Iridium(III)-Catalyzed Synthesis of Benzimidazoles via C–H Activation and Amidation of Aniline Derivatives

Ir­(III)-catalyzed synthesis of benzimidazoles has been realized under redox-neutral conditions by annulation of aniline derivatives with dioxazolones. The reaction proceeded via a C–H activation–amidation–cyclization pathway with a decent substrate scope

Access to Substituted Propenoic Acids via Rh(III)-Catalyzed C–H Allylation of (Hetero)Arenes with Methyleneoxetanones

An efficient synthesis of disubstituted acrylic acids has been realized via Rh­(III)-catalyzed C–H activation of (hetero)­arenes and coupling with four-membered methyleneoxetanones under redox-neutral conditions. In most cases, the reactions are silver-free, and the products are exclusively <i>E</i>-selective with a broad substrate scope. The transformation proceeds via ortho C–H activation followed by selective olefin insertion and β-oxygen elimination

Access to Substituted Propenoic Acids via Rh(III)-Catalyzed C–H Allylation of (Hetero)Arenes with Methyleneoxetanones

An efficient synthesis of disubstituted acrylic acids has been realized via Rh­(III)-catalyzed C–H activation of (hetero)­arenes and coupling with four-membered methyleneoxetanones under redox-neutral conditions. In most cases, the reactions are silver-free, and the products are exclusively <i>E</i>-selective with a broad substrate scope. The transformation proceeds via ortho C–H activation followed by selective olefin insertion and β-oxygen elimination

Rh(III)-Catalyzed Acceptorless Dehydrogenative Coupling of (Hetero)arenes with 2‑Carboxyl Allylic Alcohols

Rhodium­(III)-catalyzed C–H activation of (hetero)­arenes and redox-neutral coupling with 2-carboxyl allylic alcohols has been realized for the construction of β-aryl ketones. This reaction occurred efficiently at a relatively low catalyst loading via initial dehydrogenative alkylation to give a β-keto carboxylic acid, followed by decarboxylation