2,5-Bis[(3-chloro­benz­yl)sulfan­yl]-1,3,4-thia­diazole

The complete mol­ecule of the title compound, C16H12Cl2N2S3, is generated by crystallographic twofold symmetry, with the S atom of the thiadiazole ring lying on the rotation axis. The dihedral angle between the mean planes of the 1,3,4-thia­diazole and benzene rings is 87.19 (7)°. In the crystal, mol­ecules are linked by C—H⋯N inter­actions and short S⋯S contacts [3.3389 (9) Å] occur

Gravitational Lensing Effects of Fermion-Fermion Stars: I. Strong Field Case

We investigate a two-component model for gravitational lenses, i.e., the fermion-fermion star as a dark matter self-gravitating system made from two kinds of fermions with different masses. We calculate the deflection angles varying from arcseconds to even degrees. There is one Einstein ring. In particular, we find three radial critical curves for radial magnifications and four or five images of a point source. These are different from the case of the one-component model such as the fermion stars and boson stars. This is due to the fermion-fermion star being a two-component concentric sphere. Our results suggest that any possible observations of the number of images more than 3 could imply a polytropic distribution of the mass inside the lens in the universe.Comment: 7 pages, LaTex and PostScript; 4 figures, PostScrip

N′-[(E)-2-Hydroxy­benzyl­idene]-5-methyl­isoxazole-4-carbohydrazide monohydrate

In the structure of the title compound, C12H11N3O3·H2O, the dihedral angle formed by the benzene and isoxazole rings is 2.03 (8)°. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯N hydrogen bond. In the crystal structure, mol­ecules are linked into a three-dimesional network by inter­molecular N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, and by π–π stacking inter­actions involving adjacent benzene and isoxazole rings [centroid–centroid separation = 3.663 (2) Å]

Aerosolised surfactant generated by a novel noninvasive apparatus reduced acute lung injury in rats

Abstract Introduction Exogenous surfactant has been explored as a potential therapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In the present study, a nebuliser driven by oxygen lines found in the hospital was developed to deliver aerosolised porcine pulmonary surfactant (PPS). We hypothesised that aerosolised surfactant inhaled through spontaneous breathing may effectively reduce severe lung injury. Methods Rats were intravenously injected with oleic acid (OA) to induce ALI and 30 minutes later they were divided into five groups: model (injury only), PPS aerosol (PPS-aer), saline aerosol (saline-aer), PPS instillation (PPS-inst), and saline instillation (Saline-Inst). Blood gases, lung histology, and protein and TNF-α concentrations in the bronchoalveolar lavage fluid (BALF) were examined. Results The PPS aerosol particles were less than 2.0 μm in size as determined by a laser aerosol particle counter. Treatment of animals with a PPS aerosol significantly increased the phospholipid content in the BALF, improved lung function, reduced pulmonary oedema, decreased total protein and TNF-α concentrations in BALF, ameliorated lung injury and improved animal survival. These therapeutic effects are similar to those seen in the PPS-inst group. Conclusions This new method of PPS aerosolisation combines the therapeutic effects of a surfactant with partial oxygen inhalation under spontaneous breathing. It is an effective, simple and safe method of administering an exogenous surfactant