An Empirical Study on Verbal Violence Experiences among Bank Consulting

The development of smart devices and the products of ICT are becoming a medium for verbal abuse, causing serious problems in bank counseling. Research on verbal abuse in the bank counseling process started at call centers, and as the damage caused by verbal abuse is known, a lot of research were rapidly conducted. These include the understanding of verbal violence and the closest group in which verbal violence can occur over a long period of time and the horizontal and vertical forms of verbal violence. There are also multilateral studies to identify the causes of verbal violence and to reduce verbal violence. The scope of verbal violence also varies with definition, phenomenon, type, cause, effect, and factor. In the early days of the study of verbal violence, definitions and types were central.  This study focuses on analyzing the relationship of the impact on professional self-concept through psychological exhaustion of verbal violence experiences during bank counseling. Verbal violence is categorized as violence against people who are not related to them and those who are related to them. Verbal violence against irrelevant people is an impromptu violence situation between the perpetrator and the victim during various counseling processes.  It refers to violence committed against others during counseling through cyberspace and various media. Personal violence in the counseling process tends to be neglected because the substance is not clear, but the damage is continuing and increasing. Although various psychological studies have been conducted on real violence, there are no studies related to psychological exhaustion and professional self-concept. The factors that determine the verbal violence experience are the violence experience, the violence victim experience, and the violent attitude. The collected data were analyzed by Smart PLS 2.0 using structural equations. The summary of the study is as follows. First, the experience of violence had a significant impact on psychological exhaustion. Second, the experience of violence damage had a significant impact on psychological exhaustion. Third, violent personality had a significant effect on psychological exhaustion. Fourth, psychological exhaustion had a significant impact on professional self-concepts. To solve the problem of overcoming professional self-concepts, differentiated efforts in the experience of violence, violence victimization, and violent attitude are needed in consideration of verbal violence experiences. Related organizations seeking to address verbal violence need to study various opinions on the causes of verbal violence behavior

Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal neuralgia

Trigeminal neuralgia (TN) is a common, debilitating neuropathic face pain syndrome often resistant to therapy. The familial clustering of TN cases suggests that genetic factors play a role in disease pathogenesis. However, no unbiased, large-scale genomic study of TN has been performed to date. Analysis of 290 whole exome-sequenced TN probands, including 20 multiplex kindreds and 70 parent-offspring trios, revealed enrichment of rare, damaging variants in GABA receptor-binding genes in cases. Mice engineered with a TN-associate

CD137 signaling regulates acute colitis via RALDH2-expressing CD11b−CD103+ DCs

CD137, a potent costimulatory receptor for CD

Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia

Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated risk of arteriosclerotic coronary heart disease. Heritability of HDL-C levels is high. In this research discovery study, we used whole-exome sequencing to identify damaging gene variants that may play significant roles in determining HDL-C levels. We studied 204 individuals with a mean HDL-C level of 27.8 ± 6.4 mg/dl (range: 4-36 mg/dl). Data were analyzed by statistical gene burden testing and by filtering against candidate gene lists. We found 120 occurrences of probably damaging variants (116 heterozygous; four homozygous) among 45 of 104 recognized HDL candidate genes. Those with the highest prevalence of damaging variants were ABCA1 (n = 20), STAB1 (n = 9), OSBPL1A (n = 8), CPS1 (n = 8), CD36 (n = 7), LRP1 (n = 6), ABCA8 (n = 6), GOT2 (n = 5), AMPD3 (n = 5), WWOX (n = 4), and IRS1 (n = 4). Binomial analysis for damaging missense or loss-of-function variants identified the ABCA1 and LDLR genes at genome-wide significance. In conclusion, whole-exome sequencing of individuals with low HDL-C showed the burden of damaging rare variants in the ABCA1 and LDLR genes is particularly high and revealed numerous occurrences in HDL candidate genes, including many genes identified in genome-wide association study reports. Many of these genes are involved in cancer biology, which accords with epidemiologic findings of the association of HDL deficiency with increased risk of cancer, thus presenting a new area of interest in HDL genomics

International Stroke Genetics Consortium recommendations for studies of genetics of stroke outcome and recovery

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium

Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics

Enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles (cerebral ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly recognized among patients with autism spectrum disorders (ASD)