Liver Damage Associated with Polygonum multiflorum

Objective. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Methods. An extensive search of 6 medical databases was performed up to June 2014. Case reports and case series involving liver damage associated with HSW were included. Results. This review covers a total of 450 cases in 76 articles. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. Symptoms of liver damage occur mostly a month or so after taking the medicine, mainly including jaundice, fatigue, anorexia, and yellow or tawny urine. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. Conclusion. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. People should be alert to liver damage when taking HSW preparations

The scar that takes time to heal: A systematic review of COVID-19-related stigma targets, antecedents, and outcomes

COVID-19, as a crucial public health crisis, has affected our lives in nearly every aspect. Besides its major health threats, COVID-19 brings severe secondary impacts, one of which is the rise of social stigma. Although numerous studies have examined the antecedents and outcomes of COVID-19-related stigma, we still lack a systematic understanding of who is being stigmatized during the COVID-19 pandemic, what exacerbates COVID-19-related stigma, and what impacts COVID-19-related stigma has on victims. Therefore, this review aims to provide a systematic overview of COVID-19-related stigma. With 96 papers conducted with 134,142 individuals in more than 150 countries and territories spanning five continents, we identify three targets that have received the most research: Chinese/Asian people, (suspected) patients and survivors, and healthcare workers. Furthermore, we find that for each stigma target, characteristics of the stigmatized, stigmatizer, and context contribute to COVID-19-related stigma and that this stigma negatively influences victims’ health and non-health outcomes. We call for future research to provide a more integrative, balanced, and rigorous picture of COVID-19-related stigma via conducting research on neglected topics and stigma interventions and using a longitudinal design. In practice, we urge governments and institutions to pay close attention to stigma issues and to promote safe and inclusive societies

The cryosphere change will intensify the summer drought in Qilian Mountains, northeastern of the Tibetan plateau

Study region: This study focuses on the upper reaches of Shule river (URSLH) and Heihe river (URHH) basins and Taolai river (URTLH) basin in Qilian Mountains. Study focus: The impact of the cryosphere changes on runoff components in basins with different cryosphere ratios. New hydrological insights for the region: Total runoff (TR) increased in URSLH and URHH and decreased in URTLH, snowmelt runoff (SR) decreased in each basin, glacier runoff (GR) increased in URSLH and URTLH but decreased in URHH during 1980–2015. In the future, GR will increase under SSP585 and slightly decrease under SSP126 in 2040–2060 in URSLH and decrease in URHH and URSLH. The peak time of SR will advance by a month in each basin. In the future, GR (The ratio of the coefficient of variation (cv) of TR to cv of non-glacial runoff) will decrease, indicating hydrological regulation of glaciers will be weakened in these basins. SR and Rs (The ratio of summer runoff to spring runoff) will show downward trends, the processes of TR increase will be smoother. Rr (The ratio of maximum to minimum monthly runoff) will show downward trends under SSPs. TR will become smoother in each basin. Furthermore, the change of each runoff components will make TR tends to be smoother in the future and reduce TR especially in summer

A 100 Year Sedimentary Record of Heavy Metal Pollution In a Shallow Eutrophic Lake, Lake Chaohu, China

This study has worked on the evaluation of the temporal and spatial evolution of heavy metal contamination in sediment taken from a shallow eutrophic lake, Lake Chaohu, China, over the last 100 years, and thereby used (137)Cs and (210)Pb dating, a PIRLA procedure, statistical analysis, geochemical normalization and a enrichment factor calculation (EF). Concentrations of 5174, 29 325, 10.7, 36.4, 20.4, 386.0, 21.1 and 38.4 mg kg(-1) for Ti, Fe, Co, Cr, Cu, Mn, Pb and Zn, respectively, are proposed as natural background values for the Lake Chaohu based on a PIRLA procedure. The contamination history from the last 100 years can be divided into two periods. Before the 1960s, heavy metal contamination did not occur and there was no spatial difference for heavy metal distribution. Since the 1960s, heavy metal enrichment and contamination has occurred, and the west half of the lake region showed a higher degree of contamination than the east half to various intensified anthropogenic activities. In the east half of the lake region, the anthropogenic source of heavy metals mainly originated from agricultural intensification, whereas in the west half of the lake it originated from city runoff and industry as well as agriculture. In all anthropogenic heavy metals, Co is only from industry