Development environment construction of medical imaging software 3d slicer

3D Slicer is an open source software platform for medical image informatics, image processing and 3D visualization. Due to different medical functional requirements, a 3D slicer tailored to the doctor's needs is a great choice for people. However, the development of open source software has some difficulties in environment construction and other aspects. In this paper, after repeated attempts, literature review and research, GitHub download, CMAKE compilation and VS generation of the appropriate version were found. It can quickly build a 3D Slicer programming environment, which is of great significance for the subsequent modification and development of 3D Slicer

Efficiency optimization of an interleaved buck-boost converter with wide operation range

Improving the efficiency of DC/DC converters has been a widely researched topic. This dissertation focuses on the investigation of bidirectional interleaved DC/DC converters, which exhibit higher efficiency compared to traditional single-phase DC/DC converters. However, these bidirectional converters often suffer from lower efficiency under light load conditions. To address this issue, two advanced control methods, namely Discontinuous Conduction Mode Control (DCM) and Variable Frequency Control (VF), are adopted as alternatives to Continuous Conduction Mode (CCM) to enhance the converter's efficiency. To compare the efficiency of these three methods, power loss calculations are performed, and power loss decomposition is carried out to derive four types of loss analysis models. The power loss calculations are conducted under six different light load conditions, allowing for a comprehensive comparison of efficiency in each case to determine the optimal control method. The accuracy of the conclusions is validated by demonstrating a high level of consistency between the model calculations and Simulink simulation results. By conducting this study, the most effective control method can be identified to enhance the efficiency of bidirectional interleaved parallel DC/DC converters under various load conditions.Master of Science (Power Engineering

Get Us PPE: A Self-Organizing Platform Ecosystem for Supply Chain Optimization during COVID-19

The COVID-19 pandemic caused a global health emergency that triggered an acute shortage of Personal Protective Equipment (PPE), putting essential healthcare workers at risk. Starting March 2020, given the skyrocketing prices of PPE in the open market, healthcare institutions were confronted with the dire need to reshape their PPE procurement strategy. One avenue that financially constrained healthcare institutions pursued were donation platforms that offered access to donated PPE by individuals and organizations. We document a real-life case study of one of the most prominent donor platforms that emerged during this period: Get Us PPE. From 20 March 2020 to 2 July 2021, Get Us PPE received 23,001 total individual requests for PPE from every US state and some US territories. In response to these 23,001 requests, Get Us PPE delivered 17,540,571 units of PPE. The number of PPE units delivered was still less than 25% of the total units of PPE requested, indicating the enormity of the PPE shortage. Using this case study, we identify key supply chain issues that manifest during emergencies and highlight the formation of a platform ecosystem to resolve these issues. We also observed a robust supply chain network design that addresses key supply chain sustainability metrics such as minimizing material waste and transportation miles, while balancing other stakeholder factors such as donor and recipient characteristics as well as shipment complexity. We argue that the roadmap followed by Get Us PPE could serve as a template for organizations that emerge in the context of future humanitarian crises

Get Us PPE: A Self-Organizing Platform Ecosystem for Supply Chain Optimization during COVID-19

The COVID-19 pandemic caused a global health emergency that triggered an acute shortage of Personal Protective Equipment (PPE), putting essential healthcare workers at risk. Starting March 2020, given the skyrocketing prices of PPE in the open market, healthcare institutions were confronted with the dire need to reshape their PPE procurement strategy. One avenue that financially constrained healthcare institutions pursued were donation platforms that offered access to donated PPE by individuals and organizations. We document a real-life case study of one of the most prominent donor platforms that emerged during this period: Get Us PPE. From 20 March 2020 to 2 July 2021, Get Us PPE received 23,001 total individual requests for PPE from every US state and some US territories. In response to these 23,001 requests, Get Us PPE delivered 17,540,571 units of PPE. The number of PPE units delivered was still less than 25% of the total units of PPE requested, indicating the enormity of the PPE shortage. Using this case study, we identify key supply chain issues that manifest during emergencies and highlight the formation of a platform ecosystem to resolve these issues. We also observed a robust supply chain network design that addresses key supply chain sustainability metrics such as minimizing material waste and transportation miles, while balancing other stakeholder factors such as donor and recipient characteristics as well as shipment complexity. We argue that the roadmap followed by Get Us PPE could serve as a template for organizations that emerge in the context of future humanitarian crises

Exploring the Pathological Role of Collagen in Paravertebral Muscle in the Progression of Idiopathic Scoliosis

Background. Paravertebral muscle (PVM) is considered as a contributing factor of idiopathic scoliosis (IS); collagen is crucial for maintaining the mechanical properties of PVM, but only a few researches have described this field. In this study, we observed the muscle stiffness of PVM and the curvature of the spine by adjusting the content of collagen in PVM of rats and explored the role of collagen in the progression of IS. Methods. 32 female Sprague Dawley rats were randomly divided into four groups: neutralizing antibody (NA) group (group 1), normal control group (group 2), IS group (group 3), and IS with NA group (group 4). TGF-β1 NA was injected into PVM in group 1 and group 4, while Normal saline in group 2 and group 3. The Cobb angle and muscle stiffness were measured before and after injection; the rats were sacrificed at one week after injection, and performed histological, Western Blot, and qRT-PCR examinations. Results. X-rays showed that scoliosis occurred in group 1 and relieved in group 4. The stiffness of PVM was decreased significantly on the convex side in group 1, while on the concave side in group 4. The expression of TGF-β1 and COL1 on the concave side in IS rats (group 3) was significantly increased than that in normal rats (group 2), the concentration of COL1 and COL3 in group 3 was significantly higher than that in group 2, and the addition of TGF-β1 NA significantly downregulated COL1 and COL3 in group 1 and group 4. The concentration of COL1 in convex PVM was negatively related to Cobb angle in group 1 and group 2, and in concave PVM was positively related to Cobb angle in group 3 and group 4. However, no significant correlation was found between COL3 and Cobb angle in group 3 and group 4. Conclusions. Asymmetric biomechanical characteristics of PVM was an important etiological factor of IS, which was directly correlated with collagen, it could be adjusted by local intramuscular injecting of TGF-β1 NA, and finally had an effect on the shape of the spine

Metal–Organic Frameworks for Electrocatalytic Sensing of Hydrogen Peroxide

The electrochemical detection of hydrogen peroxide (H2O2) has become more and more important in industrial production, daily life, biological process, green energy chemistry, and other fields (especially for the detection of low concentration of H2O2). Metal organic frameworks (MOFs) are promising candidates to replace the established H2O2 sensors based on precious metals or enzymes. This review summarizes recent advances in MOF-based H2O2 electrochemical sensors, including conductive MOFs, MOFs with chemical modifications, MOFs-composites, and MOF derivatives. Finally, the challenges and prospects for the optimization and design of H2O2 electrochemical sensors with ultra-low detection limit and long-life are presented

Comparison of Antioxidant Capacity and Muscle Amino Acid and Fatty Acid Composition of Nervous and Calm Hu Sheep

This study determined the effect of temperament on antioxidant capacity and the relationship between antioxidant capacity and the contents of amino acids (AA) and fatty acids (FA) in muscle of Hu sheep. Organ and muscle samples of five calm and five nervous Hu sheep were collected to determine the antioxidant capacity and the contents of AA and FA in muscle tissue. The concentrations of malondialdehyde (MDA) and superoxide excretion enzyme (SOD) in muscle and intestinal tissue of calm Hu sheep were lower than those of nervous Hu sheep (p p = 0.050). The content of AA of calm Hu sheep was higher than that of nervous Hu sheep, especially the content of reductive amino acids, which was significantly higher than that of nervous Hu sheep (p = 0.029). Fatty acid content of nervous Hu sheep was higher than that of calm type, and saturated fatty acid content was significantly higher than that of calm type (p = 0.001). The SOD content in muscle tissue was positively correlated with the contents of aspartic acid (Asp), alanine (Ala) and lysine (Lys). Catalase (CAT) activity was positively correlated with Ala content. There was a significant positive correlation between total antioxidants (T-AOC) and glutamate (Glu) (p p p < 0.05). Our conclusion is that the antioxidant capacity of calm Hu sheep is superior to that of nervous Hu sheep, which may be due to the higher AA (especially reductive amino acids (Arg, Lys, Ala and Glu)) content in the muscle and the lower FA (especially SFA) content, which improve the antioxidant capacity of the organism and allow for further exploration of the mechanisms by which animal temperament affects antioxidant performance