Ultra-smooth lithium niobate micro-resonators by surface tension reshaping

Thermal treatment of micro-structured lithium niobate substrates at temperatures close to, but below the melting point, allows surface tension to reshape a preferentially melted surface zone [1] of the crystal to form ultra-smooth single crystal toroidal or spherical structures. Such structures, an example of which is shown in figure 1, are suitable for the fabrication of photonic micro-resonators with low scattering loss. The thermally treated material maintains its single crystal nature after the thermal treatment because the bulk remains solid throughout the process acting as seed during the recrystallization process which takes place during the cooling stage. The single crystal nature of the reshaped material has been verified by piezoresponse force microscopy, Raman spectroscopy and chemical etching. The inherent properties of lithium niobate crystals (optically nonlinear, piezoelectric and electro-optic) makes the resultant micro-resonator extremely suitable for sensing applications, for the production of micro-lasers (if doped with Er or Nd), for nonlinear frequency generation and finally for switching/modulation and tunable spectral filtering in optical telecommunications. The transformation of the initial surface micro-structures to the resulting resonator structure is a temperature dependent process as the surface tension acts on the surface melted layer of the crystal, Experimental investigation and modelling of the thermal treatment as well as investigation of the performance of these microresonators is underway to establish full control of the fabrication process for practical applications

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton’s tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS

[De geometricis principiis]

Marca tip. en port. y al fin.Sign.: a4, A-2P4, 2Q6

Título: Fabellae [sic] graece & latine, cum alijs opusculis ...

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 2007Texto paralelo latin - griegoMarca tip. en port. y v. de ultima h.ColofonSign.: a-z\p8\

Not Available

Not AvailableRice grows mostly in tropical and subtropical regions, but it’s very sensitive to higher temperature during reproductive stage especially flowering anthesis. It is necessary to identify genetic donors for heat stress from high temperature rice growing environments. Temperature stress effects at reproductive stage by adopting three different planting dates with 15 days interval each in Environment-1 (e1), Environment-2 (e2) and Environment-3 (E3) with forty-three rice genotypes was studied. The temperature regimes were 35.60C (E1) to 39.2 (E3) at reproductive stage. From the results of AMMI analysis, the environment (E2) was found to be ideal for better identification of genotypes for heat tolerance with desirable traits. The elevated temperature at the time of flowering and maturity determines the yield per se of the genotypes. The hybrids adapted better than parental lines, showing the buffering nature and heterosis for stress tolerance. Under high temperature stress, the response of genotypes depended on developmental stage, but highest sensitivity was recorded at reproductive stage. The time of sowing, days to flowering (duration group), heat escape (early morning flowering) and inbuilt tolerance were the crucial factors in determining the performance of genotypes to varying temperature. Hence, it is necessary to select genotypes by keeping in view the above factors for different temperature stress within and across the environment.Not Availabl

In C. Iul. Caesaris commentarios, notae, adnotationes, commentarii Rhellicani, Glareani, Glandorpii, Camerarii, Bruti, Manutii, Sambuci, Ursini, Ciacconii, Hotmani, Brantii ; Nomenclator geographicus praeterea duplex, e quibus alter R. Marliani...

Marca tip. en port. y al finEnc. Perg.Sign.: a4, b-z8, aa-dd8, ee4, ff-mm8, aaa-bbb8, ccc4, ddd

Peripheral Solitary Osteoma of the Zygomatic Arch: A Case Report and Literature Review

Osteoma is a benign slow-growing osteogenic neoplasm commonly occurring in the craniofacial skeleton, characterized by the proliferation of compact and/or cancellous bone. Osteomas may be peripheral, central, or extraskeletal. Peripheral osteomas arise from the periosteum and are quite uncommon in the jaw bones. The exact aetiology and pathogenesis of peripheral osteoma are unknown. Clinically, peripheral osteomas are usually asymptomatic, but depending on the location and size of the lesion, it may cause swelling, pain, esthetic disfigurement and functional impairment. On radiological imaging, a peripheral osteoma appears often as well-circumscribed, round to oval, pedunculated radiopaque mass attached to the cortex by a broad base or a pedicle. Asymptomatic osteomas are treated conservatively, while surgical excision is indicated when the lesion is symptomatic, actively growing, or for cosmetic reasons. Histologically, osteomas are composed of a normal-appearing, dense mass of lamellar bone. Recurrence of peripheral osteoma after surgical removal is extremely rare and there are no reports of malignant transformation. A review of the literature disclosed only 7 well-documented cases of peripheral osteoma located at the zygomatic bone. The purpose of this article is to present the clinical, radiographic, surgical and histological features of a solitary peripheral osteoma of the left zygomatic arch in a 55-year-old woman and to review the literature about this uncommon pathologic entity