A Unified Accurate Solution for Three-dimensional Vibration Analysis of Functionally Graded Plates and Cylindrical Shells with General Boundary Conditions

Three-dimensional (3-D) vibration analysis of thick functionally graded plates and cylindrical shells with arbitrary boundary conditions is presented in this chapter. The effective material properties of functionally graded structures vary continuously in the thickness direction according to the simple power-law distributions in terms of volume fraction of constituents and are estimated by Voigt’s rule of mixture. By using the artificial spring boundary technique, the general boundary conditions can be obtained by setting proper spring stiffness. All displacements of the functionally graded plates and shells are expanded in the form of the linear superposition of standard 3-D cosine series and several supplementary functions, which are introduced to remove potential discontinuity problems with the original displacements along the edge. The Rayleigh-Ritz procedure is used to yield the accurate solutions. The convergence, accuracy and reliability of the current formulation are verified by numerical examples and by comparing the current results with those in published literature. Furthermore, the influence of the geometrical parameters and elastic foundation on the frequencies of rectangular plates and cylindrical shells is investigated

Method for preparing ultra-high drug-loaded nanoparticles by means of sequence precipitation-complex coacervation

The invention discloses a kind of methods that sequence precipitation and complexation coacervation prepares superelevation medicine-carried nano particles, after first the first reactant and the second reactant are mixed in first reactor so that active pharmaceutical ingredient precipitates form medicament nano granule kernel in the first reactor;The reaction product of first reactor flows in second reactor rapidly, is mixed with third reactant, and enclosure material occurs to deposit to the surface of medicament nano granule kernel after complex coacervation reacts, and forms the superelevation medicine-carried nano particles with nucleocapsid

Nanoparticle with super high-drug loading capacity and manufacturing method thereof

A nanoparticle, a manufacturing method, and an apparatus for the manufacturing method. The nanoparticle comprises a nano-nucleus containing an active pharmaceutical ingredient, and an outer shell controlling the release of a pharmaceutical product. The mass of the active pharmaceutical ingredient comprises 30-85% of the mass of the entire nanoparticle. The nanoparticle has a diameter of 50-2,000 nm

Simultaneous measurement of displacement and temperature based on two cascaded balloon-like bent fibre structures

A low-cost optical fibre sensor based on two cascaded balloon-like bent fibre (BBF) structures for simultaneous displacement and temperature measurement is reported. The sensor is fabricated by cascading two balloon-like bent single-mode fibres (SMFs) which with different bending radii, generating two separate interference dips within a limited wavelength range. The wavelength of the two interference dips exhibits different responses to external displacement and temperature variations, hence simultaneous measurement of displacement and temperature is realized. Experimental results show that the proposed optical fibre sensor achieves a displacement sensitivity of −318.8 pm/μm and a temperature sensitivity of 47.4 pm/°C. Taking advantage of its low-cost, ease of fabrication, and experimentally determined high sensitivity, the sensor in this investigation can be potentially applied in both displacement and temperature measurement fields