China-ASEAN Relations: Perspectives, Prospects, and Implications for U.S. Interests

The author traces the evolution of China-ASEAN relations since the early 1990s and examines some of the key factors that have contributed to the positive developments in bilateral ties. He describes and analyzes how China and ASEAN have managed the territorial disputes through negotiation and compromises; looks at the expanding economic ties between China and ASEAN member states and examines the politico-strategic, as well as economic rationales for establishing a free trade area; and evaluates the emerging yet still limited defense and security ties between the two. He also assesses the implications of the growing China-ASEAN ties for U.S. interests in the region.https://press.armywarcollege.edu/monographs/1707/thumbnail.jp

Determination of Dark Matter Halo Mass from Dynamics of Satellite Galaxies

We show that the mass of a dark matter halo can be inferred from the dynamical status of its satellite galaxies. Using 9 dark-matter simulations of halos like the Milky Way (MW), we find that the present-day substructures in each halo follow a characteristic distribution in the phase space of orbital binding energy and angular momentum, and that this distribution is similar from halo to halo but has an intrinsic dependence on the halo formation history. We construct this distribution directly from the simulations for a specific halo and extend the result to halos of similar formation history but different masses by scaling. The mass of an observed halo can then be estimated by maximizing the likelihood in comparing the measured kinematic parameters of its satellite galaxies with these distributions. We test the validity and accuracy of this method with mock samples taken from the simulations. Using the positions, radial velocities, and proper motions of 9 tracers and assuming observational uncertainties comparable to those of MW satellite galaxies, we find that the halo mass can be recovered to within $\sim$40%. The accuracy can be improved to within $\sim$25% if 30 tracers are used. However, the dependence of the phase-space distribution on the halo formation history sets a minimum uncertainty of $\sim$20% that cannot be reduced by using more tracers. We believe that this minimum uncertainty also applies to any mass determination for a halo when the phase space information of other kinematic tracers is used.Comment: Accepted for publication in ApJ, 18 pages, 13 figure

DACH1 suppresses breast cancer as a negative regulator of CD44.

Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack of extensive understanding. Herein, we utilized immunohistochemistry (IHC) staining and public microarray data analysis showing that DACH1 was higher in normal breast, low-grade and luminal-type cancer in comparison with breast carcinoma, high-grade and basal-like tumors respectively. Additionally, both correlation analysis of public databases of human breast carcinoma and IHC analysis of mice xenograft tumors demonstrated that DACH1 inversely related to cancer stem cells (CSCs) markers, epithelial-mesenchymal transition (EMT) inducers and basal-enriched molecules, while cluster of differentiation 44 (CD44) behaved in an opposite manner. Furthermore, mice transplanted tumor model indicated that breast cancer cells Met-1 with up-regulation of DACH1 were endowed with remarkably reduced potential of tumorigenesis. Importantly, meta-analysis of 19 Gene Expression Omnibus (GEO) databases of breast cancer implicated that patients with higher DACH1 expression had prolonged time to death, recurrence and metastasis, while CD44 was a promising biomarker predicting worse overall survival (OS) and metastasis-free survival (MFS). Collectively, our study indicated that CD44 might be a novel target of DACH1 in breast carcinoma

A feedback-driven bubble G24.136+00.436: a possible site of triggered star formation

We present a multi-wavelength study of the IR bubble G24.136+00.436. The J=1-0 observations of $^{12}$CO, $^{13}$CO and C$^{18}$O were carried out with the Purple Mountain Observatory 13.7 m telescope. Molecular gas with a velocity of 94.8 km s$^{-1}$ is found prominently in the southeast of the bubble, shaping as a shell with a total mass of $\sim2\times10^{4}$ $M_{\odot}$. It is likely assembled during the expansion of the bubble. The expanding shell consists of six dense cores. Their dense (a few of $10^{3}$ cm$^{-3}$) and massive (a few of $10^{3}$ $M_{\odot}$) characteristics coupled with the broad linewidths ($>$ 2.5 km s$^{-1}$) suggest they are promising sites of forming high-mass stars or clusters. This could be further consolidated by the detection of compact HII regions in Cores A and E. We tentatively identified and classified 63 candidate YSOs based on the \emph{Spitzer} and UKIDSS data. They are found to be dominantly distributed in regions with strong emission of molecular gas, indicative of active star formation especially in the shell. The HII region inside the bubble is mainly ionized by a $\sim$O8V star(s), of the dynamical age $\sim$1.6 Myr. The enhanced number of candidate YSOs and secondary star formation in the shell as well as time scales involved, indicate a possible scenario of triggering star formation, signified by the "collect and collapse" process.Comment: 13 pages, 10 figures, 4 tables, accepted by Ap