gg-wave Pairing in BiS2_2 Superconductors

Recent angle resolved photoemission spectroscopy(ARPES) experiments have suggested that BiS$_2$ based superconductors are at very low electron doping. Using random phase approximation(RPA) and functional renormalization group(FRG) methods, we find that $g$-wave pairing symmetry belonging to A$_{2g}$ irreducible representation is dominant at electron doping $x<0.25$. The pairing symmetry is determined by inter-pocket nesting and orbital characters on the Fermi surfaces and is robust in a two-orbital model including both Hund's coupling $J$, and Hubbard-like Coulomb interactions $U$ and $U'$ with relatively small $J$ ($J\leq0.2U$). With the increasing electron doping, the g-wave state competes with both the s-wave $A_{1g}$ and d-wave $B_{2g}$ states and no pairing symmetry emerges dominantly.Comment: published version, EPL(editor's choice

MPMQA: Multimodal Question Answering on Product Manuals

Visual contents, such as illustrations and images, play a big role in product manual understanding. Existing Product Manual Question Answering (PMQA) datasets tend to ignore visual contents and only retain textual parts. In this work, to emphasize the importance of multimodal contents, we propose a Multimodal Product Manual Question Answering (MPMQA) task. For each question, MPMQA requires the model not only to process multimodal contents but also to provide multimodal answers. To support MPMQA, a large-scale dataset PM209 is constructed with human annotations, which contains 209 product manuals from 27 well-known consumer electronic brands. Human annotations include 6 types of semantic regions for manual contents and 22,021 pairs of question and answer. Especially, each answer consists of a textual sentence and related visual regions from manuals. Taking into account the length of product manuals and the fact that a question is always related to a small number of pages, MPMQA can be naturally split into two subtasks: retrieving most related pages and then generating multimodal answers. We further propose a unified model that can perform these two subtasks all together and achieve comparable performance with multiple task-specific models. The PM209 dataset is available at https://github.com/AIM3-RUC/MPMQA

Up-regulation of p21 and TNF-α is mediated in lycorine-induced death of HL-60 cells

<p>Abstract</p> <p>Background</p> <p>Leukemia is one of the most life-threatening cancers today, and acute promyelogenous leukemia (APL) is a common type of leukemia. Many natural compounds have already been found to exhibit significant anti-tumor effects. Lycorine, a natural alkaloid extracted from Amaryllidaceae, exhibited anti-leukemia effects in vitro and in vivo. The survival rate of HL-60 cells exposed to lycorine was decreased, cell growth was slowed down, and cell regeneration potential was inhibited. HL-60 cells exhibited typical apoptotic characteristic. Lycorine can suppress leukemia growth and reduce cell survival and inducing apoptosis of tumor cells. The purpose of this work is to elucidate the mechanism by which lycorine induces APL cells.</p> <p>Results</p> <p>When HL-60 cells were treated with different concentration of lycorine, the expression of p21 and TNF-α was up-regulated in a concentration-dependent manner as shown by real-time quantitative reverse transcriptase-polymerase chain reaction and Western blotting. Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IκB phosphorylation and blocked NF-κB nuclear import. Cytochrome c was released from mitochondria as observed with confocal laser microscopy.</p> <p>Conclusions</p> <p>The TNF-α signal transduction pathway and p21-mediated cell-cycle inhibition were involved in the apoptosis of HL-60 cells induced by lycorine. These results contribute to the development of new lycorine-based anti-leukemia drugs.</p