The research progress of next generation risk assessment in cosmetic ingredients and the implications for traditional Chinese medicine risk assessment

Introduction: The advancement and advocacy of the 3R principle and safety evaluation and risk assessment technology has given rise to an innovative method on a global scale, which known as the Next Generation Risk Assessment (NGRA). This progressive approach adopts a tiered assessment strategy based on prepositive hypothesis and exposure analysis. Unlike traditional risk assessment methods that rely on toxicological endpoint animal tests, NGRA lays emphasis on evaluating the exposure process by outlining the mechanisms and significant key events leading to adverse outcomes. The NGRA process entails prioritizing the robust high-throughput screening and prediction tools to enhance the accuracy, efficiency, and relevance of the assessment. Result: This review provides an overview of the principles, framework, and tools of NGRA as recommended by the International Cosmetics Regulatory Cooperation Organization (ICCR). Furthermore, the review encompasses published case studies of cosmetics ingredients and elucidates the potential applications and technical challenges associated with NGRA while considering the extant safety evaluation requirements for cosmetics ingredients in China. Moreover, the review synthesizes a selection of case studies of cosmetics ingredients and hope to proffer implications for the assessment of risk in traditional Chinese medicine. Conclusion: It was hoped to help researchers to investigate novel techniques of safety risk assessment and propose research concepts for both cosmetics and traditional Chinese medicine