Statistical Tests for Replacing Human Decision Makers with Algorithms

This paper proposes a statistical framework with which artificial intelligence can improve human decision making. The performance of each human decision maker is first benchmarked against machine predictions; we then replace the decisions made by a subset of the decision makers with the recommendation from the proposed artificial intelligence algorithm. Using a large nationwide dataset of pregnancy outcomes and doctor diagnoses from prepregnancy checkups of reproductive age couples, we experimented with both a heuristic frequentist approach and a Bayesian posterior loss function approach with an application to abnormal birth detection. We find that our algorithm on a test dataset results in a higher overall true positive rate and a lower false positive rate than the diagnoses made by doctors only. We also find that the diagnoses of doctors from rural areas are more frequently replaceable, suggesting that artificial intelligence assisted decision making tends to improve precision more in less developed regions.Comment: 65 pages, 19 figure

Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos

<p>Abstract</p> <p>Background</p> <p>Patterning along the anterior-posterior (A-P) axis in <it>Drosophila </it>embryos is instructed by the morphogen gradient of Bicoid (Bcd). Despite extensive studies of this morphogen, how embryo geometry may affect gradient formation and target responses has not been investigated experimentally.</p> <p>Results</p> <p>In this report, we systematically compare the Bcd gradient profiles and its target expression patterns on the dorsal and ventral sides of the embryo. Our results support a hypothesis that proper distance measurement and the encoded positional information of the Bcd gradient are along the perimeter of the embryo. Our results also reveal that the dorsal and ventral sides of the embryo have a fundamentally similar relationship between Bcd and its target Hunchback (Hb), suggesting that Hb expression properties on the two sides of the embryo can be directly traced to Bcd gradient properties. Our 3-D simulation studies show that a curvature difference between the two sides of an embryo is sufficient to generate Bcd gradient properties that are consistent with experimental observations.</p> <p>Conclusions</p> <p>The findings described in this report provide a first quantitative, experimental evaluation of embryo geometry on Bcd gradient formation and target responses. They demonstrate that the physical features of an embryo, such as its shape, are integral to how pattern is formed.</p

Controllable Entanglement Distribution Network Based on Silicon Quantum Photonics

The entanglement distribution network connects remote users through sharing entanglement resources, which is essential for realizing quantum internet. We proposed a controllable entanglement distribution network (c-EDN) based on a silicon quantum photonic chip. The entanglement resources were generated by a quantum light source array based on spontaneous four-wave mixing (SFWM) in silicon waveguides and distributed to different users through time-reversed Hong-Ou-Mandel interferences in on-chip Mach-Zehnder interferometers with thermal phase shifters. A chip sample was designed and fabricated, supporting a c-EDN with 3 subnets and 24 users. The network topology of entanglement distributions could be reconfigured in three network states by controlling the quantum interferences through the phase shifters, which was demonstrated experimentally. Furthermore, a reconfigurable entanglement-based QKD network was realized as an application of the c-EDN. The reconfigurable network topology makes the c-EDN suitable for future quantum networks requiring complicated network control and management. Moreover, it is also shows that silicon quantum photonic chips have great potential for large-scale c-EDN, thanks to their capacities on generating and manipulating plenty of entanglement resources

A photon counting reconstructive spectrometer combining metasurfaces and superconducting nanowire single-photon detectors

Faint light spectroscopy has many important applications such as fluorescence spectroscopy, lidar and astronomical observations. However, long measurement time limit its application on real-time measurement. In this work, a photon counting reconstructive spectrometer combining metasurfaces and superconducting nanowire single photon detectors (SNSPDs) was proposed. A prototype device was fabricated on a silicon on isolator (SOI) substrate, and its performance was characterized. Experiment results show that this device support spectral reconstruction of mono-color lights with a resolution of 2 nm in the wavelength region of 1500 nm ~ 1600 nm. The detection efficiency of this device is 1.4% ~ 3.2% in this wavelength region. The measurement time required by this photon counting reconstructive spectrometer was also investigated experimentally, showing its potential to be applied in the scenarios requiring real-time measurement