The Expressive Power of Graph Neural Networks: A Survey

Graph neural networks (GNNs) are effective machine learning models for many graph-related applications. Despite their empirical success, many research efforts focus on the theoretical limitations of GNNs, i.e., the GNNs expressive power. Early works in this domain mainly focus on studying the graph isomorphism recognition ability of GNNs, and recent works try to leverage the properties such as subgraph counting and connectivity learning to characterize the expressive power of GNNs, which are more practical and closer to real-world. However, no survey papers and open-source repositories comprehensively summarize and discuss models in this important direction. To fill the gap, we conduct a first survey for models for enhancing expressive power under different forms of definition. Concretely, the models are reviewed based on three categories, i.e., Graph feature enhancement, Graph topology enhancement, and GNNs architecture enhancement

Treatment of multisegmental vertebral compression, burst fractures, and sandwich vertebra with severe osteoporosis using the PKP technique: a case report and literature review

This study aimed to present a special case of treatment of a patient with multisegmental vertebral compression fracture, burst fracture, and sandwich vertebra and to review the literature on this condition. An 85 year-old female presented with severe low back pain but no radiating pain in the lower extremities. The patient was diagnosed with T12 and L5 vertebral compression fractures, fresh vertebral burst fractures in L2 and L3, and osteoporosis. The focus was on formulating a surgical treatment strategy. At the 12 month follow-up, no neurological deficits were observed, and the chosen surgical treatment approach yielded favorable clinical outcomes. A comprehensive literature review indicates that percutaneous kyphoplasty (PKP) can effectively alleviate pain and ensure safety in managing osteoporotic vertebral burst fractures. While complications remain a theoretical risk, they can be mitigated through meticulous assessment, careful surgical procedures, and appropriate preventive measures. PKP is an effective and safe treatment modality for osteoporotic vertebral burst fractures. Conservative management of sandwich vertebrae can yield positive clinical outcomes, but regular anti-osteoporosis treatment is necessary

Cyclic Injection to Enhance Hydraulic Fracturing Efficiency: Insights from Laboratory Experiments

In hydraulic fracturing applications, there is substantial interest to reduce the formation breakdown pressure. Previous research results show that the cyclic injection method can be used to reduce that pressure. In this study, we conducted laboratory hydraulic fracturing experiments to apply cyclic injection to reduce the breakdown pressures of very tight and strong sandstones. Experimental results show that using cyclic injection the average breakdown pressure was reduced by 18.9% in very tight sandstones and by 7.18% in normal sandstones. This indicates that the effect of cyclic injection is more significant for stronger and tighter rocks. The experiments also reveal that the rock tensile strength plays a more important role in the formation breakdown pressure with a rock strength factor of 2.85. This suggests that the breakdown pressure is higher than expected. In addition, we empirically related the breakdown pressure reduction and the injection pressure amplitude to the number of injection cycles. The curve fitting results imply that the effect of cyclic injection is more important if the number of cycles or the injection pressure amplitude is increased. Based on the results of this research, the in-situ formation breakdown pressure can be reduced by applying the cyclic injection method, and the breakdown pressure reduction is more significant as the number of cycles increases

The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths

Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Samples were studied by light microscopy using routine hematoxylin and eosin histochemical staining, and immunohistochemistry to detect CD20-positive B-lymphocytes and CD3-positive T-lymphocytes. Sirius Red histochemical staining was used to determine the type of collagen in keloid tissue and normal skin samples. The migratory properties of fibroblasts within the keloid dermis at different depths was compared, using an in vitro migration assay. The findings of this study showed that although the papillary and reticular dermis could be clearly distinguished in normal skin, three tissue layers were identified in the keloid dermis. The superficial dermis of keloid was characterized by active fibroblasts and lymphocytes; the middle dermis contained dense extracellular matrix (ECM) with large numbers fibroblasts, and the deep dermis was poorly cellular and characterized by hyalinized collagen bundles. In the keloid samples, from the superficial to the deep dermis, type I collagen increased and type III collagen decreased, and fibroblasts from the superficial dermis of the keloid were found to migrate more rapidly. In conclusion, the findings of this study showed that different depths within the keloid dermis displayed different biological features. The superficial dermis may initiate keloid formation, in which layer intralesional injection of pharmaceuticals and other treatments should be performed for keloid

Influences of sandstone superimposed structure and architecture on waterflooding mechanisms: A case study of Kumkol Oilfield in South Turgay Basin, Kazakhstan

Taking the Kumkol oilfield of high water cut in the South Turgay Basin, Kazakstan as an example, this article built the architecture models of meandering river sandstones, braided river sandstones and delta sandstones, and analyzed the influence of the superimposed structure characteristics between different types of sandstones and internal architecture features on warterflooding mechanisms and effects. The meandering river sandstones are mainly characterized by lateral accretion shale beddings inside, with simple overlay-relationship in sand bodies. In meandering river sandstones, injected water almost sweeps through the bottom of sand bodies and the bottom part of the sandstones is previously waterflooded, and the thickness ratio of strong and moderate waterflooded zone is about 51.8%. Braided river sandstones are characterized by nearly horizontal interlayers inside, with low heterogeneity and uniform waterflooding sweep vertically, and the thickness ratio of strong and moderate waterflooded zone is as high as 81.7%. The superimposed structure and architecture of delta sandstone is relatively complicated; different types of sandstones overlay each other frequently and shale interbeds are developed in sandstones. The injected water is obstructed not only by impermeable or low-permeable layers between sand bodies but also by shale interbeds in sandstones, with low sweep range of injected water, and the thickness ratio of strong and moderate waterflooded zone is only 32.6%. The braided river sandstone has low rising velocity of water cut and high no-water recovery degree, and its waterflooding development effect is the best. The waterflood sweep of delta sandstones is poor, with fast rising velocity of water cut and low no-water recovery degree, and its waterflooding development effect is the worst. The waterflooding development effect of meandering river sandstones is moderate among these three types of sandstones. Key words: South Turgay Basin, sandstone type, meandering river, braided river, delta, warterflooding degree, warterflooding characteristics, remaining oi

Technique policy for concurrent development of natural and artificial water flooding of strong edge water reservoir: A case study of central layer Yu-III of Akshabulak oilfield

The central layer Yu-III in Akshabulak oilfield is a sandstone reservoir with strong edge water, whose major development characteristics are high oil recovery rate and heterogeneous water invasion. Aiming at this problem, the development policy chart of concurrent displacement of natural water and injected water is established on the basis of material balance principle. Injection-production ratio and oil recovery rate are the main controlling factors for the concurrent displacement of natural water and injected water. Each injection-production ratio corresponds with only one rational oil recovery rate, and the rational oil recovery rate increases with the injection-production ratio. When the actual injection-production ratio of the central Yu-III reservoir is 0.9, the rational oil recovery rate should be 4%

Effects of oil viscosity on waterflooding: A case study of high water-cut sandstone oilfield in Kazakhstan

After a sandstone oilfield enters the high water-cut period, the viscosity of crude oil has an important influence on remaining oil distribution and waterflooding characteristics under the same factors of, e.g., reservoir quality and development methods. Based on a comprehensive interpretation of the waterflooded layers in new oil wells, physical simulation experiments, and reservoir numerical simulations, we analyzed the waterflooding laws of a high water-cut sandstone reservoir with different oil viscosities in Kazakhstan under the same oil production speed, and we clarified the remaining oil potential of reservoirs with different viscosities and proposed corresponding development measures. The results show that low-viscosity oil reservoirs (1 mPa s) have uniform waterflooding, thick streamlines, small waterflooding areas, and low overall waterflooding degrees because of their homogeneous oil–water viscosities. However, within waterflooded areas, the reservoirs have high oil displacement efficiencies and high waterflooding degrees, and the remaining oil is mainly concentrated in the unwaterflooded areas; therefore, the initial production and water cut in new oil wells vary significantly. High-viscosity oil reservoirs (200 mPa s) have severe waterflooding fingering, large waterflooding areas, and high overall waterflooded degrees because of their high oil–water mobility ratios. However, within waterflooded areas, the reservoirs have low oil displacement efficiencies and low waterflooding degrees, and the remaining oil is mainly concentrated in both the waterflooded areas and the unwaterflooded areas; therefore, the differences in the initial production and water cut of new oil wells are small. Moderate-viscosity oil reservoirs (20 mPa s) are characterized by remaining oil distributions that are somewhere in between those of the former two reservoirs. Therefore, in the high water-cut period, as the viscosity of crude oil increases, the efficiency of waterflooding gradually deteriorates and the remaining oil potential increases. In the later development, it is suggested to implement the local well pattern thickening in the remaining oil enrichment area for reservoirs with low viscosity, whereas a gradual overall well pattern thickening strategy is recommended for whole reservoirs with moderate and high viscosity. The findings of this study can aid better understanding of waterflooding law and the remaining oil potential of reservoirs with different viscosities and proposed corresponding development measures. The research results have important guidance and reference significance for the secondary development of high water-cut sandstone oilfields

Technique policy for concurrent development of natural and artificial water flooding of strong edge water reservoir: A case study of central layer Yu-III of Akshabulak oilfield

The central layer Yu-III in Akshabulak oilfield is a sandstone reservoir with strong edge water, whose major development characteristics are high oil recovery rate and heterogeneous water invasion. Aiming at this problem, the development policy chart of concurrent displacement of natural water and injected water is established on the basis of material balance principle. Injection-production ratio and oil recovery rate are the main controlling factors for the concurrent displacement of natural water and injected water. Each injection-production ratio corresponds with only one rational oil recovery rate, and the rational oil recovery rate increases with the injection-production ratio. When the actual injection-production ratio of the central Yu-III reservoir is 0.9, the rational oil recovery rate should be 4%

High-Resolution Bioassay Profiling with Complemented Sensitivity and Resolution for Pancreatic Lipase Inhibitor Screening

How to rapidly and accurately screen bioactive components from complex natural products remains a major challenge. In this study, a screening platform for pancreatic lipase (PL) inhibitors was established by combining magnetic beads-based ligand fishing and high-resolution bioassay profiling. This platform was well validated using a mixture of standard compounds, i.e., (-)- epigallocatechin gallate (EGCG), luteolin and schisandrin. The dose–effect relationship of high-resolution bioassay profiling was demonstrated by the standard mixture with different concentrations for each compound. The screening of PL inhibitors from green tea extract at the concentrations of 0.2, 0.5 and 1.0 mg/mL by independent high-resolution bioassay profiling was performed. After sample pre-treatment by ligand fishing, green tea extract at the concentration of 0.2 mg/mL was specifically enriched and simplified, and consequently screened through the high-resolution bioassay profiling. As a result, three PL inhibitors, i.e., EGCG, (-)-Gallocatechin gallate (GCG) and (-)-Epicatechin gallate (ECG), were rapidly identified from the complex matrix. The established platform proved to be capable of enriching affinity binders and eliminating nonbinders in sample pre-treatment by ligand fishing, which overcame the technical challenges of high-resolution bioassay profiling in the aspects of sensitivity and resolution. Meanwhile, the high-resolution bioassay profiling possesses the ability of direct bioactive assessment, parallel structural analysis and identification after separation. The established platform allowed more accurate and rapid screening of PL inhibitors, which greatly facilitated natural product-based drug screening