Neptunism and transformism:Robert Jameson and other evolutionary theorists in early nineteenth-century Scotland

This paper sheds new light on the prevalence of evolutionary ideas in Scotland in the early nineteenth century and establish what connections existed between the espousal of evolutionary theories and adherence to the directional history of the earth proposed by Abraham Gottlob Werner and his Scottish disciples. A possible connection between Wernerian geology and theories of the transmutation of species in Edinburgh in the period when Charles Darwin was a medical student in the city was suggested in an important 1991 paper by James Secord. This study aims to deepen our knowledge of this important episode in the history of evolutionary ideas and explore the relationship between these geological and evolutionary discourses. To do this it focuses on the circle of natural historians around Robert Jameson, Wernerian geologist and professor of natural history at the University of Edinburgh from 1804 to 1854. From the evidence gathered here there emerges a clear confirmation that the Wernerian model of geohistory facilitated the acceptance of evolutionary explanations of the history of life in early nineteenth-century Scotland. As Edinburgh was at this time the most important center of medical education in the English-speaking world, this almost certainly influenced the reception and development of evolutionary ideas in the decades that followed.</p

A high throughput experimental approach to identify miRNA targets in human cells

The study of human microRNAs is seriously hampered by the lack of proper tools allowing genome-wide identification of miRNA targets. We performed Ribonucleoprotein ImmunoPrecipitation—gene Chip (RIP-Chip) using antibodies against wild-type human Ago2 in untreated Hodgkin lymphoma (HL) cell lines. Ten to thirty percent of the gene transcripts from the genome were enriched in the Ago2-IP fraction of untreated cells, representing the HL miRNA-targetome. In silico analysis indicated that ∼40% of these gene transcripts represent targets of the abundantly co-expressed miRNAs. To identify targets of miR-17/20/93/106, RIP-Chip with anti-miR-17/20/93/106 treated cells was performed and 1189 gene transcripts were identified. These genes were analyzed for miR-17/20/93/106 target sites in the 5′-UTRs, coding regions and 3′-UTRs. Fifty-one percent of them had miR-17/20/93/106 target sites in the 3′-UTR while 19% of them were predicted miR-17/20/93/106 targets by TargetScan. Luciferase reporter assay confirmed targeting of miR-17/20/93/106 to the 3′-UTRs of 8 out of 10 genes. In conclusion, we report a method which can establish the miRNA-targetome in untreated human cells and identify miRNA specific targets in a high throughput manner. This approach is applicable to identify miRNA targets in any human tissue sample or purified cell population in an unbiased and physiologically relevant manner

Completing the Pensions Task: Infrastructure For Nationally Coordinated Private Schemes

Abstract: State-sponsored private pension schemes generally provide retirees with a lump sum, but do nothing to assist them with its conversion to an income stream. An optimal way to affect this conversion is to purchase a guaranteed term-certain annuity with part of the sum, while investing the remainder in a national bourse index fund. At present annuities must be purchased from commercial providers. If Government were to issue part of its public debt in the form of annuity bonds, retirees could purchase riskless annuities at lower cost, with government being involved in the pension scheme throughout all phase

Quaestiones Quatuor Voluminum scripti Oxoniensis super sententias & Quolibeta A.R. A.P. Fr. Antonio Barros ... accurate recognitae ... hujus Operis editionem quinque voluminibus ... publicae luci & utilitate datae Tom. I - [IV] ...

Contén: I, Tomus I, In I Sententiarum. II, Tomus II, In II Sententiarum. III, Tomus III, In III Sententiarum. IV, Tomus IV, In IV Sententiaru

Quaestiones Quatuor Voluminum scripti Oxoniensis super Sententias & Quodlibita ... : Tomus V, cum compendio Quodlibitatorum & Syllabo rerum memorabilium

Sign.: A\p1\

Consumer insolvency in Australia

This paper seeks to identify and assess the features of Australian bankruptcy regulation as they apply to consumer insolvency. Although Australian bankruptcy law makes no explicit recognition of 'consumer bankruptcy' as a regulatory target in itself, the Australian legislation nevertheless has a number of features that impact on what would generally be seen to be consumer bankrupts. After providing an outline of the legislative framework within which consumer bankruptcy operates, the paper examines the consumer insolvency aspects of this legislation, together with an assessment of proposed reforms. Some brief comparisons of the ‘consumer’ features of Australian regulation with that of the more fully developed consumer provisions of the Canadian and the United States bankruptcy legislation, are made in order to highlight the Australian position. The Australian Act has historically drawn heavily on English bankruptcy legislation but inevitably Australia has to some extent developed along its own path. Notable is the reasonably vigorous approach to discharge from bankruptcy. The proposed reforms to the Bankruptcy Act, which have followed a detailed consultative process, are largely directed to consumer debtors. Some of these reforms are directed against a perceived debtor abuse of the bankruptcy system. Other reforms, such as increasing the availability of debt agreements, are more generous to insolvent debtors. On the whole the reforms appear to be based more on political than empirical grounds

Questiones subtilissime Scoti in Metaphysicam Aristotelis ; eiusdem De primo rerum principio tractatus ; atq[ue] Theoremata

Editor: Mauritius Hibernicus --BMC -- Marca de impresor en el último folio -- Tipos góticos de dos medidas y 2 columnas -- Letras capitales ornadasAquest incunable s'ha digitalitzat gràcies a una subvenció atorgada pel Ministeri de Cultura d'Espany