OXIDATIVE STRESS IN ACNE VULGARIS

Objective: Acne vulgaris is a common dermatological disease characterized by sebaceous hyperplasia, follicular hyperkeratinization, Immune reactions, and Inflammation. Our study aims to determine the role of oxidative stress in the pathogenesis of acne vulgaris. Methods: 35 acne patients and 35 healthy people were selected and their serum levels of superoxide dismutase SOD and Malondialdehyde MDA were estimated and the results are compared with the control group. Also, the relationship between the duration and severity of acne with the parameters is assessed. Results: The activity of SOD is found to be decreased and the level of MDA is found to be increased in acne patients compared to healthy people, suggesting increased oxidative stress in Acne vulgaris patients. Conclusion: Our study concludes that oxidative stress plays a role in the pathogenesis of Acne vulgaris and antioxidants can be used as a part of treatment.

Antibacterial and wound healing activities of melastoma malabathricum linn.

Melastoma malabathricum Linn. (Melastomataceae), locally known as senduduk putih, is a wellknown plant in Malaysian traditional medicine. On the basis of its traditional use and literature reference,this plant was selected for evaluation of its wound healing and antibacterial activities. Methanol extract of M. malabathricum was examined for its wound healing activity in the form of an ointment in two types of wound model in rats: (i) the excision wound model and (ii) the incision wound model. The methanol extract ointment produced a significant response in both of the wound types tested. The results were also comparable with the standard drug, nitrofurazone, in terms of wound contracting ability, wound closure time, tensile strength and regeneration of tissues at the wound site. Regarding antibacterial activity, M. malabathricum extract inhibited the different clinical wound isolates of S. aureus and P. aeruginosa with MIC ranging from 3.0 mg/ml for 3 of the 4 clinical strains of S. aureus to 8.0 mg/ml for all the 3 clinical strains of P. aeruginosa tested.Keywords: Melastoma malabathricum; Antibacterial; Methanol extract; Wound healing

Is flood to drip irrigation a solution to groundwater depletion in the Indo-Gangetic plain?

Indian river basins are intensively managed with country-specific agricultural practices of cultivating submerged paddy and uncontrolled groundwater (GW) irrigation. Numerical experiments with the state-of-the-art land surface models, such as variable infiltration capacity (VIC), without incorporating region-specific practices, could be misleading. Here, we coupled VIC with 2D GW model AMBHAS, incorporating India-specific irrigation practices and crop practices, including submerged paddy fields. We performed numerical experiments to understand the causal factors of GW depletion in the northwest Indo-Gangetic plain (IGP). We identify widespread flood irrigation and cultivation of water-intensive paddy as critical drivers of the declining GW scenario. Our numerical experiments suggest that the introduction of drip irrigation reduces GW depletion in the northwest, but does not change the sign of GW level trends. The GW levels in the non-paddy fields of the middle IGP are less sensitive to irrigation practices due to the high return flow to GW for flood irrigation

Effects of salinity and drought on growth, ionic relations, compatible solutes and activation of antioxidant systems in oleander (Nerium oleander L.)

[EN] Nerium oleander is an ornamental species of high aesthetic value, grown in arid and semi- arid regions because of its drought tolerance, which is also considered as relatively resistant to salt; yet the biochemical and molecular mechanisms underlying oleander¿s stress toler- ance remain largely unknown. To investigate these mechanisms, one-year-old oleander seedlings were exposed to 15 and 30 days of treatment with increasing salt concentratio ns, up to 800 mM NaCl, and to complete withholding of irrigation; growth parameters and bio- chemical markers characteristic of conserved stress-response pathways were then deter- mined in stressed and control plants. Strong water deficit and salt stress both caused inhibition of growth, degradation of photosynthetic pigments, a slight (but statistically signifi- cant) increase in the leaf levels of specific osmolytes, and induction of oxidative stress¿as indicated by the accumulation of malondialdehyde (MDA), a reliable oxidative stress marker ¿accompanied by increases in the levels of total phenolic compounds and antioxidant fla- vonoids and in the specific activities of ascorbate peroxidase (APX) and glutathione reduc- tase (GR). High salinity, in addition, induced accumulation of Na + and Cl - in roots and leaves and the activation of superoxide dismutase (SOD) and catalase (CAT) activities. Apart from anatomical adaptations that protect oleander from leaf dehydration at moderate levels of stress, our results indicate that tolerance of this species to salinity and water deficit is based on the constitutive accumulation in leaves of high concentratio ns of soluble carbohydrates and, to a lesser extent, of glycine betaine, and in the activation of the aforementioned antiox- idant systems. Moreover, regarding specifically salt stress, mechanisms efficiently blocking transport of toxic ions from the roots to the aerial parts of the plant appear to contribute to a large extent to tolerance in Nerium oleanderThis work was financed by internal funds of the Polytechnic University of Valencia to Monica Boscaiu and Oscar Vicente. Dinesh Kumar’s stay in Valencia was financed by a NAMASTE fellowship from the European Union, and Mohamad Al Hassan was a recipient of an Erasmus Mundus pre-doctoral scholarship financed by the European Commission (Welcome Consortium).Kumar, D.; Al Hassan, M.; Naranjo Olivero, MA.; Agrawal, V.; Boscaiu, M.; Vicente, O. (2017). Effects of salinity and drought on growth, ionic relations, compatible solutes and activation of antioxidant systems in oleander (Nerium oleander L.). PLoS ONE. 12(9). doi:10.1371/journal.pone.0185017Se018501712

Effects of biofertilizer containing N-fixer, P and K solubilizers and AM fungi on maize growth: A greenhouse trial.

An in vitro study was undertaken to evaluate the compatibility of indigenous plant growth promoting rhizobacteria (PGPR) with commonly used inorganic and organic sources of fertilizers in tea plantations. The nitrogenous, phosphatic and potash fertilizers used for this study were urea, rock phosphate and muriate of potash, respectively. The organic sources of fertilizers neem cake, composted coir pith and vermicompost were also used. PGPRs such as nitrogen fixer; Azospirillum lipoferum, Phosphate Solubilizing Bacteria (PSB); Pseudomonas putida, Potassium Solubilizing Bacteria (KSB); Burkholderia cepacia and Pseudomonas putida were used for compatibility study. Results were indicated that PGPRs preferred the coir pith and they proved their higher colony establishment in the formulation except Azospirillum spp. that preferred vermicompost for their establishment. The optimum dose of neem cake powder

Foraminiferal and sediment geochemistry studies in and around Cochin backwaters, southwest coast of India

2303-2313Based on the foraminiferal studies, 25 foraminifera taxa belonging to 16 genera, 13 families, 10 superfamilies, and 6 suborder have been identified. Various sedimentological parameters such as CaCO3, Organic matter and sand-silt-clay ratio were determined for the samples in order to study the relationship between substrate and foraminiferal populations, and to evaluate the favoured substrate of dominant species populations. Foraminiferal assemblages are more in the silty sand and sand substrate environments. Based on the foraminiferal distribution, in the upper part of the estuary, species diversity are very rare in abundance due to the tidal fluctuation the species are distributed in this region.  In the middle estuary due to the mixing of estuarine and marine influence, the diversity is lesser in amount. In the lower estuary near the seashore the species diversity is slightly higher than the middle estuary due to the salinity influence and the open ocean conditions

Analgesic and Antipyretic Effects of Sansevieria Trifasciata Leaves

The ethanol and water extracts of Sansevieria trifasciata leaves showed dose-dependent and significant (P < 0.05) increase in pain threshold in tail-immersion test. Moreover, both the extracts (100 – 200 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P < 0.001) inhibition of both phases of the formalin pain test. The ethanol extract (200 mg/kg) significantly (P < 0.01) reversed yeast-induced fever. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, flavonoids, saponins, glycosides, terpenoids, tannins, proteins and carbohydrates