutburst reveals a superhump with a period of 66.06(6) minutes. The low state spectrum shows Balmer and HeI emission on a blue continuum, and in addition shows a rich absorption spectrum of type K4 +- 2. The absorption velocity is modulated sinusoidally at P_orb = 64.176(5) min, with semi-amplitude K = 348(4) km/s. The low-state light curve is double-humped at this period, and phased as expected for ellipsoidal variations. The absorption strength does not vary appreciably around the orbit. The orbital period is shorter than any other cataclysmic variable save for a handful of helium-star systems and V485 Centauri (59 minutes). The secondary is much hotter than main sequence stars of similar mass, but is well-matched by helium-enriched models, indicating that the secondary evolved from a more massive progenitor. A preliminary calculation in which a 1.2 solar-mass star begins mass transfer near the end of H burning matches this system's characteristics remarkably well.Comment: accepted to Astrophysical Journal Letters; 14 pages, 3 eps figures + 1 jpg greyscale figur

A Computationally-Efficient Probabilistic Approach to Model-Based Damage Diagnosis

This work presents a computationally-efficient, probabilistic approach to model-based damage diagnosis. Given measurement data, probability distributions of unknown damage parameters are estimated using Bayesian inference and Markov chain Monte Carlo (MCMC) sampling. Substantial computational speedup is obtained by replacing a three-dimensional finite element (FE) model with an efficient surrogate model. While the formulation is general for arbitrary component geometry, damage type, and sensor data, it is applied to the problem of strain-based crack characterization and experimentally validated using full-field strain data from digital image correlation (DIC). Access to full-field DIC data facilitates the study of the effectiveness of strain-based diagnosis as the distance between the location of damage and strain measurements is varied. The ability of the framework to accurately estimate the crack parameters and effectively capture the uncertainty due to measurement proximity and experimental error is demonstrated. Furthermore, surrogate modeling is shown to enable diagnoses on the order of seconds and minutes rather than several days required with the FE model

Inner-shelf ocean dynamics and seafloor morphologic changes during Hurricane Sandy

This paper is not subject to U.S. copyright. The definitive version was published in Continental Shelf Research 138 (2017): 1-18, doi:10.1016/j.csr.2017.02.003.Hurricane Sandy was one of the most destructive hurricanes in US history, making landfall on the New Jersey coast on October 30, 2012. Storm impacts included several barrier island breaches, massive coastal erosion, and flooding. While changes to the subaerial landscape are relatively easily observed, storm-induced changes to the adjacent shoreface and inner continental shelf are more difficult to evaluate. These regions provide a framework for the coastal zone, are important for navigation, aggregate resources, marine ecosystems, and coastal evolution. Here we provide unprecedented perspective regarding regional inner continental shelf sediment dynamics based on both observations and numerical modeling over time scales associated with these types of large storm events. Oceanographic conditions and seafloor morphologic changes are evaluated using both a coupled atmospheric-ocean-wave-sediment numerical modeling system that covered spatial scales ranging from the entire US east coast (1000 s of km) to local domains (10 s of km). Additionally, the modeled response for the region offshore of Fire Island, NY was compared to observational analysis from a series of geologic surveys from that location. The geologic investigations conducted in 2011 and 2014 revealed lateral movement of sedimentary structures of distances up to 450 m and in water depths up to 30 m, and vertical changes in sediment thickness greater than 1 m in some locations. The modeling investigations utilize a system with grid refinement designed to simulate oceanographic conditions with progressively increasing resolutions for the entire US East Coast (5-km grid), the New York Bight (700-m grid), and offshore of Fire Island, NY (100-m grid), allowing larger scale dynamics to drive smaller scale coastal changes. Model results in the New York Bight identify maximum storm surge of up to 3 m, surface currents on the order of 2 ms−1 along the New Jersey coast, waves up to 8 m in height, and bottom stresses exceeding 10 Pa. Flow down the Hudson Shelf Valley is shown to result in convergent sediment transport and deposition along its axis. Modeled sediment redistribution along Fire Island showed erosion across the crests of inner shelf sand ridges and sedimentation in adjacent troughs, consistent with the geologic observations.This research was funded by the U.S. Geological Survey (USGS), Coastal and Marine Geology Program, and conducted by the Coastal Change Processes Project. This research was supported in part by the Department of the Interior Hurricane Sandy Recovery program