A study correlating nerve biopsy with clinical diagnosis and its impact on improving management in peripheral neuropathies

Background: This study attempts to evaluate the utility of nerve biopsy in complementing or redirecting clinical diagnosis. Several factors determine the diagnostic utility of nerve biopsy, the most important being pre-biopsy diagnosis, with higher diagnostic yield reported in asymmetric and multi-focal neuropathies. Methods: This retrospective study was conducted at a tertiary care hospital in South India, wherein, patients with a clinical and electrophysiological diagnosis of peripheral neuropathy who underwent nerve biopsy between Jan 2012- Dec 2016 were reviewed. Results: A total of 112 nerve biopsies were performed at our Institute during the study period, of which, 84 had adequate information for review and inclusion in the study. In a majority (75) Sural nerve was biopsied, followed by combined superficial peroneal nerve and peroneus tertius muscle biopsy (5).Nerve biopsy diagnosis was concordant with and helped confirm the clinical diagnosis in 43/84 (51%) cases, which included vasculitic neuropathy (20), CIDP (16), leprous neuropathy (6). In10/84 (12%) patients, the nerve biopsy diagnosis was discordant with the clinical diagnosis and helped in redirecting management. This included vasculitic and diabetic neuropathy (2 each), Charcot Marie Tooth Disease (3), and leprous neuropathy (3). In 31/85 (37%) cases with no clinically evident etiological diagnosis, nerve biopsy proved useful in establishing diagnosis in 16/31 (51%) cases aiding patient management. This included Non-systemic vasculitic neuropathy (7), leprous neuropathy (3), diabetic neuropathy (2), and Giant axonal neuropathy (1). Conclusion: Nerve biopsy remains a valuable tool in complementing or redirecting the clinical diagnosis, and improving the therapeutic outcomes in peripheral neuropathies. It should be done upfront in clinically idiopathic neuropathies, and early at follow up in treatment refractory neuropathies

Intrapartum Amnioinfusion in Meconium-Stained Amniotic Fluid- A Randomized Control Study in A Tertiary Care Hospital

Objective: The study was undertaken to evaluate maternal and Perinatal outcomes following transcervical intrapartum amnioin- fusion in women with meconium stained amniotic fluid. Methods: A randomized control study was conducted on 200 women with moderate to thick meconium stained amniotic fluid during labor. Group A (study group) of 100 cases received amnio- infusion. Group B (control group) of 100 cases received standard obstetric care. Fetal heart rate monitoring was done using cardioto- cography. Results: 66% of women were in the age group of 21-25 years. Av- erage cervical dilatation at detection of meconium and detection of meconium to delivery interval was similar in both groups. In the study group, 68% women had normal vaginal delivery as com- pared to 49% in the control group (p<0.01). Operative delivery was required in 32% and 51% cases in groups A and B respectively. Me- conium aspiration syndrome was developed in 5% cases in group A and 15% cases in group B (p=0.02, Odds ratio 0.29 (0.1-0.85)). There were no differences in Apgar scores, NICU admissions and Perinatal mortality between two groups. No any maternal compli- cations were noted due to amnioinfusion. Conclusion: Intrapartum amnioinfusion in meconium stained am- niotic fluid is simple, safe and inexpensive intervention to reduce the rates of meconium aspiration syndrome and its complications