Indications for antibiotic treatment before bacteriology results.

<p>Indications for antibiotic treatment before bacteriology results.</p

Data regarding number of patients included, treated according to protocol and followed up at 21 and 90 days.

<p>Data regarding number of patients included, treated according to protocol and followed up at 21 and 90 days.</p

Treatments authorized in the study.

*<p>Aminoglycosides were administered in a single dose with a loading dose on the first day of treatment. The dose was adapted in the event of renal failure.</p

Microbiology of secondary infections.

*<p>CSF,</p>‡<p>pleural fluid,</p>**<p>chest drain,</p>§<p>ESBL (Extended-Spectrum Beta-Lactamase),</p><p>CAZ-S^† (sensitive to ceftazidime),</p><p>CAZ-R^†† (resistant to ceftazidime),</p>‡‡<p>Reduced sensitivity to beta-lactams and high-level aminoglycoside resistance,</p>§§<p>Sensitive to chloramphenicol, cyclins, vancomycin, teicoplanin.</p

Definition of secondary infections requiring the initiation of antibiotic treatment for more than 48 hours.

<p>Definition of secondary infections requiring the initiation of antibiotic treatment for more than 48 hours.</p

Patients with documented secondary infections.

<p>Abbreviations:</p>*<p>sensitive,</p>†<p>resistant,</p>**<p>Fischer exact test.</p

Admission characteristics of the study patients according to the duration of antibiotic treatment.

<p>Abbreviations:</p>*<p>RTA: road traffic accident;</p>†<p>SAPS: simplified acute physiological score;</p>‡<p>ICU: intensive care unit;</p>§<p>BAL: bronchoalveolar lavage;</p>**<p>3GC: third generation cephalosporin.</p

Comparisons between patients with and without secondary infections.

<p>Abbreviations:</p>†<p>SAPS: simplified acute physiological score;</p>‡<p>ICU: intensive care unit;</p>§<p>BAL: bronchoalveolar lavage;</p>*<p>3GC: third generation cephalosporin;</p>**<p>all molecules grouped together.</p

Definition of intercurrent adverse events.

*<p>World Health Organisation rating.</p

Exclusion criteria.

<p>Exclusion criteria.</p