A global experience-sampling method study of well-being during times of crisis : The CoCo project

We present a global experience-sampling method (ESM) study aimed at describing, predicting, and understanding individual differences in well-being during times of crisis such as the COVID-19 pandemic. This international ESM study is a collaborative effort of over 60 interdisciplinary researchers from around the world in the “Coping with Corona” (CoCo) project. The study comprises trait-, state-, and daily-level data of 7490 participants from over 20 countries (total ESM measurements = 207,263; total daily measurements = 73,295) collected between October 2021 and August 2022. We provide a brief overview of the theoretical background and aims of the study, present the applied methods (including a description of the study design, data collection procedures, data cleaning, and final sample), and discuss exemplary research questions to which these data can be applied. We end by inviting collaborations on the CoCo dataset

Effects of Lasia spinosa Thw. on growth rate and reproductive hormone of weaned Swamp buffalo and Murrah X Swamp buffalo calves

The effects of Lasia spinosa Thw. on growth rate and plasma Oestradiol 17- β (E2), Progesterone (P4) and Testosterone (T) were studied in 16 male and female swamp (SS) buffaloes and Murrah x Swamp buffalo crossbreeds (MS) calves. The treatment group was fed with a concentrate supplemented with 30 g of dry powder of L. spinosa/head/d for 7 months. It was found that L .spinosa could have effect on male and female buffalo growth rate. The growth rate of male SS treated group were 130 g/d higher than control group. In female both SS and MS buffalo, the highest growth rate (830 to 840 g/d) was found after the 2nd month of treatment while a reduction in growth rate (-1,030 to - 450 g/d) was found in the 3rd month. After that the growth rate of SS and MS gradually increased until the last three months to 200 and 80 g/d in average, respectively. In female MS, plasma E2 in the treated group was lower than control group during Jan to Jul. Similar result was found in SS female, level of plasma E2 in treated group was lower than in control group in the first and last three month and there was no difference of plasma E2 in May. In MS male, the level of plasma E2 of treated group was higher than control group in Jan, Mar, Apr and Jul. In SS male, the level of plasma E2 of treated group was higher than control group in every month except in Jul. In female SS, L. spinosa could decreased plasma P4 through the experiment and could not have an effect on plasma P4 in female MS and plasma T in male buffalo calves. In conclusion, the addition to the concentrate of dry powder of L. spinosa 30 g/headl/d had an effect to increase growth rate in male SS and female MS buffalo calves, decrease plasma E2 in female both SS and MS and male SS and decrease plasma P4 in female SS

A global experience‐sampling method study of well‐being during times of crisis: The CoCo project

We present a global experience-sampling method (ESM) study aimed at describing, predicting, and understanding individual differences in well-being during times of crisis such as the COVID-19 pandemic. This international ESM study is a collaborative effort of over 60 interdisciplinary researchers from around the world in the “Coping with Corona” (CoCo) project. The study comprises trait-, state-, and daily-level data of 7490 participants from over 20 countries (total ESM measurements = 207,263; total daily measurements = 73,295) collected between October 2021 and August 2022. We provide a brief overview of the theoretical background and aims of the study, present the applied methods (including a description of the study design, data collection procedures, data cleaning, and final sample), and discuss exemplary research questions to which these data can be applied. We end by inviting collaborations on the CoCo dataset

Acute HIV-1 infection viremia associate with rebound upon treatment interruption

Background: Analytic treatment interruption (ATI) studies evaluate strategies to potentially induce remission in people living with HIV-1 but are often limited in sample size. We combined data from four studies that tested three interventions (vorinostat/hydroxychloroquine/maraviroc before ATI, Ad26/MVA vaccination before ATI, and VRC01 antibody infusion during ATI). Methods: The statistical validity of combining data from these participants was evaluated. Eleven variables, including HIV-1 viral load at diagnosis, Fiebig stage, and CD4+ T cell count were evaluated using pairwise correlations, statistical tests, and Cox survival models. Findings: Participants had homogeneous demographic and clinical characteristics. Because an antiviral effect was seen in participants who received VRC01 infusion post-ATI, these participants were excluded from the analysis, permitting a pooled analysis of 53 participants. Time to viral rebound was significantly associated with variables measured at the beginning of infection: pre-antiretroviral therapy (ART) viral load (HR = 1.34, p = 0.022), time to viral suppression post-ART initiation (HR = 1.07, p < 0.001), and area under the viral load curve (HR = 1.34, p = 0.026). Conclusions: We show that higher viral loads in acute HIV-1 infection were associated with faster viral rebound, demonstrating that the initial stage of HIV-1 infection before ART initiation has a strong impact on viral rebound post-ATI years later. Funding: This work was supported by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of the Army (W81XWH-18-2-0040). This research was funded, in part, by the US National Institute of Allergy and Infectious Diseases (AAI20052001) and the I4C Martin Delaney Collaboratory (5UM1AI126603-05)