Co-occurrence of two cases of progressive multifocal leukoencephalopathy in a natalizumab ``infusion group''

We observed two cases of progressive multifocal leukoencephalopathy (PML) that occurred in the same infusion group. The group consisted of four patients with relapsing-remitting multiple sclerosis (RRMS) who had been treated with natalizumab (NAT) in the same medical practice for more than four years at the same times and in the same room, raising concerns about viral transmission between members of the infusion group. DNA amplification and sequence comparison of the non-coding control region (NCCR) of JC virus (JCV) present in cerebrospinal fluid (CSF) samples from PML patients #1 and #2 revealed that the amplified JCV sequences differed from the JCV archetype. The NCRR of the viral DNA was unique to each patient, arguing against the possibility of viral transmission between patients. Statistical considerations predict that similar co-occurrences of PML are likely to happen in the future

Co-occurrence of two cases of progressive multifocal leukoencephalopathy in a natalizumab ``infusion group''

We observed two cases of progressive multifocal leukoencephalopathy (PML) that occurred in the same infusion group. The group consisted of four patients with relapsing-remitting multiple sclerosis (RRMS) who had been treated with natalizumab (NAT) in the same medical practice for more than four years at the same times and in the same room, raising concerns about viral transmission between members of the infusion group. DNA amplification and sequence comparison of the non-coding control region (NCCR) of JC virus (JCV) present in cerebrospinal fluid (CSF) samples from PML patients #1 and #2 revealed that the amplified JCV sequences differed from the JCV archetype. The NCRR of the viral DNA was unique to each patient, arguing against the possibility of viral transmission between patients. Statistical considerations predict that similar co-occurrences of PML are likely to happen in the future

Abstract AUTOMATIC GENERATION OF DIVERSIFIED PROGRAM VARIANTS OPTIMIZED TO DETECT HARDWARE FAULTS

A virtual duplex system can be used to increase safety without the use of structural redundancy on a single machine. If a program P is calculating a given function f, then a virtual duplex system con-tains two variants Pa and Pb of P which are calculating the diverse functions fa and fb, respectively. If no error occurs in the process of designing and executing Pa and Pb then f = fa = fb holds. For a given input i the VDS calculates and compares the values fa(i) and fb(i). The presence of an error can be detected if fa(i) <> fb(i). This paper outlines the design of a Pentium II based system which aims at the automatic generation of VDS's with a high detection probability for hardware faults. 1

Fast-Speech-Induced Hypoarticulation Does Not Considerably Affect the Diachronic Reversal of Complementary Length in Central Bavarian

This study investigated a sound change in progress by which the Central Bavarian dialect feature of complementary length between consonant and the preceding vowel is giving way to the unrestricted combination possibility of long (Vː) and short (V) vowels with following longer fortis (Cː) and shorter lenis (C) stops, respectively. This 2 × 2 system is also found in the standard variety of German. While previous studies have regarded any such findings of convergence toward Standard German as being a result of language contact, the present study specifically tested the possibility of fast-speech-induced hypoarticulation being a system-internal driver of this change. The focus of this study was on acoustic cues to the postvocalic stop. Following the apparent-time paradigm, acoustic analyses of 10 younger and 10 older dialect speakers revealed that (1) younger dialect speakers produced both VC and VːCː (both formerly illegal in the dialect), but (2) older dialect speakers produced only VːCː sequences with duration patterns similar to those of the control group of 10 Standard German speakers. Analyses of various dependent variables further showed (3) the (apparently) delayed emergence of aspiration as an additional cue to the fortis–lenis contrast in Western Central Bavarian particularly in younger dialect speakers, (4) no considerable effect of speech rate on the dispersion of and overlap between any of the four vowel-plus-stop combinations, and (5) the irregular spread of this change that appears to be gradual. As such, the findings support a model of linguistic change that also accounts for gradual changes in dialect borrowing

What do Finnish and Central Bavarian have in common? Towards an acoustically based quantity typology

R data frame and R script to accompany the conference paper

Data and code for “Reconstructing the timeline of a consonantal change in a German dialect: Evidence from agent-based modeling”

Supplementary material to accompany the paper. This is mostly R code and raw data to reproduce the results and figures